Results 71 to 80 of about 6,259,109 (294)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Generalized solution of boundary value problem with an inhomogeneous boundary condition

MANAS: Journal of Engineering, 2019
In this problem, we study the solution to boundary value problem for a controlled oscillation process, described by Fredholm integro-differential equation with an inhomogeneous boundary condition.
Elmira Abdyldaeva, Gulbarchyn Taalaibek Kyzy, Bermet Anarkulova   +2 more
doaj  

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Fine-Grained Boundary Conditions in Field-Based Routing

Sensors
In the realm of industrial wireless mesh networks, an efficient routing protocol is highly demanded to play a crucial role in ensuring that packets are efficiently directed along shorter and congestion-free routes toward gateways. Field-based routing has
Jihoon Sung, Yeunwoong Kyung
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Reaction diffusion equations with boundary degeneracy

Electronic Journal of Differential Equations, 2016
In this article, we consider the reaction diffusion equation $$ \frac{\partial u}{\partial t} = \Delta A(u),\quad (x,t)\in \Omega \times (0,T), $$ with the homogeneous boundary condition.
Huashui Zhan
doaj  

Numerical simulation of nanofluid flow with convective boundary condition

, 2015
In this paper, the heat and mass transfer of an electrically conducting incompressible nanofluid over a heated stretching sheet with convective boundary condition is investigated.
K. Das, P. R. Duari, P. K. Kundu
semanticscholar   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Correcting Multivariate Biases in Regional Climate Model Boundaries: How Are Synoptic Systems Impacted Over the Australian Region?

Geophysical Research Letters
Synoptic climatology, which connects atmospheric circulation with regional environmental conditions, is pivotal to understanding climate dynamics. While regional climate models (RCMs) can reproduce key mesoscale precipitation patterns, biases related to ...
Youngil Kim, Jason P. Evans, Ashish Sharma   +2 more
doaj   +1 more source