Results 61 to 70 of about 1,137,944 (246)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Evolutionary computation in optimization and identification

Computer Assisted Methods in Engineering and Science, 2023
The aim of the paper is to present the application of the evolutionary algorithms to selected optimization and identification problems of mechanical systems. The coupling of evolutionary algorithms with the finite element method and the boundary element
Tadeusz Burczyński, Witold Beluch, Adam Długosz, Wacław Kuś, Marek Nowakowski, Piotr Orantek   +5 more
doaj  

COUPLING BOUNDARY ELEMENT METHOD WITH LEVEL SET METHOD TO SOLVE INVERSE PROBLEM

Informatyka, Automatyka, Pomiary w Gospodarce i Ochronie Środowiska, 2017
The boundary element method and the level set method can be used in order to solve the inverse problem for electric field. In this approach the adjoint equation arises in each iteration step.
Tomasz Rymarczyk, Paweł Tchórzewski, Jan Sikora   +2 more
doaj   +1 more source

n-sided polygonal hybrid finite elements involving element boundary integrals only for anisotropic thermal analysis

Archives of Mechanics, 2020
As a combination of the traditional finite element method and boundary element method, the n-sided polygonal hybrid finite element method with fundamental solution kernels, named as HFS-FEM, is thoroughly studied in this work for two-dimensional heat ...
R.F. Cao, X.J. Zhao, W.Q. Lin, H. Wang
doaj   +1 more source

Composite micromechanical modeling using the boundary element method [PDF]

The use of the boundary element method for analyzing composite micromechanical behavior is demonstrated. Stress-strain, heat conduction, and thermal expansion analyses are conducted using the boundary element computer code BEST-CMS, and the results ...
Goldberg, Robert K., Hopkins, Dale A.
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

STRUCTURAL SHAPE OPTIMIZATION BY ISOGEOMETRIC BOUNDARY ELEMENT METHOD

Jixie qiangdu, 2019
In Isogeometric boundary element method（IGA-BEM）, Non-Uniform Rational B-Splines（NURBS） which are used for describing the geometric boundary in a computer-aided geometric design（CAGD） are employed as shape functions of Boundary Element Method.
SUN ShaoHui, YIN ShuoHui
doaj  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Multilevel quadrature for elliptic problems on random domains by the coupling of FEM and BEM [PDF]

, 2018
Elliptic boundary value problems which are posed on a random domain can be mapped to a fixed, nominal domain. The randomness is thus transferred to the diffusion matrix and the loading.
Harbrecht, Helmut, Schmidlin, Marc
core   +1 more source

Helical swimming in Stokes flow using a novel boundary-element method

, 2013
We apply the boundary-element method to Stokes flows with helical symmetry, such as the flow driven by an immersed rotating helical flagellum. We show that the two-dimensional boundary integral method can be reduced to one dimension using the helical ...
Breuer, Kenneth S., Liu, Bin, Powers, Thomas R.   +2 more
core   +1 more source