Results 41 to 50 of about 1,137,944 (246)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Finite element approximation of source term identification with TV-regularization

, 2019
In this paper we investigate the problem of recovering the source term in an elliptic system from a measurement of the state on a part of the boundary.
Hinze, Michael, Quyen, Tran Nhan Tam
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Boundary Element Method for the Helmholtz Equation

Journal of Mathematical Extension, 2015
The boundary element methos is applied to the Helholtltz equation. To this end we discretized the Helmholtz equation over the boundary Ω and conclude a system of equations.
A. Mesforush, Z. Mehraban
doaj  

Element-Free Galerkin Scaled Boundary Method Based on Moving Kriging Interpolation for Steady Heat Conduction Analysis with Temperatures on Side-Faces

Shanghai Jiaotong Daxue xuebao, 2021
The element-free Galerkin scaled boundary method (EFG-SBM) based on moving Kriging (MK) interpolation is used to solve steady heat conduction problems with temperature loads on side-faces, in which the circumferential boundary is discretized based on MK ...
WANG Feng, CHEN Jiali, CHEN Denghong, FAN Yong, LI Zhiyuan, HE Weiping
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Sliding frame-solid interaction using BEM/FEM coupling

Latin American Journal of Solids and Structures
In this work it is presented a coupling between the Boundary Element Method (BEM) and the Finite Element Method (FEM) for two-dimensional elastostatic analysis of frame-solid interaction.
Fabio Carlos da Rocha, Wilson Sergio Venturini, Humberto Breves Coda   +2 more
doaj   +1 more source

Analysis of arching around shallow tunnels using the boundary element approach [PDF]

, 2010
This paper describes a study of the effect of soil arching around shallow tunnels using the Boundary Element Method. Due to the different stiffnesses of the soil and the underground structure, then, under surface loading, the differential displacements ...
Davies, T.G., Kamchoom, V.
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source