Results 101 to 110 of about 750,144 (292)
Evaluation of synaptotagmin‐1 action models by all‐atom molecular dynamics simulations
FEBS Open Bio, EarlyView.We used molecular dynamics simulations to test models proposing that synaptotagmin‐1 facilitates membrane fusion by perturbing lipid bilayers, inducing membrane curvature and/or bridging membranes. The simulations show that synaptotagmin‐1 C2‐domains placed near the site of fusion hinder the ability of SNARE complexes to bring the membranes together ...
Josep Rizo +2 more
wiley +1 more source
Demonstratio Mathematica, 2019 In the paper we investigate slice holomorphic functions F : ℂn → ℂ having bounded L-index in a direction, i.e. these functions are entire on every slice {z0 + tb : t ∈ℂ} for an arbitrary z0 ∈ℂn and for the fixed direction b ∈ℂn \ {0}, and (∃m0 ∈ ℤ+) (∀m ∈
Bandura Andriy +2 more
doaj +1 more source
On Riemann Surfaces, on which no Bounded 4 Harmonic Function Exists [PDF]
, 1951 Akira Mori
openalex +1 more source
FEBS Open Bio, EarlyView.FAM136A depletion upregulated ROS production, reduced mitochondrial membrane potential (ΔΨ) and ATP production, and upregulated expression of PCK1, PCK2, HMGCS1, and HMGCS2. The expression of both TOMM22 and TOMM20 was also upregulated. FAM136A depletion reduced HCCS that produce holocytochrome c by combining heme to apocytochrome c, and reduced the ...
Yushi Otsuka, Masato Yano
wiley +1 more source
Phenotypic continuum of NFU1‐related disorders
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 2025-2035, December 2022., 2022 Abstract Bi‐allelic variants in Iron–Sulfur Cluster Scaffold (NFU1) have previously been associated with multiple mitochondrial dysfunctions syndrome 1 (MMDS1) characterized by early‐onset rapidly fatal leukoencephalopathy. We report 19 affected individuals from 10 independent families with ultra‐rare bi‐allelic NFU1 missense variants associated with a
Rauan Kaiyrzhanov +45 more
wiley +1 more source
Bounds on the bias terms for the Markov reward approach [PDF]
arXiv, 2019 An important step in the Markov reward approach to error bounds on stationary performance measures of Markov chains is to bound the bias terms. Affine functions have been successfully used for these bounds for various models, but there are also models for which it has not been possible to establish such bounds.
arxiv
On Representations and Extensions of Bounded Linear Functionals Defined on Classes of Analytic Functions [PDF]
, 1954 Philip J. Davis, J. L. Walsh
openalex +1 more source
FEBS Open Bio, EarlyView.IDMF is a derivative of dimethyl fumarate (DMF) with a unique therapeutic potential at the intersection of psoriasis and multiple sclerosis. Here, we demonstrate that it compares favorably with DMF and its other derivatives, such as Diroximel, in the zebrafish, microglia, and lymphocyte models.
Yulin He +5 more
wiley +1 more source
The clinical spectrum of SMA‐PME and in vitro normalization of its cellular ceramide profile
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1941-1952, December 2022., 2022 Abstract Objective The objectives of this study were to define the clinical and biochemical spectrum of spinal muscular atrophy with progressive myoclonic epilepsy (SMA‐PME) and to determine if aberrant cellular ceramide accumulation could be normalized by enzyme replacement.
Michelle M. Lee +16 more
wiley +1 more source
New Approximation Formula of Digamma Function with Bounded Remainder
MathematicsThis study establishes the new approximation formula for the Digamma function ψ(s)=lns−12s−112ss2+θ(s ...
Mansour Mahmoud +2 more
doaj +1 more source