Results 81 to 90 of about 2,653,054 (281)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Magnetohydrodynamic channel flow and variational principles

International Journal of Mathematics and Mathematical Sciences, 1987
This paper deals with magnetohydrodynamic channel flow problems. Attention is given to a variational principle where the boundary conditions are incorporated via a suitable functional which is stationary at the solution of the given problem; the trial ...
Adnan A. El-Hajj
doaj   +1 more source

On singular $p$-Laplacian boundary value problems involving integral boundary conditions

Electronic Journal of Qualitative Theory of Differential Equations, 2019
We prove the existence of positive solutions for the $p$-Laplacian equations \[-(\phi (u^{\prime }))^{\prime }=\lambda f(t,u),\qquad t\in (0,1) \] with integral boundary conditions. Here $\lambda $ is a positive parameter, $\phi (s)=|s|^{p-2}s,p>1,\ f:(0,
Dang Dinh Hai, Xiao Wang
doaj   +1 more source

Vacuum Energy and Renormalization on the Edge

, 2007
The vacuum dependence on boundary conditions in quantum field theories is analysed from a very general viewpoint. From this perspective the renormalization prescriptions not only imply the renormalization of the couplings of the theory in the bulk but ...
Affleck I, Albuquerque L C, Asorey M, Asorey M, Asorey M Esteve J G Sierra G, Cardy J, Casimir H B G, D García-Álvarez, Elizalde E, J M Muñoz-Castañeda, M Asorey, Milton K A, Mintz B, Moss I G, Odintsov S D, Romeo A, Tsutsui I Fülöp T, Zuber J B Petkova V B   +17 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Positive solutions of singular Hadamard-type fractional differential equations with infinite-point boundary conditions or integral boundary conditions

Advances in Difference Equations, 2019
We establish the existence of positive solutions to a class of a singular nonlinear Hadamard-type fractional differential equations with infinite-point boundary conditions (BCs) or integral BCs.
A. M. A. El-Sayed, F. M. Gaafar
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Nonlinear Schrodinger equations on the half-line with nonlinear boundary conditions

Electronic Journal of Differential Equations, 2016
In this article, we study the initial boundary value problem for nonlinear Schrodinger equations on the half-line with nonlinear boundary conditions $$ u_x(0,t)+\lambda|u(0,t)|^ru(0,t)=0,\quad \lambda\in\mathbb{R}-\{0\},\; r> 0.
Ahmet Batal, Turker Ozsari
doaj  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source