Results 1 to 10 of about 25,687 (118)

DNAJB9 in Fibrillary Glomerulonephritis: Diagnostic Biomarker, Putative Autoantigen, or Disease-Associated Scaffold? A Case-Based Narrative Review [PDF]

Life
Fibrillary glomerulonephritis (FGN) is an uncommon glomerular deposition disease characterized by randomly oriented, nonbranching fibrils that are usually Congo-red-negative and larger than amyloid fibrils on electron microscopy.
Larrisa Lebedev, Mahmud Mansur, Mustafa Seh, Elena Rotshild, Ornit Itzhaki, Alexander Wechsler, Anna Tobar, Nomy Levin Iaina   +7 more
doaj   +2 more sources

Multiplexed Detection of Membranous Nephropathy Antigens by Multi-Reaction Monitoring Mass Spectrometry [PDF]

Kidney International Reports
Background: Membranous nephropathy (MN) is a leading cause of nephrotic syndrome, driven by an immune response against a target autoantigen. To date, over 30 target antigens have been described in MN, creating the need for multiplex approaches.
Aaron J. Storey, Tiffany N. Caza, Samar I. Hassen, Owen W. Stephens, Lindsey Vanhouten, Rick Edmondson, Daniel Kenan, Christopher P. Larsen   +7 more
doaj   +2 more sources

Immune Dysregulation in IgG4-Related Disease

Frontiers in Immunology, 2021
Immunoglobin G4-related disease (IgG4-RD) is one of the newly discovered autoimmune diseases characterized by elevated serum IgG4 concentrations and multi-organ fibrosis.
Jiachen Liu, Wei Yin, Lisa S. Westerberg, Pamela Lee, Quan Gong, Yan Chen, Lingli Dong, Chaohong Liu   +7 more
doaj   +1 more source

Autoantibody discovery across monogenic, acquired, and COVID-19-associated autoimmunity with scalable PhIP-seq

eLife, 2022
Phage immunoprecipitation sequencing (PhIP-seq) allows for unbiased, proteome-wide autoantibody discovery across a variety of disease settings, with identification of disease-specific autoantigens providing new insight into previously poorly understood ...
Sara E Vazquez, Sabrina A Mann, Aaron Bodansky, Andrew F Kung, Zoe Quandt, Elise MN Ferré, Nils Landegren, Daniel Eriksson, Paul Bastard, Shen-Ying Zhang, Jamin Liu, Anthea Mitchell, Irina Proekt, David Yu, Caleigh Mandel-Brehm, Chung-Yu Wang, Brenda Miao, Gavin Sowa, Kelsey Zorn, Alice Y Chan, Veronica M Tagi, Chisato Shimizu, Adriana Tremoulet, Kara Lynch, Michael R Wilson, Olle Kämpe, Kerry Dobbs, Ottavia M Delmonte, Rosa Bacchetta, Luigi D Notarangelo, Jane C Burns, Jean-Laurent Casanova, Michail S Lionakis, Troy R Torgerson, Mark S Anderson, Joseph L DeRisi   +35 more
doaj   +1 more source

Autoantibodies Targeting Intracellular and Extracellular Proteins in Autoimmunity

Frontiers in Immunology, 2021
Detecting autoantibodies provides foundational information for the diagnosis of most autoimmune diseases. An important pathophysiological distinction is whether autoantibodies are directed against extracellular or intracellular proteins.
Peter D. Burbelo, Michael J. Iadarola, Jason M. Keller, Blake M. Warner   +3 more
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Alphavirus Replicon Particle Vaccine Breaks B Cell Tolerance and Rapidly Induces IgG to Murine Hematolymphoid Tumor Associated Antigens

Frontiers in Immunology, 2022
De novo immune responses to myeloid and other blood-borne tumors are notably limited and ineffective, making our ability to promote immune responses with vaccines a major challenge.
Hsuan Su, Kazuhiro Imai, Kazuhiro Imai, Wei Jia, Zhiguo Li, Zhiguo Li, Rachel A. DiCioccio, Jonathan S. Serody, Jonathan S. Serody, Jonathan S. Serody, Jonathan C. Poe, Benny J. Chen, Benny J. Chen, Phuong L. Doan, Phuong L. Doan, Stefanie Sarantopoulos, Stefanie Sarantopoulos, Stefanie Sarantopoulos   +17 more
doaj   +1 more source

Mapping Autoantibodies in Children With Acute Rheumatic Fever

Frontiers in Immunology, 2021
BackgroundAcute rheumatic fever (ARF) is a serious sequela of Group A Streptococcus (GAS) infection associated with significant global mortality. Pathogenesis remains poorly understood, with the current prevailing hypothesis based on molecular mimicry ...
Reuben McGregor, Reuben McGregor, Mei Lin Tay, Lauren H. Carlton, Paulina Hanson-Manful, Jeremy M. Raynes, Wasan O. Forsyth, Diane T. Brewster, Martin J. Middleditch, Julie Bennett, William John Martin, Nigel Wilson, Polly Atatoa Carr, Michael G. Baker, Michael G. Baker, Nicole J. Moreland, Nicole J. Moreland   +16 more
doaj   +1 more source

Regulatory T cells inhibit autoantigen-specific CD4+ T cell responses in lupus-prone NZB/W F1 mice

Frontiers in Immunology, 2023
IntroductionProgressive loss of regulatory T cell (Treg)-mediated control over autoreactive effector T cells contributes to the development of systemic lupus erythematosus (SLE).
Stefan Rosenberger, Stefan Rosenberger, Reinmar Undeutsch, Reinmar Undeutsch, Reza Akbarzadeh, Justus Ohmes, Philipp Enghard, Philipp Enghard, Gabriela Riemekasten, Gabriela Riemekasten, Jens Y. Humrich, Jens Y. Humrich   +11 more
doaj   +1 more source

Enhanced Expression of Autoantigens During SARS-CoV-2 Viral Infection

Frontiers in Immunology, 2021
Immune homeostasis is disturbed during severe viral infections, which can lead to loss of tolerance to self-peptides and result in short- or long-term autoimmunity.
Narjes Saheb Sharif-Askari, Fatemeh Saheb Sharif-Askari, Samrein B. M. Ahmed, Samrein B. M. Ahmed, Suad Hannawi, Rifat Hamoudi, Rifat Hamoudi, Rifat Hamoudi, Qutayba Hamid, Qutayba Hamid, Qutayba Hamid, Rabih Halwani, Rabih Halwani, Rabih Halwani   +13 more
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Case Report: Bullous Pemphigoid Associated With Morphea and Lichen Sclerosus: Coincidental Diseases or Pathogenetic Association?

Frontiers in Immunology, 2022
Bullous pemphigoid (BP) represents the most common autoimmune bullous disease and is characterized by IgG autoantibodies targeting collagen XVII (BP180). BP has reportedly been occurred in association with other inflammatory skin diseases.
Roberto Maglie, Maria Efenesia Baffa, Francesca Montefusco, Carlo Pipitò, Stefano Senatore, Marco Capassoni, Marco Capassoni, Vincenza Maio, Marco Matucci Cerinic, Marco Matucci Cerinic, Emiliano Antiga, Serena Guiducci, Serena Guiducci   +12 more
doaj   +1 more source