Results 11 to 20 of about 29,540 (247)

Immunogenicity of autoantigens [PDF]

BMC Genomics, 2011
Autoantibodies against self-antigens have been associated not only with autoimmune diseases, but also with cancer and are even found in healthy individuals. The mechanism causing the autoantibody response remains elusive for the majority of the immunogenic antigens. To deepen the understanding of autoantibody responses, we ask whether natural-occurring,
Keller Andreas, Hoffmann Jana, Harz Christian, Leidinger Petra, Ludwig Nicole, Backes Christina, Meese Eckart, Lenhof Hans-Peter   +7 more
openaire   +3 more sources

TCR-like antibodies targeting autoantigen-mhc complexes: a mini-review [PDF]

, 2022
T cell receptors (TCRs) recognize peptide antigens bound to major histocompatibility complex (MHC) molecules (p/MHC) that are expressed on cell surfaces; while B cell-derived antibodies (Abs) recognize soluble or cell surface native antigens of various ...
Ying Li, Wei Jiang, Elizabeth D. Mellins
core   +1 more source

Retinal glycoprotein enrichment by concanavalin a enabled identification of novel membrane autoantigen synaptotagmin-1 in equine recurrent uveitis. [PDF]

, 2012
Complete knowledge of autoantigen spectra is crucial for understanding pathomechanisms of autoimmune diseases like equine recurrent uveitis (ERU), a spontaneous model for human autoimmune uveitis. While several ERU autoantigens were identified previously,
Cornelia A. Deeg, Amann, B., Naim, Hassan Y., Amann, Barbara, Hauck Stefanie M., Barbara Amann, Hassan Y. Naim, Swadzba Margarete E., Naim, H.Y., Naim Hassan Y., Hauck, S.M., Cornelia A Deeg, Swadzba, Margarete E., Margarete E. Swadzba, Deeg Cornelia A., Amann Barbara, Stefanie M Hauck, Stefanie M. Hauck, Hassan Y Naim, Deeg, Cornelia A., Hauck, Stefanie M., Margarete E Swadzba, Deeg, C.A., Swadzba, M.E.   +23 more
core   +1 more source

Rat models of autoimmune uveitis [PDF]

, 2008
Experimental autoimmune uveitis ( EAU) in Lewis rats is a well-established model for human uveitis. During the last years we used this model to demonstrate extraocular induction of uveitis by antigenic mimicry of environmental antigens with retinal ...
Wildner, Gerhild, Thurau, Stephan R., Diedrichs-Moehring, Maria   +2 more
core   +1 more source

Interferon and autoantigens: intersection in autoimmunity

Frontiers in Medicine, 2023
Interferon (IFN) is a key component of the innate immune response. For reasons that remain incompletely understood, the IFN system is upregulated in several rheumatic diseases, particularly those that feature autoantibody production, such as SLE, Sjögren’
Brendan Antiochos, Livia Casciola-Rosen
doaj   +1 more source

Human monoclonal islet specific autoantibodies share features of islet cell and 64 kDa antibodies [PDF]

, 1993
The first human monoclonal islet cell antibodies of the IgG class (MICA 1-6) obtained from an individual with Type 1 (insulin-dependent) diabetes mellitus were cytoplasmic islet cell antibodies selected by the indirect immunofluorescence test on pancreas
Brandt, M., Seißler, Jochen, Jungfer, Herbert, Eiermann, Thomas H., Wolfahrt, S., Endl, Josef, Scherbaum, Werner A., Richter, Wiltrud   +7 more
core   +1 more source

High-Throughput Detection of Autoantigen-Specific B Cells Among Distinct Functional Subsets in Autoimmune Donors

Frontiers in Immunology, 2021
Antigen-specific B cells (ASBCs) can drive autoimmune disease by presenting autoantigen to cognate T cells to drive their activation, proliferation, and effector cell differentiation and/or by differentiating into autoantibody-secreting cells ...
Bryan A. Joosse, James H. Jackson, James H. Jackson, Alberto Cisneros, Austin B. Santhin, Scott A. Smith, Scott A. Smith, Scott A. Smith, Daniel J. Moore, Daniel J. Moore, Daniel J. Moore, Leslie J. Crofford, Leslie J. Crofford, Leslie J. Crofford, Erin M. Wilfong, Erin M. Wilfong, Rachel H. Bonami, Rachel H. Bonami, Rachel H. Bonami   +18 more
doaj   +1 more source

Induction of antigen-specific Treg cells in treating autoimmune uveitis via bystander suppressive pathways without compromising anti-tumor immunity

EBioMedicine, 2021
: Background: Induction of autoantigen-specific Treg cells that suppress tissue-specific autoimmunity without compromising beneficial immune responses is the holy-grail for immunotherapy to autoimmune diseases.
Zilin Chen, Tian Zhang, Hio Tong Kam, Dijie Qiao, Wenwen Jin, Yajie Zhong, Minyi Zhou, Hongyan Zhou, Wai Po Chong, Wanjun Chen, Jun Chen   +10 more
doaj   +1 more source

How Epstein-Barr Virus Drives Multiple Sclerosis: New Mechanisms and Therapeutic Lessons. [PDF]

MedComm (2020)
MedComm, Volume 7, Issue 7, July 2026.
Liu D, Fan W, Jiao P.
europepmc   +2 more sources

Inhibition of STAT3 Signaling Reduces IgA1 Autoantigen Production in IgA Nephropathy

Kidney International Reports, 2017
IgA nephropathy is a chronic renal disease characterized by mesangial immunodeposits that contain autoantigen, which is aberrantly glycosylated IgA1 with some hinge-region O-glycans deficient in galactose.
Koshi Yamada, Zhi-Qiang Huang, Milan Raska, Colin Reily, Joshua C. Anderson, Hitoshi Suzuki, Hiroyuki Ueda, Zina Moldoveanu, Krzysztof Kiryluk, Yusuke Suzuki, Robert J. Wyatt, Yasuhiko Tomino, Ali G. Gharavi, Amy Weinmann, Bruce A. Julian, Christopher D. Willey, Jan Novak   +16 more
doaj   +1 more source