Results 61 to 70 of about 6,259,109 (294)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Simulation of copper–water nanofluid in a microchannel in slip flow regime using the lattice Boltzmann method with heat flux boundary condition

open access: yes, 2015
Laminar forced convection heat transfer of water-Cu nanofluids in a microchannel is studied using the double population Thermal Lattice Boltzmann method (TLBM). The entering flow is at a lower temperature compared to the microchannel walls.
A. D'Orazio, Z. Nikkhah, A. Karimipour
semanticscholar   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Resonant (p,q)-equations with Robin boundary condition

open access: yesElectronic Journal of Differential Equations, 2018
We consider a nonlinear nonhomogeneous Robin problem that has the sum of a p-Laplacian and a q-Laplacian (a (p,q)-equation). The reaction term is a Caratheodory function which is resonant at $\pm\infty$ with respect to any nonprincipal variational ...
Michael E. Filippakis   +1 more
doaj  

3D Casson fluid flow past a porous linearly stretching sheet with convective boundary condition

open access: yes, 2015
In the present problem a magnetohydrodynamic (MHD) three dimensional Casson fluid flow past a porous linearly stretching sheet is investigated, introducing convective boundary condition at the surface where the thermal conductivity of the fluid varies ...
G. Mahanta, S. Shaw
semanticscholar   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Navier-Stokes equation with slip-like boundary condition

open access: yesElectronic Journal of Differential Equations, 2009
The aim of this note is to investigate a time-discretized 2-dimensional Navier-Stokes equation with a slip-like boundary condition, which arises in the melting ice problem. We prove the existence and uniqueness of a weak solution.
Ken'ichi Hashizume   +2 more
doaj  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Boundary value problems with an integral constraint

open access: yesElectronic Journal of Differential Equations, 2015
We show the existence of solutions for a second-order ordinary differential equation coupled with a boundary-value condition and an integral condition.
Elisabetta M. Mangino, Eduardo Pascali
doaj  

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