Yantu gongcheng xuebaoThe accurate evaluation of water-gas transport is important for pollution control in landfill earthen covers. With poor sealing effects, most of the existing model test instruments cannot accurately control the air pressure and simulate the boundary ...
LU Zichen 1, 2, CHEN Rui 1, 2, WANG Hao 1, 2, CHEN Zibin 1, 2, GUO Haowen 3, HUANG Junwen 1, 2
doaj +1 more source
LiDAR Point Cloud Data Combined Structural Analysis Based on Strong Form Meshless Method Using Essential Boundary Condition Capturing. [PDF]
Sensors (Basel), 2023 Seo KW, Yoon YC, Lee SH.
europepmc +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Parametric analysis of an efficient boundary condition to control outlet flow rates in large arterial networks. [PDF]
Sci Rep, 2022 Lo SCY, McCullough JWS, Coveney PV.
europepmc +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Dynamics of the p-Laplacian equations with nonlinear dynamic boundary conditions
Electronic Journal of Differential Equations, 2015 In this article, we study the long-time behavior of the p-Laplacian equation with nonlinear dynamic boundary conditions for both autonomous and non-autonomous cases. For the autonomous case, some asymptotic regularity of solutions is proved.
Xiyou Cheng, Lei Wei
doaj
Effective data sampling strategies and boundary condition constraints of physics-informed neural networks for identifying material properties in solid mechanics. [PDF]
Appl Math Mech, 2023 Wu W +4 more
europepmc +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Boundary optimal control of time-space SIR model with nonlinear Robin boundary condition. [PDF]
Int J Dyn Control, 2022 Essoufi EH, Zafrar A.
europepmc +1 more source