Results 81 to 90 of about 1,241,136 (285)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Which solutions of the third problem for the Poisson equation are bounded?

Abstract and Applied Analysis, 2004
This paper deals with the problem Δu=g on G and ∂u/∂n+uf=L on ∂G. Here, G⊂ℝm, m>2, is a bounded domain with Lyapunov boundary, f is a bounded nonnegative function on the boundary of G, L is a bounded linear functional on W1,2(G) representable by a real ...
Dagmar Medková
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Entire functions of bounded index in frame

Математичні Студії, 2020
We introduce a concept of entire functions having bounded index in a variable direction, i.e. in a frame. An entire function $F\colon\ \mathbb{C}^n\to \mathbb{C}$ is called a function of bounded frame index in a frame $\mathbf{b}(z)$, if~there exists ...
A.I. Bandura
doaj   +1 more source

Bounds for automorphic L-functions. III

Inventiones Mathematicae, 1994
[Part I, cf. ibid. 112, 1-8 (1993; Zbl 0765.11038).] This is the second in a series of papers developing the authors' method for bounding automorphic \(L\)-functions at a point on the critical line. Such \(L\)-functions possess a functional equation due to Hecke which may be combined with the Phragmen-Lindelöf principle to yield the so-called convexity
Iwaniec, H., Duke, W., Firedlander, J.B.
openaire   +3 more sources

Spectral triples and finite summability on Cuntz-Krieger algebras [PDF]

, 2015
We produce a variety of odd bounded Fredholm modules and odd spectral triples on Cuntz-Krieger algebras by means of realizing these algebras as "the algebra of functions on a non-commutative space" coming from a sub shift of finite type. We show that any
Goffeng, Magnus, Mesland, Bram
core   +2 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source