Results 91 to 100 of about 215,554 (316)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Archives of Mechanics, 2020 As a combination of the traditional finite element method and boundary element method, the n-sided polygonal hybrid finite element method with fundamental solution kernels, named as HFS-FEM, is thoroughly studied in this work for two-dimensional heat ...
R.F. Cao, X.J. Zhao, W.Q. Lin, H. Wang
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Analyzing static three-dimensional elastic domains with a new infinite boundary element formulation
, 2010 A new two-dimensionally mapped infinite boundary element (IBE) is presented. The formulation is based on a triangular boundary element (BE) with linear shape functions instead of the quadrilateral IBEs usually found in the literature. The infinite solids
RIBEIRO, Dimas Betioli +1 more
core +1 more source
Boundary element analysis of stiffened panels with repair patches [PDF]
, 2015 In this paper a boundary element method for analysis of fractured stiffened panels repaired with riveted or adhesively bonded patches is presented. In order to achieve such a formulation, several boundary element formulations involving the membrane and ...
Aliabadi, MH, Di Pisa, C
core +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Engineering Analysis with Boundary Elements
This journal is specifically dedicated to the dissemination of the latest developments of new engineering analysis techniques using boundary elements and other mesh reduction methods.
Ballestra Luca Vincenzo
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上海师范大学学报. 自然科学版, 2017 The hydrogenation-disproportionation-desorption-recombination (HDDR) process is the main technique for the fabrication of anisotropic NdFeB magnetic powder.But the intrinsic coercivity (HC) of HDDR magnetic powder is low.The addition of heavy rare earth ...
Lyu Meng +5 more
doaj +1 more source
A second order convergent trial method for a free boundary problem in three dimensions [PDF]
, 2015 The present article is concerned with the solution of a generalized Bernoulli free boundary problem in three spatial dimensions. We parametrize the free boundary under consideration over the sphere and apply a trial method which updates the free boundary
Harbrecht, Helmut, Bugeanu, Monica
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FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source