Results 61 to 70 of about 458,946 (359)

Unsteady separation in vortex-induced boundary layers [PDF]

Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2014
This paper provides a brief review of the analytical and numerical developments related to unsteady boundary-layer separation, in particular as it relates to vortex-induced flows, leading up to our present understanding of this important feature in high-Reynolds-number, surface-bounded flows in the presence of an adverse pressure gradient.
Cassel, K. W., Conlisk, A. T.
openaire   +3 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A Study on the Separation Length of Shock Wave/Turbulent Boundary Layer Interaction

International Journal of Aerospace Engineering, 2019
The separation length of shock wave/boundary layer interaction (SWBLI) was studied by a numerical method, which was validated by experimental results. The computational domain was two-dimensional (2-D).
Yong-yi Zhou, Yi-long Zhao, Yu-xin Zhao
doaj   +1 more source

An experimental investigation of the recirculation zone formed downstream of a forward facing step [PDF]

, 2010
An experimental investigation of the recirculation zone formed downstream of a forward facing step immersed in a turbulent boundary layer has been undertaken using particle image velocimetry.
Lo Jacono, David, Sheridan, John, Sherry, Michael   +2 more
core   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Effects of Surface Roughness on the Flow of High-Lift Low-Pressure Turbine

Journal of Harbin University of Science and Technology, 2019
In order to get the effects of surface roughness on turbine profile loss in different working conditions, the flow of a frontloaded blade at different incidences and different Reynolds number was analyzed in detail by numerical simulation The results ...
ZHANG Zong-chen, QIAO Wei-yang, BAI Tao
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Numerical Investigation of Jet Angle Effect on Airfoil Stall Control

Applied Sciences, 2019
Numerical study on flow separation control is conducted for a stalled airfoil with steady-blowing jet. Stall conditions relevant to a rotorcraft are of interest here.
Junkyu Kim, Young Min Park, Junseong Lee, Taesoon Kim, Minwoo Kim, Jiseop Lim, Solkeun Jee   +6 more
doaj   +1 more source

Three-dimensional characteristics of crossing shock wave/turbulent boundary layer interaction in a double fin with and without micro-ramp control

AIP Advances, 2022
The three-dimensional (3D) interactions between crossing shock waves and a turbulent boundary layer (CSWBLI) inside a symmetric double fin are experimentally studied using nanoparticle-based planar laser scattering, supersonic particle image velocimetry,
Lican Wang, Yilong Zhao, Qiancheng Wang, Yuxin Zhao, Ruoling Zhang, Li Ma   +5 more
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source