Results 91 to 100 of about 142,415 (276)
Molecular Oncology, EarlyView.Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit +19 more
wiley +1 more source
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
On the boundedness of topological categories [PDF]
Manuscripta Mathematica, 1974 Let K be a complete and cocomplete category with a given proper (E,M)-factorization. K is called well-bounded if K is moreover bounded with a generator and cowellpowered with respect to the given factorization. Freyd-Kelly proved the following theorem about well-bounded categories: Let K be a well-bounded category and let Γ be a class of cylinders in ...
openaire +2 more sources
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
Boundedness of Vector Linéard Equation with Multiple Variable Delays
MathematicsIn this article, we consider a system of ordinary differential equations (ODEs) of second order with two variable time delays. We obtain new conditions for uniform ultimate bounded (UUB) solutions of the considered system.
Melek Gözen
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Molecular Oncology, EarlyView.Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop +10 more
wiley +1 more source
Data‐driven performance metrics for neural network learning
International Journal of Adaptive Control and Signal Processing, EarlyView., 2023 Summary Effectiveness of data‐driven neural learning in terms of both local mimima trapping and convergence rate is addressed. Such issues are investigated in a case study involving the training of one‐hidden‐layer feedforward neural networks with the extended Kalman filter, which reduces the search for the optimal network parameters to a state ...
Angelo Alessandri +2 more
wiley +1 more source
AIMS MathematicsMathematical formulations are crucial in understanding the dynamics of disease spread within a community. The objective of this research is to investigate the SEIR model of SARS-COVID-19 (C-19) with the inclusion of vaccinated effects for low immune ...
Huda Alsaud +4 more
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Integral type operators from normal weighted Bloch spaces to QT,S spaces
Journal of Hebei University of Science and Technology, 2016 Operator theory is an important research content of the analytic function space theory. The discussion of simultaneous operator and function space is an effective way to study operator and function space.
Yongyi GU, Wenjun YUAN, Fanning MENG
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