Results 161 to 170 of about 3,264 (192)

Role of the Bullous Pemphigoid Antigen 180 (BP180) in the Assembly of Hemidesmosomes and Cell Adhesion—Reexpression of BP180 in Generalized Atrophic Benign Epidermolysis Bullosa Keratinocytes

Experimental Cell Research, 1998
Bullous pemphigoid antigen 180 (BP180) is a transmembrane component of hemidesmosomes (HD), cell-substrate attachment complexes in stratified and complex epithelia.
Arnoud Sonnenberg, Laurent Gagnoux-Palacios   +1 more
exaly   +5 more sources

BP180 gene delivery in junctional epidermolysis bullosa [PDF]

Gene Therapy, 1999
Epidermolysis bullosa (EB) comprises a family of inherited blistering skin diseases for which current therapy is only palliative. Junctional EB (JEB) involves dissociation of the dermal-epidermal junction and results from mutations in a number of genes that encode vital structural proteins, including BP180 (type XVII collagen/BPAG2).
Matt Marinkovich, Paul Khavari, George J Giudice   +2 more
exaly   +3 more sources

Anti-BP180-type mucous membrane pemphigoid immunoglobulin G shows heterogeneity of internalization of BP180/collagen XVII into keratinocyte cytoplasm

Medical Molecular Morphology, 2015
Anti-BP180-type mucous membrane pemphigoid (BP180-MMP) is a rare autoimmune subepidermal blistering disease that targets the C terminus of BP180/collagen XVII. Currently, the pathomechanism of BP180-MMP is not well understood. We reported previously that immunoglobulin G (IgG) from patients with bullous pemphigoid (BP) can induce internalization of ...
Daisuke Tsuruta, Hisayoshi Imanishi, Hiroshi Koga   +2 more
exaly   +4 more sources

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Hemidesmosomes and their unique transmembrane protein BP180

Microscopy Research and Technique, 1998
Hemidesmosomes are adhesion complexes responsible for linking keratin intermediate filaments of stratified and complex epithelia to components of the extracellular matrix such as collagen fibrils. Over the past several years, it has become clear that there are at least five hemidesmosomal proteins, including HD1/plectin and BP230 as cytoplasmic plaque ...
Y, Hirako, K, Owaribe
openaire   +2 more sources

Detection of a natural antibody targeting the shed ectodomain of BP180 in mice

Journal of Dermatological Science, 2023
Pemphigoid diseases are characterized by subepidermal blister formation accompanied by autoantibodies targeting skin component molecules, such as BP180. It is suggested that an epitope-phenotype correlation exists among autoantibodies recognizing BP180. However, it is unclear which regions of BP180 are likely targets for autoantibodies.To elucidate the
Yosuke, Mai, Kentaro, Izumi, Shoko, Mai, Wataru, Nishie, Hideyuki, Ujiie   +4 more
openaire   +2 more sources

Correlation of clinical severity and ELISA indices for the NC16A domain of BP180 measured using BP180 ELISA kit in bullous pemphigoid

Journal of Dermatological Science, 2005
Titres of circulating autoantibodies detected by indirect immunofluorescence (IIF) have been used for the diagnosis and evaluation of disease activity in bullous pemphigoid (BP). In BP, the major pathogenic epitope is known to be the non-collagenous extracellular domain (NC16A) of the 180-kDa transmembrane hemidesmosomal protein (BPAG2).
Yukiko, Tsuji-Abe, Masashi, Akiyama, Yasuko, Yamanaka, Toshiro, Kikuchi, Kazuko C, Sato-Matsumura, Hiroshi, Shimizu   +5 more
openaire   +2 more sources

Reactivity against the BP180 ectodomain in patients with bullous pemphigoid, mucous membrane pemphigoid, multiple sclerosis and Parkinson disease [PDF]

Experimental Dermatology
The 16th non-collagenous domain (NC16A) of BP180 is the main antigenic target of autoantibodies in bullous pemphigoid (BP) and mucous membrane pemphigoid (MMP). Commercially available assays detect serum autoantibodies against NC16A in the majority of BP
Christoph M Hammers, Stephanie Goletz, Enno Schmidt   +2 more
exaly   +2 more sources

Paraneoplastic pemphigus with anti-BP180 autoantibodies and Castleman disease

British Journal of Dermatology, 2017
Paraneoplastic pemphigus (PNP) is commonly associated with IgG-autoantibodies against desmoglein 1 and 3, plakins (desmoplakin I and II, envoplakin, periplakin), desmocollins 1-3, BP2301 and α2-macroglobulin-like-1 (A2ML1)2. The major autoantigen of bullous pemphigoid (BP), pemphigoid gestationis and lichen planus pemphigoides (LPP) is the NC16A domain
L. Maier, A. Udvardi, M. Hertl, R. Eming, E. Schmidt, D. Zillikens, B. Volc-Platzer   +6 more
openaire   +1 more source

A case of neonatal pemphigus vulgaris with co‐existing BP180 autoantibodies

Pediatric Dermatology, 2019
AbstractA male neonate was born with blisters on the trunk to a 37‐year‐old primigravid woman with a past medical history of recurrent, painful, topical steroid‐responsive oral blisters. The diagnosis of neonatal pemphigus was made after the neonate and mother were found to have elevated desmoglein 3 (Dsg3) antibodies in conjunction with ...
Justine Fenner, Michelle S. Min, Stephanie Liu, Nanette Silverberg   +3 more
openaire   +2 more sources

Autoreactivity to BP180 Neoepitopes in Patients With Pemphigoid Gestationis

JAMA Dermatology, 2022
Schauer, Franziska, Mai, Shoko, Hofmann, Silke, Mai, Yosuke, Izumi, Kentaro, Kern, Johannes Steffen, Kiritsi, Dimitra   +6 more
openaire   +3 more sources