Results 31 to 40 of about 32,508 (252)

Glutamic Acid Decarboxylase Injection Into Lymph Nodes: Beta Cell Function and Immune Responses in Recent Onset Type 1 Diabetes Patients

Frontiers in Immunology, 2020
In spite of intensive treatment Type 1 diabetes leads to serious complications. Preservation of residual beta cell function makes the disease milder, facilitates treatment, prevents complications and increase survival.
Rosaura Casas, Fabrícia Dietrich, Hugo Barcenilla, Beatriz Tavira, Jeanette Wahlberg, Jeanette Wahlberg, Peter Achenbach, Johnny Ludvigsson, Johnny Ludvigsson   +8 more
doaj   +1 more source

Ars2‐containing bispecific, Fab‐ and IgG1‐format BAR‐bodies to target DLBCL cells

eJHaem, 2023
Despite recent advances in the therapy of diffuse large B‐cell lymphoma, not otherwise specified (DLBCL), around 30% of patients develop refractory disease or relapse after first‐line treatment. Recently, Ars2 was reported as the auto‐antigenic target of
Maximilian Kiefer, Lorenz Thurner, Theresa Bock, Onur Cetin, Igor Kos, Vadim Lesan, Dominic Kaddu‐Mulindwa, Joerg Thomas Bittenbring, Natalie Fadle, Evi Regitz, Markus Hoth, Frank Neumann, Klaus‐Dieter Preuss, Michael Pfreundschuh, Konstantinos Christofyllakis, Moritz Bewarder   +15 more
doaj   +1 more source

Low T-cell reactivity to TDP-43 peptides in ALS

Frontiers in Immunology, 2023
BackgroundDysregulation of the immune system in amyotrophic lateral sclerosis (ALS) includes changes in T-cells composition and infiltration of T cells in the brain and spinal cord.
Swetha Ramachandran, Veselin Grozdanov, Bianca Leins, Katharina Kandler, Simon Witzel, Medhanie Mulaw, Albert C. Ludolph, Albert C. Ludolph, Jochen H. Weishaupt, Karin M. Danzer, Karin M. Danzer   +10 more
doaj   +1 more source

Identification of TRAPPC4 as a Key Autoantigen in Immune- Related Pancytopenia: Epitope Characterization and Immune Activation Mechanisms

Turkish Journal of Hematology
Objective: Immune-related pancytopenia (IRP) is characterized by autoantibody-mediated destruction or suppression of bone marrow cells, leading to pancytopenia.
Shanfeng Hao, Yang Zhang, Na Xiao, Zonghong Shao   +3 more
doaj   +1 more source

The CYP2D6 animal model: how to induce autoimmune hepatitis in mice [PDF]

, 2012
Autoimmune hepatitis is a rare but life threatening autoimmune disease of the liver of unknown etiology1,2. In the past many attempts have been made to generate an animal model that reflects the characteristics of the human disease 3-5.
Christen, Urs, Hintermann, Edith, Ehser, Janine   +2 more
core   +1 more source

Antigen presentation, autoantigens and immune regulation in multiple sclerosis and other autoimmune diseases

Frontiers in Immunology, 2015
Antigen presentation is in the center of the immune system, both in host defence against pathogens, but also when the system is unbalanced and autoimmune diseases like multiple sclerosis (MS) develop.
Christine eRiedhammer, Robert eWeissert
doaj   +1 more source

CRALBP is a Highly Prevalent Autoantigen for Human Autoimmune Uveitis [PDF]

, 2007
Cellular retinaldehyde binding protein (CRALBP) is an autoantigen in spontaneous equine recurrent uveitis. In order to test whether CRALBP contributes to human autoimmune uveitis, the specificity of antibodies from human uveitis patient's sera was first ...
Stephan R. Thurau, Wildner, Gerhild, Amann, Barbara, Ueffing, Marius, Barbara Amann, Marius Ueffing, Crabb, J.W., John W. Crabb, Crabb, John W., Manfred Stangassinger, Stefanie M. Hauck, Stangassinger, Manfred, Stangassinger, M., Deeg, Cornelia A., Hauck, Stefanie M., Cornelia A. Deeg, Amann, B., Thurau, Stephan R., Wildner, G., Raith, Albert J., Gerhild Wildner, Hauck, S.M., Ueffing, M., Albert J. Raith, Thurau, S.R., Deeg, C.A., Raith, A.J.   +26 more
core   +1 more source

14-3-3ζ-A Novel Immunogen Promotes Inflammatory Cytokine Production

Frontiers in Immunology, 2019
The presence of autoantibodies against 14-3-3ζ in human autoimmune diseases indicates its antigenic function. However, neither the cause nor the consequence of this newly-identified antigenic function of 14-3-3ζ protein is known.
Jenna McGowan, Cara Peter, Saurabh Chattopadhyay, Ritu Chakravarti   +3 more
doaj   +1 more source

C-Reactive Protein: Friend or Foe? Phylogeny From Heavy Metals to Modified Lipoproteins and SARS-CoV-2

Frontiers in Cardiovascular Medicine, 2022
Animal C-reactive protein (CRP) has a widespread existence throughout phylogeny implying that these proteins have essential functions mandatory to be preserved.
Michael Torzewski
doaj   +1 more source

Oral delivery of bi-autoantigens by bacterium-like particles (BLPs) against autoimmune diabetes in NOD mice

Drug Delivery, 2023
Induction of oral tolerance by vaccination with type 1 diabetes mellitus (T1DM)-associated autoantigens exhibits great potential in preventing and treating this autoimmune disease.
Ruifeng Mao, Jin Wang, Ying Xu, Yuqi Wang, Mengmeng Wu, Lixia Mao, Yingying Chen, Dengchao Li, Tong Zhang, Enjie Diao, Zhenjing Chi, Yefu Wang, Xin Chang   +12 more
doaj   +1 more source