Results 51 to 60 of about 458,946 (359)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Theory of pressure acoustics with boundary layers and streaming in curved elastic cavities [PDF]

, 2018
The acoustic fields and streaming in a confined fluid depend strongly on the acoustic boundary layer forming near the wall. The width of this layer is typically much smaller than the bulk length scale set by the geometry or the acoustic wavelength, which
Henrik Bruus, Jacob S. Bach, Kreyszig E., Landau L. D., Laurell T., Schlichting H., Yosioka K.   +6 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Dual solutions of slip flow past a nonlinearly shrinking permeable sheet

Alexandria Engineering Journal, 2016
The aim of the paper is to investigate the flow of an incompressible viscous fluid past a nonlinearly shrinking permeable sheet. Partial slip condition is considered instead of no slip condition at the boundary.
Sudipta Ghosh, Swati Mukhopadhyay, Kuppalapalle Vajravelu   +2 more
doaj   +1 more source

Solutions of the Navier–Stokes Equation at Large Reynolds Number [PDF]

, 1975
The problem of two-dimensional incompressible laminar flow past a bluff body at large Reynolds number (R) is discussed. The governing equations are the Navier-Stokes equations. For R = ∞, the Euler equations are obtained. A solution for R large should be
Lagerstrom, Paco A.
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Effect of expansion waves on cowl shock wave and boundary layer interaction in hypersonic inlet

Propulsion and Power Research
The interaction of cowl shock wave and boundary layer has a crucial effect on the stability, operability and performance of hypersonic inlets. Many studies on inhibiting the separation and managing the strength of the interaction of the shock wave and ...
Guangwei Wu, Ziao Wang, Teng Shi, Zhibin Zhang, Weiyu Jiang, Fuxu Quan, Juntao Chang   +6 more
doaj   +1 more source

Description of the Overall Mass Transport during Membrane Gas Separation

Chemical Engineering Transactions, 2014
Concentration polarization has often been observed in membrane gas separation when there is an accumulation of the less permeable species and a depletion of the more permeable components in the boundary layer of the fluid phase as a result of high fluxes
E. Nagy, I. Hegedüs
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Spatial DNS of an Isothermal Flat Plate Supersonic Turbulent Boundary Layer with/out Impinging Shock Wave

Journal of Fluid Science and Technology, 2011
Spatial direct numerical simulation results are presented for transitional/turbulent supersonic isothermal flat plate boundary layers at M = 2.0 and impinging shock wave-boundary layer interactions.
Yusuke TOKURA, Hiroshi MAEKWA
doaj   +1 more source