Results 241 to 250 of about 454,290 (357)

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

Advanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao, Yaxian Liao, Pengyun Li, Regina Stasser de Gonzalez, Xuankun Chen, Nicholas S. Nieto, Florence M. Brunel, Nick Cox, Joseph Stock, Matthew McHenry, Guangsen Fu, Penghsuan Huang, Wenxin Wu, Deqin Cai, Lingjun Li, Alexander N. Zaykov, Weiping Tang   +16 more
wiley   +1 more source

Effects of Diet and Injection of Bovine Somatotropin on Prepubertal Growth and First-Lactation Milk Yields of Holstein Cows

, 2000
R.P. Radcliff, M.J. VandeHaar, L. T. Chapin, Thomas E. Pilbeam, D.K. Beede, E.P. Stanisiewski, H. A. Tucker   +6 more
openalex   +1 more source

Non-Bovine Milk as Functional Foods with Focus on Their Antioxidant and Anti-Inflammatory Bioactivities. [PDF]

Antioxidants (Basel)
Li Y, Ma Q, Li M, Liu W, Liu Y, Wang M, Wang C, Khan MZ.   +7 more
europepmc   +1 more source

Targeted Mitochondrial ECSIT Overexpression Attenuates MASH by Increasing OTUD3 Expression

Advanced Science, EarlyView.
Mitochondrial ECSIT expression is reduced during MASH pathogenesis. Overexpression of mitochondrial ECSIT mitigates steatohepatitis and maintains hepatic metabolic homeostasis. Mechanistically, ECSIT enhances intramitochondrial OTUD3 expression to stabilize SIRT3 through deubiquitination, thus preserving mitochondrial function and impeding disease ...
Yuqing Jiang, Tingting Tong, Pengxi Shi, Xiaofan Chen, Chenhao Wang, Qingyuan Weng, Sihan Chen, Linli Que, Qi Chen, Yuehua Li, Qiang Zhu, Jiantao Li   +11 more
wiley   +1 more source

A humoral immunoregulatory mechanism of bovine milk immunoglobulin G via Fcγ receptors in mice

, 2007
Hidetaka Ohnuki, Hajime Otani
openalex   +1 more source

Rational designing and synthesizing an antimicrobial peptide from bovine milk casein and evaluating its biological properties. [PDF]

Amino Acids
Pourhosseini SR, Akbari B, Ghods E, Veisi K, Madanchi H.   +4 more
europepmc   +1 more source

Reduced Maintenance DNA Methylation Thresholds Enable Sensitive Reporter Assays for UHRF1 and DNMT1 Inhibition

Advanced Science, EarlyView.
The authors engineer colorectal cancer cells with reduced redundancy of UHRF1 and DNMT1, key DNA methylation maintenance factors, lowering the maintenance threshold and sensitizing cells to inhibition. They develop reporter assays driven by endogenous tumor‐suppressor gene promoters with enhanced sensitivity and dynamic range to demethylating drugs ...
Cuicui Xia, Ying Cui, Jiongliang Wang, Wenjing Bai, Danyang Wang, Yao Chen, Huahui Guo, Liangyi Zong, Bing Qin, Xintong Cai, Jie Wang, Jing Huang, Scott B. Rothbart, Zufeng Guo, Stephen B. Baylin, Xiangqian Kong   +15 more
wiley   +1 more source

Cumulative exposure and dietary risk assessment of phthalates in bottled water and bovine milk samples: A preliminary case study in Tamil Nadu, India

, 2016
Krishna Kumar Selvaraj, Habibunisha Mubarakali, Maniraj Rathinam, Lakshmi Harikumar, Srimurali Sampath, Govindaraj Shanmugam, Babu Rajendran Ramaswamy   +6 more
openalex  

Additional file 1: Table S1. of Dietary supplementation with bovine-derived milk fat globule membrane lipids promotes neuromuscular development in growing rats

, 2017
James Markworth, Brenan R. Durainayagam, Vandré C. Figueiredo, Karen Liu, Jian Guan, Alastair MacGibbon, Bertram Fong, Aaron C. Fanning, Angela Rowan, Paul McJarrow, David Cameron-Smith   +10 more
openalex   +1 more source

Exosome-Derived miR-11987 in Bovine Milk Inhibits Obesity Through Browning of White Fat. [PDF]

Int J Mol Sci
Bae IS, Kim SH.
europepmc   +1 more source