Results 71 to 80 of about 63,038 (316)

Spatial DNS of an Isothermal Flat Plate Supersonic Turbulent Boundary Layer with/out Impinging Shock Wave

open access: yesJournal of Fluid Science and Technology, 2011
Spatial direct numerical simulation results are presented for transitional/turbulent supersonic isothermal flat plate boundary layers at M = 2.0 and impinging shock wave-boundary layer interactions.
Yusuke TOKURA, Hiroshi MAEKWA
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Theory and computations for breakup of unsteady subsonic or supersonic separating flows

open access: yes, 1994
This study of flow just beyond a breakaway-separation point presents a description of planar nonlinear unsteady effects over a fairly wide parameter range, for a subsonic or supersonic boundary layer at large Reynolds numbers.
Vickers, IP   +3 more
core   +1 more source

Eliminating Boundary Layer Separation on a Cylinder with Nonuniform Suction

open access: yesInternational Journal of Aerospace Engineering, 2020
Boundary layer separation negatively influences the performance of aerospace vehicles, for example, by triggering static stall or reducing combustion engine efficiency.
James Ramsay   +2 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

Transitional separation bubbles and unsteady aspects of aerofoil stall [PDF]

open access: yes, 2008
A time-accurate solution method for the coupled potential flow and integral boundary-layer equations is used to study aerofoils near stall, where laboratory experiments have shown high-amplitude low-frequency oscillations.
Sandham, N.D.
core  

Hypersonic interference heating in the vicinity of surface protuberances [PDF]

open access: yes, 2010
The understanding of the behaviour of the flow around surface protuberances in hypersonic vehicles is developed and an engineering approach to predict the location and magnitude of the highest heat transfer rates in their vicinity is presented.
Garry, Kevin P.   +4 more
core   +1 more source

A Study on the Separation Length of Shock Wave/Turbulent Boundary Layer Interaction

open access: yesInternational Journal of Aerospace Engineering, 2019
The separation length of shock wave/boundary layer interaction (SWBLI) was studied by a numerical method, which was validated by experimental results. The computational domain was two-dimensional (2-D).
Yong-yi Zhou, Yi-long Zhao, Yu-xin Zhao
doaj   +1 more source

Effects of Surface Roughness on the Flow of High-Lift Low-Pressure Turbine

open access: yesJournal of Harbin University of Science and Technology, 2019
In order to get the effects of surface roughness on turbine profile loss in different working conditions, the flow of a frontloaded blade at different incidences and different Reynolds number was analyzed in detail by numerical simulation The results ...
ZHANG Zong-chen, QIAO Wei-yang, BAI Tao
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

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