Results 81 to 90 of about 7,097,559 (319)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Bulk flows in Virasoro minimal models with boundaries

, 2009
The behaviour of boundary conditions under relevant bulk perturbations is studied for the Virasoro minimal models. In particular, we consider the bulk deformation by the least relevant bulk field which interpolates between the mth and (m-1)st unitary ...
Ahn C, Bachas C, Brunner I, Cardy J L Brézin E Zinn-Justin J, Castro-Alvaredo O A, Cherednik I V, Cornelius Schmidt-Colinet, Fredenhagen S, Fredenhagen S, Fredenhagen S, Gaberdiel M R, Gaberdiel M R, Gaberdiel M R, Graham K, Graham K, Kormos M Runkel I Watts G M T, Matthias R Gaberdiel, Sklyanin E K, Stefan Fredenhagen, Zamolodchikov A B, Zamolodchikov A B, Zamolodchikov A B, Zamolodchikov A B, Zamolodchikov A B   +23 more
core   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The Coulomb gauge ghost Dyson-Schwinger equation

, 2010
A numerical study of the ghost Dyson-Schwinger equation in Coulomb gauge is performed and solutions for the ghost propagator found. As input, lattice results for the spatial gluon propagator are used.
Reinhardt, Hugo, Watson, Peter
core   +1 more source

Resonant (p,q)-equations with Robin boundary condition

Electronic Journal of Differential Equations, 2018
We consider a nonlinear nonhomogeneous Robin problem that has the sum of a p-Laplacian and a q-Laplacian (a (p,q)-equation). The reaction term is a Caratheodory function which is resonant at $\pm\infty$ with respect to any nonprincipal variational ...
Michael E. Filippakis, Nikolaos S. Papageorgiou   +1 more
doaj  

Influence of Variable Thermal Conductivity on MHD Boundary Layer Slip Flow of Ethylene-Glycol Based Cu Nanofluids over a Stretching Sheet with Convective Boundary Condition

, 2014
An analysis is carried out to investigate the influence of variable thermal conductivity and partial velocity slip on hydromagnetic two-dimensional boundary layer flow of a nanofluid with Cu nanoparticles over a stretching sheet with convective boundary ...
N. Reddy, T. Poornima, P. Sreenivasulu
semanticscholar   +1 more source

The Nahm Pole Boundary Condition [PDF]

, 2013
The Nahm pole boundary condition for certain gauge theory equations in four and five dimensions is defined by requiring that a solution should have a specified singularity along the boundary.
R. Mazzeo, E. Witten
semanticscholar   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Navier-Stokes equation with slip-like boundary condition

Electronic Journal of Differential Equations, 2009
The aim of this note is to investigate a time-discretized 2-dimensional Navier-Stokes equation with a slip-like boundary condition, which arises in the melting ice problem. We prove the existence and uniqueness of a weak solution.
Ken'ichi Hashizume, Tetsuya Koyama, Mitsuharu Otani   +2 more
doaj  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source