Molnupiravir inhibits Bourbon virus infection and disease-associated pathology in mice. [PDF]
Journal of VirologyBourbon virus (BRBV) is an emerging tick-borne virus that can cause severe and fatal disease in humans. BRBV is vectored via the Amblyomma americanum tick, which is widely distributed throughout the central, eastern, and southern United States ...
Adrianus Boon, Gayan Bamunuarachchi
exaly +4 more sources
Essential Role of Interferon Response in Containing Human Pathogenic Bourbon Virus. [PDF]
Emerging Infectious Diseases, 2019 Bourbon virus (BRBV) is a recently discovered tick-transmitted viral pathogen that is prevalent in the Midwest and southern United States. Since 2014, zoonotic BRBV infections have been verified in several human cases of severe febrile illness ...
Maximilian Seidl +2 more
exaly +4 more sources
Ticks and Tick-borne Diseases, 2023 Heartland and Bourbon viruses are pathogenic tick-borne viruses putatively transmitted by Amblyomma americanum, an abundant tick species in Missouri. To assess the prevalence of these viruses in ticks, we collected 2778 ticks from eight sampling sites at
Houda Harastani +2 more
exaly +3 more sources
Establishment of a Replicon Reporter of the Emerging Tick-Borne Bourbon Virus and Use It for Evaluation of Antivirals [PDF]
Frontiers in Microbiology, 2020 Bourbon virus (BRBV) was first isolated from a patient hospitalized at the University of Kansas Hospital in 2014. Since then, several deaths have been reported to be caused by BRBV infection in the Midwest and Southern United States. BRBV is a tick-borne
Siyuan Hao +7 more
doaj +2 more sources
Therapeutic efficacy of favipiravir against Bourbon virus in mice. [PDF]
PLoS Pathogens, 2019 Bourbon virus (BRBV) is an emerging tick-borne RNA virus in the orthomyxoviridae family that was discovered in 2014. Although fatal human cases of BRBV have been described, little is known about its pathogenesis, and no antiviral therapies or vaccines ...
Traci L Bricker +11 more
doaj +2 more sources
Reverse Vaccinology Integrated with Biophysics Techniques for Designing a Peptide-Based Subunit Vaccine for Bourbon Virus [PDF]
BioengineeringDespite the seriousness of the disease carried by ticks, little is known about the Bourbon virus. Only three US states have recorded human cases of Bourbon virus (BRBV) infection; in all cases, a tick bite was connected with the onset of the illness. The
Taghreed N. Almanaa
doaj +2 more sources
ANP32 proteins from ticks and vertebrates are key host factors for replication of Bourbon virus across species [PDF]
Journal of VirologyBourbon virus (BRBV) is a tick-borne virus in the genus Thogotovirus in the Orthomyxoviridae family. BRBV was initially identified as the presumptive causative agent of a fatal human infection in 2014 and has since been identified in ticks in the Midwest,
Zhenyu Zhang +4 more
doaj +2 more sources
Heartland Virus Infection in Elderly Patient Initially Suspected of Having Ehrlichiosis, North Carolina, USA [PDF]
Emerging Infectious DiseasesWe report a patient in North Carolina, USA, with Heartland virus infection whose diagnosis was complicated by previous Ehrlichia chaffeensis infection. We identified E.
Alexis M. Barbarin +6 more
doaj +2 more sources
Trends in Tick-Borne Virus Ecology: Vector Incrimination, Focal Distribution, and Reservoir Associations [PDF]
VirusesTicks are prominent hosts for many viruses that are pathogenic to humans on almost every continent. Despite the documented historical association of ticks with viral disease in humans, clinical case reports are low, likely due to under-recognition of ...
Rachel E. Lange +2 more
doaj +2 more sources