Results 71 to 80 of about 32,928 (252)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Confidence intervals for the difference and the ratio of Lognormal means with bounded parameters [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2015
In this paper, confidence intervals for the difference between lognormal means and the ratio of lognormal means with restricted parameter spaces are proposed.
Sa-aat Niwitpong
doaj  

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Finite Time Bounds for Stochastic Bounded Confidence Dynamics

IEEE Transactions on Network Science and Engineering
In this era of fast and large-scale opinion formation, a mathematical understanding of opinion evolution, a.k.a. opinion dynamics, acquires importance. Linear graph-based dynamics and bounded confidence dynamics are the two popular models for opinion dynamics in social networks.
Sushmitha Shree S, Avhishek Chatterjee, Krishna P. Jagannathan   +2 more
openaire   +2 more sources

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Complex Transitions of the Bounded Confidence Model from an Odd Number of Clusters to the Next

Physics
The bounded confidence model assumes simple continuous opinion dynamics in which agents ignore opinions which are too far from their own. The two initial variants—Hegselmann–Krause (HK) and Deffuant–Weisbuch (DW)—of the model have attracted significant ...
Guillaume Deffuant
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Quantifying opinion homophily in online social networks from a bounded confidence perspective

Communications Physics
Homophily is pervasive in online social media. While many empirical studies have relied on external sociodemographic traits to investigate it, significantly less is known about homophily at the cognitive level, that is, at the level of shared opinions or
Yangyang Luan, Camilla Ancona, Carmela Bernardo, Valentina Pansanella, Francesco Lo Iudice, Giulio Rossetti, Francesco Vasca, Xiaoqun Wu, Claudio Altafini   +8 more
doaj   +1 more source

Inference with the Upper Confidence Bound Algorithm

CoRR
17 pages, 1 ...
Koulik Khamaru, Cun-Hui Zhang
openaire   +2 more sources