Results 21 to 30 of about 32,508 (252)

Human monoclonal islet specific autoantibodies share features of islet cell and 64 kDa antibodies [PDF]

, 1993
The first human monoclonal islet cell antibodies of the IgG class (MICA 1-6) obtained from an individual with Type 1 (insulin-dependent) diabetes mellitus were cytoplasmic islet cell antibodies selected by the indirect immunofluorescence test on pancreas
Brandt, M., Seißler, Jochen, Jungfer, Herbert, Eiermann, Thomas H., Wolfahrt, S., Endl, Josef, Scherbaum, Werner A., Richter, Wiltrud   +7 more
core   +1 more source

Sex-Specific B Cell and Anti-Myelin Autoantibody Response After Peripheral Nerve Injury

Frontiers in Cellular Neuroscience, 2022
Immunotherapy holds promise as a non-addictive treatment of refractory chronic pain states. Increasingly, sex is recognized to impact immune regulation of pain states, including mechanical allodynia (pain from non-painful stimulation) that follows ...
Hee Jong Lee, Hee Jong Lee, Hee Jong Lee, Albert G. Remacle, Swathi K. Hullugundi, Swathi K. Hullugundi, Jennifer Dolkas, Jennifer Dolkas, Jake B. Leung, Andrei V. Chernov, Tony L. Yaksh, Alex Y. Strongin, Veronica I. Shubayev, Veronica I. Shubayev   +13 more
doaj   +1 more source

Conformational stability and domain-specific structural features of tumor autoantigens regulate autoantibody epitope propensity. [PDF]

Protein Sci
Abstract Autoantibodies against tumor‐associated autoantigens are clinically valuable biomarkers for cancer diagnosis; however, the structural determinants governing epitope selectivity remain unknown. Here, we investigated whether the intrinsic conformational stability of target autoantigens regulates the epitope propensity of tumor‐associated ...
Miyamoto A, Yamamoto R, Sakaguchi R, Kutsuma R, Mori T, Masui M, Honjo T, Futami M, Morii M, Watanabe H, Kuribayashi T, Ohashi K, Kiura K, Futami J.   +13 more
europepmc   +2 more sources

Inhibition of STAT3 Signaling Reduces IgA1 Autoantigen Production in IgA Nephropathy

Kidney International Reports, 2017
IgA nephropathy is a chronic renal disease characterized by mesangial immunodeposits that contain autoantigen, which is aberrantly glycosylated IgA1 with some hinge-region O-glycans deficient in galactose.
Koshi Yamada, Zhi-Qiang Huang, Milan Raska, Colin Reily, Joshua C. Anderson, Hitoshi Suzuki, Hiroyuki Ueda, Zina Moldoveanu, Krzysztof Kiryluk, Yusuke Suzuki, Robert J. Wyatt, Yasuhiko Tomino, Ali G. Gharavi, Amy Weinmann, Bruce A. Julian, Christopher D. Willey, Jan Novak   +16 more
doaj   +1 more source

Type XVII collagen: Relevance of distinct epitopes, complement-independent effects, and association with neurological disorders in pemphigoid disorders

Frontiers in Immunology, 2022
Pemphigoid diseases (PD) are autoimmune skin blistering diseases characterized by autoantibodies directed against proteins of the cutaneous basement membrane zone (BMZ).
Bianca Opelka, Enno Schmidt, Enno Schmidt, Stephanie Goletz   +3 more
doaj   +1 more source

Molecular characteristics of the Goodpasture autoantigen [PDF]

, 1993
Molecular characteristics of the Goodpasture autoantigen. Goodpasture syndrome is an autoimmune disease causing rapidly progressive glomerulonephritis and pulmonary hemorrhage.
Kalluri, Raghuram, Reeders, Stephen T., Hudson, Billy G., Noelken, Milton E., Mariyama, Mariko, Gunwar, Sripad   +5 more
core   +1 more source

Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection [PDF]

, 2008
Autoimmune liver diseases, such as autoimmune hepatitis (AIH) and primary biliary cirrhosis, often have severe consequences for the patient. Because of a lack of appropriate animal models, not much is known about their potential viral etiology. Infection
Hintereder, Gudrun, Gudrun Hintereder, Michael P. Manns, Christen, Urs, Herrath, Matthias G. von, Holdener, Martin, Monika Bayer, Johnson, Eric F., Urs Christen, Rodrigo, Evelyn, Frank J. Gonzalez, Pfeilschifter, Josef (Prof. Dr.), Eric F. Johnson, Evelyn Rodrigo, Gonzalez, Frank J., Martin Holdener, Edith Hintermann, Hintermann, Edith, Matthias von G. Herrath, Josef Pfeilschifter, Rhode, Antje, Bayer, Monika, Manns, Michael P., Antje Rhode   +23 more
core   +1 more source

AAgAtlas 1.0: a human autoantigen database [PDF]

, 2016
: Autoantibodies refer to antibodies that target self-antigens, which can play pivotal roles in maintaining homeostasis, distinguishing normal from tumor tissue and trigger autoimmune diseases.

core   +1 more source

Cat# 7011, Isletest™ - islet cell autoantigen (IAA) ELISA

, 2021
Cat# 7011, Isletest™ - islet cell autoantigen (IAA ...
Yueshu Wang (11657593)
core   +1 more source

Reduced Competitiveness of Autoantigen-Engaged B Cells due to Increased Dependence on BAFF [PDF]

, 2004
Peripheral autoantigen binding B cells are poorly competitive with naive B cells for survival and undergo rapid cell death. However, in monoclonal Ig-transgenic mice lacking competitor B cells, autoantigen binding B cells can survive for extended periods.
Ying Xu, Robin Lesley, Jason G Cyster, Shu, Hong-Bing, Cyster, Jason G, Hong-Bing Shu, Donna M Hess, Kalled, Susan L, Susan L Kalled, Schwab, Susan R, Hess, Donna M, Lesley, Robin, Xu, Ying, Susan R Schwab   +13 more
core   +1 more source