Results 1 to 10 of about 24,474 (120)

Immune Dysregulation in IgG4-Related Disease

Frontiers in Immunology, 2021
Immunoglobin G4-related disease (IgG4-RD) is one of the newly discovered autoimmune diseases characterized by elevated serum IgG4 concentrations and multi-organ fibrosis.
Jiachen Liu, Wei Yin, Lisa S. Westerberg, Pamela Lee, Quan Gong, Yan Chen, Lingli Dong, Chaohong Liu   +7 more
doaj   +1 more source

Autoantibody discovery across monogenic, acquired, and COVID-19-associated autoimmunity with scalable PhIP-seq

eLife, 2022
Phage immunoprecipitation sequencing (PhIP-seq) allows for unbiased, proteome-wide autoantibody discovery across a variety of disease settings, with identification of disease-specific autoantigens providing new insight into previously poorly understood ...
Sara E Vazquez, Sabrina A Mann, Aaron Bodansky, Andrew F Kung, Zoe Quandt, Elise MN Ferré, Nils Landegren, Daniel Eriksson, Paul Bastard, Shen-Ying Zhang, Jamin Liu, Anthea Mitchell, Irina Proekt, David Yu, Caleigh Mandel-Brehm, Chung-Yu Wang, Brenda Miao, Gavin Sowa, Kelsey Zorn, Alice Y Chan, Veronica M Tagi, Chisato Shimizu, Adriana Tremoulet, Kara Lynch, Michael R Wilson, Olle Kämpe, Kerry Dobbs, Ottavia M Delmonte, Rosa Bacchetta, Luigi D Notarangelo, Jane C Burns, Jean-Laurent Casanova, Michail S Lionakis, Troy R Torgerson, Mark S Anderson, Joseph L DeRisi   +35 more
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Autoantibodies Targeting Intracellular and Extracellular Proteins in Autoimmunity

Frontiers in Immunology, 2021
Detecting autoantibodies provides foundational information for the diagnosis of most autoimmune diseases. An important pathophysiological distinction is whether autoantibodies are directed against extracellular or intracellular proteins.
Peter D. Burbelo, Michael J. Iadarola, Jason M. Keller, Blake M. Warner   +3 more
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Alphavirus Replicon Particle Vaccine Breaks B Cell Tolerance and Rapidly Induces IgG to Murine Hematolymphoid Tumor Associated Antigens

Frontiers in Immunology, 2022
De novo immune responses to myeloid and other blood-borne tumors are notably limited and ineffective, making our ability to promote immune responses with vaccines a major challenge.
Hsuan Su, Kazuhiro Imai, Kazuhiro Imai, Wei Jia, Zhiguo Li, Zhiguo Li, Rachel A. DiCioccio, Jonathan S. Serody, Jonathan S. Serody, Jonathan S. Serody, Jonathan C. Poe, Benny J. Chen, Benny J. Chen, Phuong L. Doan, Phuong L. Doan, Stefanie Sarantopoulos, Stefanie Sarantopoulos, Stefanie Sarantopoulos   +17 more
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Mapping Autoantibodies in Children With Acute Rheumatic Fever

Frontiers in Immunology, 2021
BackgroundAcute rheumatic fever (ARF) is a serious sequela of Group A Streptococcus (GAS) infection associated with significant global mortality. Pathogenesis remains poorly understood, with the current prevailing hypothesis based on molecular mimicry ...
Reuben McGregor, Reuben McGregor, Mei Lin Tay, Lauren H. Carlton, Paulina Hanson-Manful, Jeremy M. Raynes, Wasan O. Forsyth, Diane T. Brewster, Martin J. Middleditch, Julie Bennett, William John Martin, Nigel Wilson, Polly Atatoa Carr, Michael G. Baker, Michael G. Baker, Nicole J. Moreland, Nicole J. Moreland   +16 more
doaj   +1 more source

Regulatory T cells inhibit autoantigen-specific CD4+ T cell responses in lupus-prone NZB/W F1 mice

Frontiers in Immunology, 2023
IntroductionProgressive loss of regulatory T cell (Treg)-mediated control over autoreactive effector T cells contributes to the development of systemic lupus erythematosus (SLE).
Stefan Rosenberger, Stefan Rosenberger, Reinmar Undeutsch, Reinmar Undeutsch, Reza Akbarzadeh, Justus Ohmes, Philipp Enghard, Philipp Enghard, Gabriela Riemekasten, Gabriela Riemekasten, Jens Y. Humrich, Jens Y. Humrich   +11 more
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Low T-cell reactivity to TDP-43 peptides in ALS

Frontiers in Immunology, 2023
BackgroundDysregulation of the immune system in amyotrophic lateral sclerosis (ALS) includes changes in T-cells composition and infiltration of T cells in the brain and spinal cord.
Swetha Ramachandran, Veselin Grozdanov, Bianca Leins, Katharina Kandler, Simon Witzel, Medhanie Mulaw, Albert C. Ludolph, Albert C. Ludolph, Jochen H. Weishaupt, Karin M. Danzer, Karin M. Danzer   +10 more
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Autoantigens in the trabecular meshwork and glaucoma‐specific alterations in the natural autoantibody repertoire

Clinical & Translational Immunology, 2020
Objectives Primary open‐angle glaucoma (POAG) is a neurodegenerative disorder leading to a gradual vision loss caused by progressive damage to the optic nerve. Immunological processes are proposed to be involved in POAG pathogenesis.
Vanessa M Beutgen, Carsten Schmelter, Norbert Pfeiffer, Franz H Grus   +3 more
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C-Reactive Protein: Friend or Foe? Phylogeny From Heavy Metals to Modified Lipoproteins and SARS-CoV-2

Frontiers in Cardiovascular Medicine, 2022
Animal C-reactive protein (CRP) has a widespread existence throughout phylogeny implying that these proteins have essential functions mandatory to be preserved.
Michael Torzewski
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Autoantibody Repertoire in APECED Patients Targets Two Distinct Subgroups of Proteins

Frontiers in Immunology, 2017
High titer autoantibodies produced by B lymphocytes are clinically important features of many common autoimmune diseases. APECED patients with deficient autoimmune regulator (AIRE) gene collectively display a broad repertoire of high titer autoantibodies,
Dmytro Fishman, Dmytro Fishman, Kai Kisand, Christina Hertel, Mike Rothe, Anu Remm, Maire Pihlap, Priit Adler, Priit Adler, Jaak Vilo, Jaak Vilo, Aleksandr Peet, Antonella Meloni, Antonella Meloni, Katarina Trebusak Podkrajsek, Tadej Battelino, Øyvind Bruserud, Anette S. B. Wolff, Eystein S. Husebye, Nicolas Kluger, Kai Krohn, Annamari Ranki, Hedi Peterson, Hedi Peterson, Adrian Hayday, Pärt Peterson   +25 more
doaj   +1 more source