Results 51 to 60 of about 1,528,765 (246)

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Modeling and Simulation of Opinion Natural Reversal Dynamics with Opinion Leader Based on HK Bounded Confidence Model

Complexity, 2020
Opinion natural reversals are important and common phenomena in network management. It is a naturally emerging process of opinions characterized by interactions between individuals and the evolution of attitudes themselves.
Renbin Xiao, Tongyang Yu, Jundong Hou
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Modified Hegselmann-Krause Model for Enhancing Opinion Diversity in Social Networks

IEEE Access
A goal of opinion dynamics modelers has long been to find a social science based model that generates strong diversity: smooth, stable, possibly multi-modal distributions of opinions.
Chun Cheng, Jiahao Gu, Siyan Lu, Weiping Ding   +3 more
doaj   +1 more source

Economic Benefits of Critical Habitat for the Mexican Spotted Owl: A Scope Test Using a Multiple-Bounded Contingent Valuation Survey

Journal of Agricultural and Resource Economics, 1997
A split-sample design is used to test for a difference between mean willingness to pay (WTP) for protecting the Mexican spotted owl versus protecting 62 threatened/endangered species which includes the Mexican spotted owl. The multiple bounded contingent
John B. Loomis, Earl Ekstrand
doaj   +1 more source

Compact well-bounded operators [PDF]

, 2001
Every compact well-bounded operator has a representation as a linear combination of disjoint projections reminiscent of the representation of compact self-adjoint operators. In this note we show that the converse of this result holds, thus characterizing
Qingping, C., Doust, I.
core  

Bounded confidence, radical groups, and charismatic leaders

, 2021
By few simple extensions it is possible to model radical groups, charismatic leaders and processes of radicalization in the bounded confidence framework. In the resulting model we get a lot of surprising (non-)monotonicities.
Hegselmann, Rainer
core  

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

A common mechanism underlies changes of mind about decisions and confidence

eLife, 2016
Decisions are accompanied by a degree of confidence that a selected option is correct. A sequential sampling framework explains the speed and accuracy of decisions and extends naturally to the confidence that the decision rendered is likely to be correct.
Ronald van den Berg, Kavitha Anandalingam, Ariel Zylberberg, Roozbeh Kiani, Michael N Shadlen, Daniel M Wolpert   +5 more
doaj   +1 more source