Bovine herpesvirus type 1 as a novel oncolytic virus [PDF]
Oncolytic virotherapy is a promising avenue of cancer gene therapy. Current vectors include human viruses that have been engineered to replicate in tumor cells or nonhuman viruses that are naturally oncotropic and preferentially replicate in tumor cells harboring defects in innate immune pathways such as the type 1 interferon (IFN) pathway.
R, Rodrigues, B, Cuddington, K, Mossman
openaire +2 more sources
Persistent infection with bovine herpesvirus type 1: rabbit model [PDF]
Persistent infection with bovine herpesvirus type 1 (BHV-1) was established in all rabbits after conjunctival inoculation of virus. Spontaneous reactivations of BHV-1 with and without the appearance of recurrent ocular lesions were observed in persistently infected rabbits.
D L, Rock, D E, Reed
openaire +2 more sources
Varicellovirus UL 49.5 proteins differentially affect the function of the transporter associated with antigen processing, TAP [PDF]
Cytotoxic T-lymphocytes play an important role in the protection against viral infections, which they detect through the recognition of virus-derived peptides, presented in the context of MHC class I molecules at the surface of the infected cell.
Bienkowska-Szewczyk, Krystyna +19 more
core +7 more sources
Therapeutic Impact of Caffeic Acid Phenethyl Ester and Acyclovir Combination on Human Gingival Fibroblasts (HGF-1) Infected With Herpes Simplex Type 1 ICP0. [PDF]
ABSTRACT Herpes simplex virus Type 1 (HSV‐1) is a prevalent infectious agent globally, often causing oral infections like gingivostomatitis. The ICP0 protein of HSV‐1 exacerbates infection severity by inhibiting antiviral responses. Our study explored how combinations of CAPE (caffeic acid phenethyl ester) and acyclovir influenced immune responses in ...
Sen M, Celik S.
europepmc +2 more sources
Bovine herpesvirus type 1 in cumulus-oocyte complexes collected from naturally infected cows [PDF]
: The objective of this work was to investigate the presence of bovine herpesvirus type 1 (BoHV-1) in follicular fluid and in cumulus-oocyte complexes (COC) recovered from naturally infected cows but with no clinical signs of the disease.
Andre Penido Oliveira +5 more
doaj +2 more sources
Nonspecific suppressive effect of bovine herpesvirus type 1 on bovine leukocyte functions [PDF]
The effect of bovine herpesvirus type 1 on the specific and nonspecific immune response of calves was examined. Animals with or without prior aerosol exposure to Pasteurella haemolytica serotype A1 were aerosol challenged with 10(8) PFU of virus. Blood and serum samples were taken before and after virus challenge for determining cell-mediated, humoral,
L G, Filion, R L, McGuire, L A, Babiuk
openaire +2 more sources
Genome sequence of canine herpesvirus [PDF]
Canine herpesvirus is a widespread alphaherpesvirus that causes a fatal haemorrhagic disease of neonatal puppies. We have used high-throughput methods to determine the genome sequences of three viral strains (0194, V777 and V1154) isolated in the United ...
Davison, Andrew +5 more
core +7 more sources
Sensitive detection systems for infectious agents in xenotransplantation*
Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley +1 more source
Cette revue présente les infections des ruminants sauvages par cinq herpèsvirus antigéniquement apparentés : le virus de la rhinotrachéite infectieuse bovine (bovine herpesvirus 1), l’herpèsvirus de la chèvre (caprine herpesvirus 2), l’herpèsvirus de ...
Etienne Thiry +2 more
doaj +1 more source
Degenerate PCR method for identification of an antiapoptotic gene in BHV-1 [PDF]
To investigate on the hypothetical presence of an antiapoptotic gene, we utilized the CODEHOP (COnsensus-DEgenerate Hybrid Oligonucleotide Primers) strategy amplifying unknown sequences from a background of genomic (bovine herpesvirus type-1) BHV-1 DNA ...
Ciriolo, MR +9 more
core +1 more source

