Results 111 to 120 of about 4,570,639 (247)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Recommendations for woeks to preserve for the Rio Grande its character as the International Boundary in the reach from Cajoncitos, Chihuahua to Haciendita, Texas

, 1979
No ...
International Boundary and Water Commission
core  

A graph model to describe the network connectivity of trabecular plates and rods

Frontiers in Bioengineering and Biotechnology
Introduction: The trabecular network is perceived as a collection of interconnected plate- (P) and rod-like (R) elements. Previous research has highlighted how these elements and their connectivity influence the mechanical properties of bone, yet further
Matthias Walle, Matthias Walle, Diana Yeritsyan, Mohammadreza Abbasian, Ramin Oftadeh, Ralph Müller, Ara Nazarian, Ara Nazarian   +7 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Numerical Modeling of a Boundary Value Problem for a Singularly Perturbed Differential Equation with Two Boundary Layers Using the Spectral-Grid Method

Computation
This paper proposes a spectral-grid method based on Chebyshev polynomials of the first kind for the numerical solution of second-order singularly perturbed boundary value problems containing two boundary layers.
Chori Begaliyevich Normurodov, Sardorbek Komil o’g’li Murodov, Muhriddin Amanturdiyevich Tilovov, Nasiba Turaxanovna Djurayeva, Mohira Majidovna Normatova, Elvira Erkin qizi Shakayeva   +5 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Modeling of fluid flow in periodic cell with porous cylinder using a boundary element method [PDF]

, 2016
© 2016 Elsevier Ltd. All rights reserved.The problem of viscous incompressible flow past a periodic array of porous cylinders (a model of flow in an aerosol filter) is solved. The approximate periodic cell model of Kuwabara is used to formulate the fluid
Mardanov R., Zaripov S., Dunnett S.
core  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Chromosome boundary elements and regulation of heterochromatin spreading. [PDF]

Cell Mol Life Sci, 2014
Wang J, Lawry ST, Cohen AL, Jia S.
europepmc   +1 more source