Results 11 to 20 of about 32,508 (252)
Retinal glycoprotein enrichment by concanavalin a enabled identification of novel membrane autoantigen synaptotagmin-1 in equine recurrent uveitis. [PDF]
PLoS ONE, 2012 Complete knowledge of autoantigen spectra is crucial for understanding pathomechanisms of autoimmune diseases like equine recurrent uveitis (ERU), a spontaneous model for human autoimmune uveitis. While several ERU autoantigens were identified previously,
Margarete E Swadzba +4 more
doaj +3 more sources
Immunogenicity of autoantigens [PDF]
BMC Genomics, 2011 Autoantibodies against self-antigens have been associated not only with autoimmune diseases, but also with cancer and are even found in healthy individuals. The mechanism causing the autoantibody response remains elusive for the majority of the immunogenic antigens. To deepen the understanding of autoantibody responses, we ask whether natural-occurring,
Keller Andreas +7 more
openaire +3 more sources
TCR-like antibodies targeting autoantigen-mhc complexes: a mini-review [PDF]
, 2022 T cell receptors (TCRs) recognize peptide antigens bound to major histocompatibility complex (MHC) molecules (p/MHC) that are expressed on cell surfaces; while B cell-derived antibodies (Abs) recognize soluble or cell surface native antigens of various ...
Ying Li, Wei Jiang, Elizabeth D. Mellins
core +1 more source
Studies on autoantigens in rheumatoid arthritis [PDF]
, 2003 This thesis describes the use of phage display for the isolation of autoantigens in rheumatoid arthritis. The potential of the technology is demonstrated by the isolation of an autoantigen, eukaryotic translation elongation factor 1a1 (eEF 1 (x 1) from a
Mewar, Devesh
core +6 more sources
Clinical & Translational Immunology, 2020 Objectives Primary open‐angle glaucoma (POAG) is a neurodegenerative disorder leading to a gradual vision loss caused by progressive damage to the optic nerve. Immunological processes are proposed to be involved in POAG pathogenesis.
Vanessa M Beutgen +3 more
doaj +1 more source
Frontiers in Immunology, 2022 A method to stimulate T lymphocytes with a broad range of brain antigens would facilitate identification of the autoantigens for multiple sclerosis and enable definition of the pathogenic mechanisms important for multiple sclerosis.
Assaf Gottlieb +2 more
doaj +1 more source
Biomedicines, 2021 Islet autoantibodies are the primary biomarkers used to predict type 1 diabetes (T1D) disease risk. They signal immune tolerance breach by islet autoantigen-specific B lymphocytes.
Jamie L. Felton +2 more
doaj +1 more source
Autoantibody Repertoire in APECED Patients Targets Two Distinct Subgroups of Proteins
Frontiers in Immunology, 2017 High titer autoantibodies produced by B lymphocytes are clinically important features of many common autoimmune diseases. APECED patients with deficient autoimmune regulator (AIRE) gene collectively display a broad repertoire of high titer autoantibodies,
Dmytro Fishman +25 more
doaj +1 more source
Diverse Roles of NETosis in the Pathogenesis of Lupus
Frontiers in Immunology, 2022 NETosis is a form of neutrophil cell death during which extracellular fibrillary structures composed of cytosolic and granule proteins assembled on scaffolds of decondensed chromatin, called neutrophil extracellular traps (NETs), are released.
Meiying Wang +8 more
doaj +1 more source
Rat models of autoimmune uveitis [PDF]
, 2008 Experimental autoimmune uveitis ( EAU) in Lewis rats is a well-established model for human uveitis. During the last years we used this model to demonstrate extraocular induction of uveitis by antigenic mimicry of environmental antigens with retinal ...
Wildner, Gerhild +2 more
core +1 more source