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Anti-BP180-type Mucous Membrane Pemphigoid Immunoglobulin G Shows Heterogeneity of Internalization of BP180/Collagen XVII into Keratinocyte Cytoplasm

Anti-BP180-type Mucous Membrane Pemphigoid Immunoglobulin G Shows Heterogeneity of Internalization of BP180/Collagen XVII into Keratinocyte Cytoplasm
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Hemidesmosomes and their unique transmembrane protein BP180

Microscopy Research and Technique, 1998
Hemidesmosomes are adhesion complexes responsible for linking keratin intermediate filaments of stratified and complex epithelia to components of the extracellular matrix such as collagen fibrils. Over the past several years, it has become clear that there are at least five hemidesmosomal proteins, including HD1/plectin and BP230 as cytoplasmic plaque ...
Y, Hirako, K, Owaribe
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Oral pemphigoid autoantibodies preferentially target BP180 ectodomain

Clinical Immunology, 2007
Mucous membrane pemphigoid (MMP) comprises a heterogenous group of autoimmune subepithelial bullous diseases very frequently having oral involvement. Very few studies have investigated the immunological status of a subset of MMP, termed oral pemphigoid (OP), presenting with exclusive oral lesions.
CALABRESI, V., CARROZZO, M., COZZANI, EMANUELE CLAUDIO, ARDUINO, P., BERTOLUSSO, G., TIRONE, F., PARODI, AURORA, ZAMBRUNO, G., DI ZENZO, G.   +8 more
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Super‐resolution imaging detects BP180 autoantigen in immunoglobulin M pemphigoid

The Journal of Dermatology, 2021
AbstractBullous pemphigoid is generally caused by immunoglobulin (Ig)G autoantibodies against hemidesmosomal BP180 and/or BP230. Recently, the concept of IgM pemphigoid has been proposed. A 23‐year‐old Japanese woman presented with a 4‐month history of severely itchy papules showing subepidermal separations with mild neutrophil infiltration.
Yoko Hirano, Hiroaki Iwata, Masumi Tsujuwaki, Shoko Mai, Yosuke Mai, Keisuke Imafuku, Kentaro Izumi, Hiroshi Koga, Hideyuki Ujiie   +8 more
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Anti-BP180-type mucous membrane pemphigoid immunoglobulin G shows heterogeneity of internalization of BP180/collagen XVII into keratinocyte cytoplasm

Medical Molecular Morphology, 2015
Anti-BP180-type mucous membrane pemphigoid (BP180-MMP) is a rare autoimmune subepidermal blistering disease that targets the C terminus of BP180/collagen XVII. Currently, the pathomechanism of BP180-MMP is not well understood. We reported previously that immunoglobulin G (IgG) from patients with bullous pemphigoid (BP) can induce internalization of ...
Akiko, Imanishi, Hisayoshi, Imanishi, Sho, Hiroyasu, Toshiyuki, Ozawa, Hiroshi, Koga, Norito, Ishii, Yasuo, Kitajima, Takashi, Hashimoto, Daisuke, Tsuruta   +8 more
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IgE autoantibodies against the intracellular domain of BP180

British Journal of Dermatology, 2009
Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease characterized by autoantibodies against the hemidesmosomal proteins BP180 (type XVII collagen) and BP230. BP not only involves IgG-mediated neutrophil activation, leading to blistering, but also IgE-dependent activation of mast cells and basophils. While IgG and IgE autoantibodies
S K, Dresow, C, Sitaru, A, Recke, G J, Oostingh, D, Zillikens, B F, Gibbs   +5 more
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Correlation of clinical severity and ELISA indices for the NC16A domain of BP180 measured using BP180 ELISA kit in bullous pemphigoid

Journal of Dermatological Science, 2005
Titres of circulating autoantibodies detected by indirect immunofluorescence (IIF) have been used for the diagnosis and evaluation of disease activity in bullous pemphigoid (BP). In BP, the major pathogenic epitope is known to be the non-collagenous extracellular domain (NC16A) of the 180-kDa transmembrane hemidesmosomal protein (BPAG2).
Yukiko, Tsuji-Abe, Masashi, Akiyama, Yasuko, Yamanaka, Toshiro, Kikuchi, Kazuko C, Sato-Matsumura, Hiroshi, Shimizu   +5 more
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Paraneoplastic pemphigus with anti-BP180 autoantibodies and Castleman disease

British Journal of Dermatology, 2017
Paraneoplastic pemphigus (PNP) is commonly associated with IgG-autoantibodies against desmoglein 1 and 3, plakins (desmoplakin I and II, envoplakin, periplakin), desmocollins 1-3, BP2301 and α2-macroglobulin-like-1 (A2ML1)2. The major autoantigen of bullous pemphigoid (BP), pemphigoid gestationis and lichen planus pemphigoides (LPP) is the NC16A domain
L. Maier, A. Udvardi, M. Hertl, R. Eming, E. Schmidt, D. Zillikens, B. Volc-Platzer   +6 more
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Anti-BP180-type mucous membrane pemphigoid: report of two cases

Odontology, 2014
We describe two patients with anti-BP180-type mucous membrane pemphigoid (MMP), who were correctly diagnosed and treated in early stages through the cooperation of dentists and dermatologists. Patient 1 was a 74-year-old woman who visited our dental department due to blisters over the oral mucosa and eruptions on the skin.
Mayumi, Wada, Jun, Sato, Masanobu, Shindoh, Hideyuki, Ujiie, Ken, Natsuga, Wataru, Nishie, Hiroshi, Shimizu, Yoshimasa, Kitagawa   +7 more
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Fc‐binding proteins enhance autoantibody‐induced BP180 depletion in pemphigoid

The Journal of Pathology, 2019
Abstract Immunoglobulins (Igs) consist of two antigen‐binding regions (Fab) and one constant region (Fc). Protein A and protein G are bacterial proteins used for the purification of IgG by virtue of their high affinities for the Fc fragment. Rheumatoid factors are autoantibodies against IgG Fc fragments, which are
Hiroaki Iwata, Mayumi Kamaguchi, Hideyuki Ujiie, Inkin Ujiie, Ken Natsuga, Wataru Nishie, Hiroshi Shimizu   +6 more
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