Results 71 to 80 of about 648,510 (309)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Quantum detection of boundary conditions
Physics Letters BThe quantum detection of spacetime conicity was investigated in reference Cong et al. (2021) [9] through the analysis of the response function of an Unruh-deWitt detector coupled to a massless scalar field.
Jefferson Monção da Silva +1 more
doaj +1 more source
Conjugate boundary value problems with functional boundary conditions at resonance
Boundary Value Problems, 2019 By constructing a suitable projection scheme and using the coincidence degree theory of Mawhin, we study the existence of solutions for conjugate boundary value problems with functional boundary conditions at resonance with dimKerL=1 $\operatorname{dim ...
Weihua Jiang, Jing Qiu, Bingzhi Sun
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Boundary condition of polyelectrolyte adsorption [PDF]
Physical Review E, 2006 The modification of the boundary condition for polyelectrolyte adsorption on charged surface with short-ranged interaction is investigated under two regimes. For weakly charged Gaussian polymer in which the short-ranged attraction dominates, the boundary condition is the same as that of the neutral polymer adsorption.
openaire +3 more sources
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Electronic Journal of Differential Equations, 2020 In this article, we consider a nonlocal problem for hyperbolic equation with integral conditions and show their close connection with the notion of strongly regular boundary conditions.
Ludmila S. Pulkina
doaj
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Trial methods for Bernoulli's free boundary problem [PDF]
, 2014 Free boundary problems deal with solving partial differential equations in a domain, a part of whose boundary is unknown – the so-called free boundary. Beside the standard boundary conditions that are needed in order to solve the partial differential ...
Mitrou, Giannoula
core +1 more source
Magnetohydrodynamic channel flow and variational principles
International Journal of Mathematics and Mathematical Sciences, 1987 This paper deals with magnetohydrodynamic channel flow problems. Attention is given to a variational principle where the boundary conditions are incorporated via a suitable functional which is stationary at the solution of the given problem; the trial ...
Adnan A. El-Hajj
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source