Results 11 to 20 of about 790 (120)

Eight Years of Research Advances in Bourbon Virus, a Tick-borne Thogotovirus of the Orthomyxovirus Family [PDF]

Zoonoses, 2022
Bourbon virus (BRBV) was first isolated from a blood sample collected from a male patient living in Bourbon County, Kansas, during the spring of 2014. The patient later died because of complications associated with multiorgan failure.
Siyuan Hao, Kang Ning, Çağla Aksu Küz, Shane McFarlin, Fang Cheng, Jianming Qiu   +5 more
doaj   +5 more sources

Therapeutic efficacy of favipiravir against Bourbon virus in mice. [PDF]

PLoS Pathogens, 2019
Bourbon virus (BRBV) is an emerging tick-borne RNA virus in the orthomyxoviridae family that was discovered in 2014. Although fatal human cases of BRBV have been described, little is known about its pathogenesis, and no antiviral therapies or vaccines ...
Traci L Bricker, Md Shafiuddin, Anshu P Gounder, Andrew B Janowski, Guoyan Zhao, Graham D Williams, Brett W Jagger, Michael S Diamond, Thomas Bailey, Jennie H Kwon, David Wang, Adrianus C M Boon   +11 more
doaj   +7 more sources

Reverse Vaccinology Integrated with Biophysics Techniques for Designing a Peptide-Based Subunit Vaccine for Bourbon Virus [PDF]

Bioengineering
Despite the seriousness of the disease carried by ticks, little is known about the Bourbon virus. Only three US states have recorded human cases of Bourbon virus (BRBV) infection; in all cases, a tick bite was connected with the onset of the illness. The
Taghreed N. Almanaa
doaj   +5 more sources

Molnupiravir inhibits Bourbon virus infection and disease-associated pathology in mice [PDF]

Journal of Virology
Bourbon virus (BRBV) is an emerging tick-borne virus that can cause severe and fatal disease in humans. BRBV is vectored via the Amblyomma americanum tick, which is widely distributed throughout the central, eastern, and southern United States ...
Gayan Bamunuarachchi, Fang R. Zhao, Traci L. Bricker, Kuljeet Seehra, Andrew Karp, Michael S. Diamond, Adrianus C. M. Boon   +6 more
doaj   +7 more sources

Prevalence of Bourbon and Heartland viruses in field collected ticks at an environmental field station in St. Louis County, Missouri, USA

Ticks and Tick-Borne Diseases, 2023
Heartland and Bourbon viruses are pathogenic tick-borne viruses putatively transmitted by Amblyomma americanum, an abundant tick species in Missouri. To assess the prevalence of these viruses in ticks, we collected 2778 ticks from eight sampling sites at
Ishmael D. Aziati, Derek McFarland Jnr, Avan Antia, Astha Joshi, Anahi Aviles-Gamboa, Preston Lee, Houda Harastani, David Wang, Solny A. Adalsteinsson, Adrianus C.M. Boon   +9 more
doaj   +5 more sources

Establishment of a Replicon Reporter of the Emerging Tick-Borne Bourbon Virus and Use It for Evaluation of Antivirals [PDF]

Frontiers in Microbiology, 2020
Bourbon virus (BRBV) was first isolated from a patient hospitalized at the University of Kansas Hospital in 2014. Since then, several deaths have been reported to be caused by BRBV infection in the Midwest and Southern United States. BRBV is a tick-borne
Siyuan Hao, Kang Ning, Xiaomei Wang, Jianke Wang, Fang Cheng, Safder S. Ganaie, John E. Tavis, Jianming Qiu   +7 more
doaj   +5 more sources

Heartland Virus Infection in Elderly Patient Initially Suspected of Having Ehrlichiosis, North Carolina, USA [PDF]

Emerging Infectious Diseases
We report a patient in North Carolina, USA, with Heartland virus infection whose diagnosis was complicated by previous Ehrlichia chaffeensis infection. We identified E.
Alexis M. Barbarin, Teresa G. Fisher, Michael H. Reiskind, Carl Williams, Bryan N. Ayres, Kristen L. Burkhalter, William L. Nicholson   +6 more
doaj   +3 more sources

ANP32 proteins from ticks and vertebrates are key host factors for replication of Bourbon virus across species [PDF]

Journal of Virology
Bourbon virus (BRBV) is a tick-borne virus in the genus Thogotovirus in the Orthomyxoviridae family. BRBV was initially identified as the presumptive causative agent of a fatal human infection in 2014 and has since been identified in ticks in the Midwest,
Zhenyu Zhang, Ishmael D. Aziati, Thomas Nipper, Adrianus C. M. Boon, Andrew Mehle   +4 more
doaj   +4 more sources

Experimental Infection of Amblyomma americanum (Acari: Ixodidae) With Bourbon Virus (Orthomyxoviridae: Thogotovirus) [PDF]

Journal of Medical Entomology, 2021
Abstract Following the recent discovery of Bourbon virus (BRBV) as a human pathogen, and the isolation of the virus from Amblyomma americanum (L.) collected near the location of a fatal human case, we undertook a series of experiments to assess the laboratory vector competence of this tick species for BRBV.
Marvin S Godsey, Angela M Bosco-Lauth, Olga I Kosoy   +2 more
exaly   +5 more sources

Widespread Circulation of Tick-Borne Viruses in Virginia—Evidence of Exposure to Heartland, Bourbon, and Powassan Viruses in Wildlife and Livestock [PDF]

Microorganisms
Emerging tick-borne viruses such as Powassan virus (POWV), Bourbon virus (BRBV), and Heartland virus (HRTV), whilst rare, can cause severe health problems in humans.
Ahmed Garba, Jennifer Riley, Kevin K. Lahmers, Gillian Eastwood   +3 more
doaj   +3 more sources