Results 111 to 120 of about 187,605 (363)

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Boundedness in a quasilinear two-species chemotaxis system with consumption of chemoattractant

Electronic Journal of Qualitative Theory of Differential Equations, 2019
This paper deals with a two-species chemotaxis system \begin{equation*} \begin{cases} u_t=\nabla\cdot(D_1(u)\nabla u)-\nabla\cdot(u\chi_1(w)\nabla w)+\mu_1 u(1-u-a_1v),\quad &x\in \Omega,\quad t>0,\\ v_t=\nabla\cdot(D_2(v)\nabla v)-\nabla\cdot(v\chi_2(w)\
Jing Zhang, Xuegang Hu, Liangchen Wang, Li Qu   +3 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Existence of Solutions for a Coupled Hadamard Fractional System of Integral Equations in Local Generalized Morrey Spaces

Axioms
This paper introduces a new measure of non-compactness within a bounded domain of RN in the generalized Morrey space. This measure is used to establish the existence of solutions for a coupled Hadamard fractional system of integral equations in ...
Asra Hadadfard, Mohammad Bagher Ghaemi, António M. Lopes   +2 more
doaj   +1 more source

Boundedness of an intrinsic square function on grand $ p $-adic Herz-Morrey spaces

, 2023
Babar Sultan, Mehvish Sultan, Aziz Khan, Thabet Abdeljawad   +3 more
openalex   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

A note on the existence of Psi-bounded solutions for a system of differential equations on R

Electronic Journal of Differential Equations, 2008
We prove a necessary and sufficient condition for the existence of Psi-bounded solutions of a linear nonhomogeneous system of ordinary differential equations on R.
Aurel Diamandescu
doaj  

Mathematical study of polycystic ovarian syndrome disease including medication treatment mechanism for infertility in women

AIMS Public Health
Among women of reproductive age, PCOS (polycystic ovarian syndrome) is one of the most prevalent endocrine illnesses. In addition to decreasing female fertility, this condition raises the risk of cardiovascular disease, diabetes, dyslipidemia, obesity ...
Maryam Batool, Muhammad Farman, Aqeel Ahmad, Kottakkaran Sooppy Nisar   +3 more
doaj   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Global behavior of a discrete population model

AIMS Mathematics
In this work, the global behavior of a discrete population model $ \begin{equation*} \begin{cases} x_{n+1}& = \alpha x_n e^{-y_n}+\beta,\\ y_{n+1}& = \alpha x_n(1-e^{-y_n}), \end{cases}\quad n = 0,1,2,\dots, \end{equation*} $ is considered,
Linxia Hu, Yonghong Shen, Xiumei Jia
doaj   +1 more source