Results 41 to 50 of about 62,591 (316)
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
An experimental investigation of the recirculation zone formed downstream of a forward facing step [PDF]
, 2010 An experimental investigation of the recirculation zone formed downstream of a forward facing step immersed in a turbulent boundary layer has been undertaken using particle image velocimetry.
J. Sheridan +5 more
core +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Flow over a cylinder with a small triangular bump
FlowThe surface pressure distribution over a circular cylinder with a small, full-span, triangular bump is examined. The geometry of the bump is an isosceles triangle, the height of which is varied from 1.33 % to 5.33 % of the diameter of the cylinder and ...
Jack Elliott +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
气体物理, 2023 In order to explore the effect of entropy layer on swept shock/turbulent boundary layer interaction, numerical simulation was applied to study a fin/blunt plate physical model.
Xian-kai LI +6 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Stagnation point flow and heat transfer over a nonlinear shrinking sheet with slip effects
Alexandria Engineering Journal, 2015 In this paper, an investigation is performed to analyze the effects of the slip parameters A and B on the steady stagnation-point flow and heat transfer due to a shrinking sheet in a viscous and incompressible fluid. Using similarity transformations, the
N.F. Fauzi, S. Ahmad, I. Pop
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Passive Transonic Shock Control on Bump Flow for Wing Buffet Suppression
Aerospace, 2023 Since modern transport aircraft cruise at transonic speeds, shock buffet alleviation is one indispensable challenge that civil transport research needs to be addressed.
Davide Di Pasquale, Simon Prince
doaj +1 more source