Results 61 to 70 of about 2,653,054 (281)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Fractional-order boundary value problem with Sturm-Liouville boundary conditions

Electronic Journal of Differential Equations, 2015
Using the new conformable fractional derivative, which differs from the Riemann-Liouville and Caputo fractional derivatives, we reformulate the second-order conjugate boundary value problem in this new setting.
Douglas R. Anderson, Richard I. Avery
doaj  

Conformal boundary conditions from cutoff AdS3

Journal of High Energy Physics, 2021
We construct a particular flow in the space of 2D Euclidean QFTs on a torus, which we argue is dual to a class of solutions in 3D Euclidean gravity with conformal boundary conditions.
Evan Coleman, Vasudev Shyam
doaj   +1 more source

Hydrodynamic type integrable equations on a segment and a half-line [PDF]

, 2008
The concept of integrable boundary conditions is applied to hydrodynamic type systems. Examples of such boundary conditions for dispersionless Toda systems are obtained.
Dubrovin B. A., Gibbons J., Ismagil Habibullin, Kostyantyn Zheltukhin, Metin Gürses, Pavlov M. V., Sklyanin E. K., Tsarev S. P.   +7 more
core   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Periodic boundary conditions on the pseudosphere

, 2007
We provide a framework to build periodic boundary conditions on the pseudosphere (or hyperbolic plane), the infinite two-dimensional Riemannian space of constant negative curvature.
Alimohammadi M, Anglès d'Auriac J C, Baek S K, Beardon A F, Belo L R A Oliveira-Neto N M Moura-Melo W A Pereira A R Ercolessi E, Birrel N B, Comtet A, Coxeter H S M, Coxeter H S M, Doyon B, F Sausset, Frenkel D, G Tarjus, Giomi L Bowick M J, Hansen J P, Hasegawa I Sakaniwa Y Shima H, Hilbert D, Klein F, Kléman M, Landau D P, Magnus W, Nakahara M, Nechaev S, Nelson D R, Poincaré H, Rietman R, Sadoc J-F, Sausset F Tarjus G Viot P, Shima H, Shima H, Tarjus G, Ueda K Krcmar R Gendiar A Nishino T, Yuncken R   +32 more
core   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Quantum detection of boundary conditions

Physics Letters B
The quantum detection of spacetime conicity was investigated in reference Cong et al. (2021) [9] through the analysis of the response function of an Unruh-deWitt detector coupled to a massless scalar field.
Jefferson Monção da Silva, João Paulo M. Pitelli   +1 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Nonlocal problems for hyperbolic equations from the viewpoint of strongly regular boundary conditions

Electronic Journal of Differential Equations, 2020
In this article, we consider a nonlocal problem for hyperbolic equation with integral conditions and show their close connection with the notion of strongly regular boundary conditions.
Ludmila S. Pulkina
doaj