Results 41 to 50 of about 5,611 (266)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

A Generalized Norm on Reproducing Kernel Hilbert Spaces and Its Applications

Axioms, 2023
The aim of this article was to provide improved estimates for the (α,β)-norm of a bounded linear operator. In particular, our results enabled the determination of new upper bounds involving both the Berezin number and the Berezin norm of bounded linear ...
Najla Altwaijry, Kais Feki, Nicuşor Minculete   +2 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Approximation of functions with linear positive operators which fix {1, φ} and {1, φ2}

Analele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2020
In this manuscript, linear and positive operators described on bounded and unbounded intervals that fix the function sets {1, φ} and {1, φ2} such that φ ∈ C[0, 1] are presented. Then we present different types of operators by choosing different functions
Usta Fuat
doaj   +1 more source

One Parameter Composite Semigroups of Linear Bounded Operators in Strong Operator Topology of Schatten Class Cp [PDF]

Engineering and Technology Journal, 2011
For semigroups of linear bounded operators on Hilbert spaces, the problem of being in Cp , 0 ...
Samir Kasim Hassan, Al-Taie M, Al-Malki Anam, Al-Attar Abeer, Mustafa Khaleel Ismael, Fatema Ahmed Sadeq, Radhi A .Zboon, Jehad R.Kider, Samir K .Hassan, Hussain J. M. Alalkawi, Raad H. Majid, Rawaa A. Alomairy, Luma Abdul Ghani Zghair, Hadia Kadhim J.Al-Ogili, Assifa M. Mohamad, Abbas Sheyaa Alwan, Haider L. Aneed, Assim H Yousif, Salema Sultan Salman, Abbas Hussien Miry, Abduladhem A.Ali, Mohammed Zeki Al-Faiz, Sabah N. mahmood, Khansaa Dawood Selman, Shaymaa Tareq Kadhim   +24 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Modules and Bounded Linear Operators

Journal of Al-Nahrain University-Science, 2016
An associated R-module of T, which is denoted by V_(T,T^* ) is given, Where V is an inner product space and T is bounded linear operator on V. We study in this paper properties of T which effects V_(T,T^* ) and conversely.
Muna Jasim, Manal Ali
openaire   +2 more sources