Results 51 to 60 of about 1,137,944 (246)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

The Global Element Method for Three- Dimensional Potential Problems

open access: yesIEEE Access
This paper presents the Global Element Method (GEM) for solving three-dimensional potential problems. Compared to traditional boundary element methods, this approach offers significant advantages.
Xinrong Li, Chao Zhang, Yaoming Zhang
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Sensitivity analysis of non-uniform rational B-splines–based finite element/boundary element coupling in structural-acoustic design

open access: yesFrontiers in Physics
For the purpose of modeling the acoustic fluid-structure interaction using direct differentiation method and conducting a structural-acoustic sensitivity analysis, a coupling approach based on the finite element method and the fast multipole boundary ...
Yanming Xu, Sen Yang, Sen Yang
doaj   +1 more source

Application of the Green Element Method to Chemical Engineering Problems

open access: yesJournal of King Saud University: Engineering Sciences, 2004
The novel Green element method (GEM), which applies the singular boundary integral theory (a Fredholm integral equation of the second kind) on each element at a time, is herein implemented on chemical engineering problems.
M.E.E. Abashar
doaj   +1 more source

Symmetric Galerkin boundary element method. [PDF]

open access: yes, 1998
This review concerns a methodology for solving numerically, to engineering purposes, boundary and initial-boundary value roblems by a peculiar approach characterized by the following features: the continuous formulation is centered on integral equations ...
Bonnet, Marc, Maier, G., Polizzotto, C.
core   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

RETRACTED : Composite parameters analysis with boundary element method

open access: yesJournal of Materials and Engineering Structures, 2019
This article has been retracted at the request of the Editors-in-Chief, according to the Publication Ethics Policy and Publication Malpractice Statement.
Ahmed SAHLI   +2 more
doaj  

Probabilistic boundary element method [PDF]

open access: yes
The purpose of the Probabilistic Structural Analysis Method (PSAM) project is to develop structural analysis capabilities for the design analysis of advanced space propulsion system hardware.
Cruse, T. A., Raveendra, S. T.
core   +1 more source

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