Results 91 to 100 of about 5,509,463 (298)
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Which solutions of the third problem for the Poisson equation are bounded?
Abstract and Applied Analysis, 2004 This paper deals with the problem Δu=g on G and ∂u/∂n+uf=L on ∂G. Here, G⊂ℝm, m>2, is a bounded domain with Lyapunov boundary, f is a bounded nonnegative function on the boundary of G, L is a bounded linear functional on W1,2(G) representable by a real ...
Dagmar Medková
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Structural stability and robustness to bounded rationality
, 2000 The introduction of a small amount of bounded rationality into a model sometimes has little effect, and sometimes has a dramatic impact on predicted behavior.
Canning, David, Anderlini, Luca
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Improved approximation algorithms for degree-bounded network design problems with node connectivity requirements [PDF]
, 2014 We consider degree bounded network design problems with element and vertex connectivity requirements. In the degree bounded Survivable Network Design (SNDP) problem, the input is an undirected graph G = (V, E) with weights w(e) on the edges and degree ...
Ali Vakilian +3 more
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Boundary functions for bounded harmonic functions [PDF]
Transactions of the American Mathematical Society, 1969 Let D be the open unit disk in the complex plane and let C be its boundary, the unit circle. If 4 E C, then by an arc at t we mean a simple arc y with one endpoint at 4 such that y { } ( D. In this paper we use the term boundazy function in the following sense.
openaire +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Coefficients estimates of some subclasses of analytic functions related with conic domain
Analele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2013 In this paper, the authors determine the coefficient bounds for functions in certain subclasses of analytic functions related with the conic regions, which are introduced by using the concept of bounded boundary and bounded radius rotations.
Malik Sarfraz Nawaz +3 more
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Non-homogeneous directional equations: Slice solutions belonging to functions of bounded $L$-index in the unit ball [PDF]
Mathematica BohemicaFor a given direction $ b\in\mathbb{C}^n\setminus\{0\}$ we study non-homogeneous directional linear higher-order equations whose all coefficients belong to a class of joint continuous functions which are holomorphic on intersection of all directional ...
Andriy Bandura +2 more
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