Results 31 to 40 of about 29,540 (247)

Diverse Roles of NETosis in the Pathogenesis of Lupus

Frontiers in Immunology, 2022
NETosis is a form of neutrophil cell death during which extracellular fibrillary structures composed of cytosolic and granule proteins assembled on scaffolds of decondensed chromatin, called neutrophil extracellular traps (NETs), are released.
Meiying Wang, Meiying Wang, Tatsuya Ishikawa, Yupeng Lai, Dhiraj Nallapothula, Ram Raj Singh, Ram Raj Singh, Ram Raj Singh, Ram Raj Singh   +8 more
doaj   +1 more source

Remote Activation of a Latent Epitope in an Autoantigen Decoded With Simulated B-Factors

Frontiers in Immunology, 2019
Mutants of a catalytically inactive variant of Proteinase 3 (PR3)—iPR3-Val103 possessing a Ser195Ala mutation relative to wild-type PR3-Val103—offer insights into how autoantigen PR3 interacts with antineutrophil cytoplasmic antibodies (ANCAs) in ...
Yuan-Ping Pang, Marta Casal Moura, Gwen E. Thompson, Darlene R. Nelson, Amber M. Hummel, Dieter E. Jenne, Daniel Emerling, Wayne Volkmuth, William H. Robinson, Ulrich Specks   +9 more
doaj   +1 more source

Effects of Alemtuzumab on (Auto)antigen-Specific Immune Responses

Frontiers in Immunology, 2020
Alemtuzumab (anti-CD52 mAb) leads to a long-lasting disease activity suppression in patients with relapsing forms of multiple sclerosis (MS). In this study, we examined the change of the immune cell repertoire and the cellular reactivity after treatment ...
Clara Hilger, Christine Riedhammer, Evelyn Orsó, Robert Weissert   +3 more
doaj   +1 more source

Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice [PDF]

, 2015
Background & AimsIt is well-known that the liver can induce immune tolerance, yet this knowledge could, thus far, not be translated into effective treatments for autoimmune diseases. We have previously shown that liver sinusoidal endothelial cells (LSECs)
Reimer, Rudolph, Huber, Samuel, Freund, Barbara, Salmen, Sunhild C., Schramm, Christoph, Lüth, Stefan, Korn, Thomas, Schwinge, Dorothee, Christoph Schramm, Harald Ittrich, Samuel Huber, Waurisch, Christian, Johannes Herkel, Wraith, David C, Rudolph Reimer, Heine, Markus, Heeren, Joerg, Lohse, Ansgar W, Christian Waurisch, Wraith, David C., Alexander Eychmüller, Eychmüller, Alexander, Bruns, Oliver T, David C. Wraith, Salmen, Sunhild C, Ittrich, Harald, Bruns, Oliver T., Stefan Lüth, Lohse, Ansgar W., Dorothee Schwinge, Joerg Heeren, Weller, Horst, Peter Nielsen, Thomas Korn, Markus Heine, Carambia, Antonella, Herkel, Johannes, Antonella Carambia, Sunhild C. Salmen, Horst Weller, Ansgar W. Lohse, Barbara Freund, Oliver T. Bruns, Nielsen, Peter   +43 more
core   +2 more sources

Sex-Specific B Cell and Anti-Myelin Autoantibody Response After Peripheral Nerve Injury

Frontiers in Cellular Neuroscience, 2022
Immunotherapy holds promise as a non-addictive treatment of refractory chronic pain states. Increasingly, sex is recognized to impact immune regulation of pain states, including mechanical allodynia (pain from non-painful stimulation) that follows ...
Hee Jong Lee, Hee Jong Lee, Hee Jong Lee, Albert G. Remacle, Swathi K. Hullugundi, Swathi K. Hullugundi, Jennifer Dolkas, Jennifer Dolkas, Jake B. Leung, Andrei V. Chernov, Tony L. Yaksh, Alex Y. Strongin, Veronica I. Shubayev, Veronica I. Shubayev   +13 more
doaj   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

CRALBP is a Highly Prevalent Autoantigen for Human Autoimmune Uveitis [PDF]

, 2007
Cellular retinaldehyde binding protein (CRALBP) is an autoantigen in spontaneous equine recurrent uveitis. In order to test whether CRALBP contributes to human autoimmune uveitis, the specificity of antibodies from human uveitis patient's sera was first ...
Stephan R. Thurau, Wildner, Gerhild, Amann, Barbara, Ueffing, Marius, Barbara Amann, Marius Ueffing, Crabb, J.W., John W. Crabb, Crabb, John W., Manfred Stangassinger, Stefanie M. Hauck, Stangassinger, Manfred, Stangassinger, M., Deeg, Cornelia A., Hauck, Stefanie M., Cornelia A. Deeg, Amann, B., Thurau, Stephan R., Wildner, G., Raith, Albert J., Gerhild Wildner, Hauck, S.M., Ueffing, M., Albert J. Raith, Thurau, S.R., Deeg, C.A., Raith, A.J.   +26 more
core   +1 more source

Antigen Loading (e.g., Glutamic Acid Decarboxylase 65) of Tolerogenic DCs (tolDCs) Reduces Their Capacity to Prevent Diabetes in the Non-Obese Diabetes (NOD)-Severe Combined Immunodeficiency Model of Adoptive Cotransfer of Diabetes As Well As in NOD Mice

Frontiers in Immunology, 2018
Tolerogenic DCs (tolDCs) are being researched as a promising intervention strategy also in autoimmune diseases including type 1 diabetes (T1D). T1D is a T-cell-mediated, organ-specific disease with several well-defined and rather specific autoantigens, i.
David P. Funda, Jaroslav Goliáš, Tomáš Hudcovic, Hana Kozáková, Radek Špíšek, Radek Špíšek, Lenka Palová-Jelínková, Lenka Palová-Jelínková   +7 more
doaj   +1 more source

Periodontitis and atherosclerotic cardiovascular disease: A critical appraisal

Periodontology 2000, EarlyView., 2023
Abstract In spite of intensive research efforts driving spectacular advances in terms of prevention and treatments, cardiovascular diseases (CVDs) remain a leading health burden, accounting for 32% of all deaths (World Health Organization. “Cardiovascular Diseases (CVDs).” WHO, February 1, 2017, https://www.who.int/news‐room/fact‐sheets/detail ...
Maria Clotilde Carra, Hélène Rangé, Giuseppina Caligiuri, Philippe Bouchard   +3 more
wiley   +1 more source

Post-Aire maturation of thymic medullary epithelial cells involves selective expression of keratinocyte-specific autoantigens

Frontiers in Immunology, 2012
The autoimmune regulator (Aire)-directed ectopic expression of tissue-specific antigens (TSAs) by mature medullary thymic epithelial cells (mTECs) has been viewed as an essential mechanism in the induction of central tolerance.
Xiaoping eWang, Martti eLaan, Rudolf eBichele, Kai eKisand, Hamish S Scott, Hamish S Scott, Pärt ePeterson   +6 more
doaj   +1 more source