Results 81 to 90 of about 70,515 (216)

First detection of bovine coronavirus in Yak (Bos grunniens) and a bovine coronavirus genome with a recombinant HE gene

Journal of General Virology, 2019
The yak (Bosgrunniens) is a unique domestic bovine species that plays an indispensable role for herdsmen in the Qinghai-Tibet Plateau. Here, 336 diarrhoeic samples were collected from yaks on 29 farms in the Qinghai-Tibet Plateau from 2015 to 2017.
He, Qifu, Guo, Zijing, Zhang, Bin, Yue, Hua, Tang, Cheng   +4 more
openaire   +2 more sources

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Characterization of Winter Dysentery Bovine Coronavirus Isolated from Cattle in Israel

Viruses, 2021
Bovine coronavirus (BCoV) is the causative agent of winter dysentery (WD). In adult dairy cattle, WD is characterized by hemorrhagic diarrhea and a reduction in milk production. Therefore, WD leads to significant economic losses in dairy farms.
Dan David, Nick Storm, Waksman Ilan, Asaf Sol   +3 more
doaj   +1 more source

ZDHHC18‐Mediated Palmitoylation of ORF3a Promotes SARS‐CoV‐2 Pathogenesis by Antagonizing TRIM16‐Mediated Ubiquitination and Proteasomal Degradation

Advanced Science, EarlyView.
Palmitoylation by ZDHHC18 blocks ORF3a K27‐linked ubiquitination mediated by TRIM16, thereby preventing its proteasomal degradation and strengthening viral pathogenesis. Targeting palmitoylation through a pharmacological inhibitor (2‐BP), a competitive inhibitory peptide (OPIP), or adenovirus‐mediated knockdown of ZDHHC18 expression presents a ...
Sidi Yang, Kun Li, Lihong Liu, Linsen Zeng, Qifeng Deng, Jiacheng Huang, Xiaoran Dong, Xin Wang, Jianwei Liang, Hongchao Liu, Hong Peng, Yuxin Lin, Xiaolu Xie, Yuzhen Ye, Tiefeng Xu, Zhaohuan Wang, Chun‐Mei Li, Deyin Guo   +17 more
wiley   +1 more source

Temporal Regulation of RNA Synthesis of Bovine Coronavirus [PDF]

, 1987
It has been shown with mouse hepatitis virus (MHV) and avian infectious bronchitis virus that all of the subgenomic mRNAs and genomic RNA are synthesized at the same rate throughout the viral replication cycle (Leibowitz et al., 1981; Stern and Kennedy, 1980). The viral genomic RNA gradually accumulates late in infection.
J G, Keck, B G, Hogue, D A, Brian, M M, Lai   +3 more
openaire   +2 more sources

Serum Antibodies to Bovine Coronavirus in Swedish Sheep [PDF]

Acta Veterinaria Scandinavica, 1999
Altogether 218 sheep sera from 40 flocks in different parts of Sweden were screened for antibodies to bovine coronavirus (BCV). Nineteen per cent of the sera were positive and there was a significantly higher frequency (p < 0.05) of at least one positive sample in flocks with more than 100 adult sheep than in smaller flocks.
M, Tråvén, U, Carlsson, A, Lundén, B, Larsson   +3 more
openaire   +2 more sources

Heterogeneity of gene expression of the hemagglutinin-esterase (HE) protein of murine coronaviruses. [PDF]

, 1991
The hemagglutinin-esterase (HE) membrane glycoprotein is present only in some members of the coronavirus family, including some strains of mouse hepatitis virus (MHV). In the JHM strain of MHV, expression of the HE gene is variable and corresponds to the
Banner, LR, Lai, MM, Yokomori, K
core  

Structure and Expression of the Bovine Coronavirus Hemagglutinin Protein [PDF]

, 1990
cDNA clones prepared from genomic RNA of the Mebus strain of bovine Coronavirus (BCV) were sequenced to reveal the hemagglutinin (H) gene of 1,272 bases that predicts a 47,700 mol. wt. apoprotein of 424 amino acids. The H gene mapped on the immediate 5′ side of the peplomer gene.
T E, Kienzle, S, Abraham, B G, Hogue, D A, Brian   +3 more
openaire   +2 more sources

Biosynthesis, structure, and biological activities of envelope protein gp65 of murine coronavirus. [PDF]

, 1989
We have previously shown that gp65 (E3) is a virion structural protein which varies widely in quantity among different strains of mouse hepatitis virus (MHV). In this study, the biosynthetic pathway and possible biological activities of this protein were
La Monica, N, Lai, MM, Makino, S, Shieh, CK, Yokomori, K   +4 more
core  

Purification and electron cryomicroscopy of coronavirus particles. [PDF]

, 2008
Intact, enveloped coronavirus particles vary widely in size and contour, and are thus refractory to study by traditional structural means such as X-ray crystallography. Electron microscopy (EM) overcomes some problems associated with particle variability
Adair, Brian D, Buchmeier, Michael J, Neuman, Benjamin W, Yeager, Mark   +3 more
core   +1 more source