Results 51 to 60 of about 29,540 (247)

From Marginal to Central: Marginal Zone‐like B Cells as Critical Targets in Cladribine‐Treated Multiple Sclerosis

Annals of Neurology, EarlyView.
Objective Multiple sclerosis (MS) is a chronic autoimmune disease where B cells play a central pathogenic role. Cladribine, an oral therapy, provides durable benefits by reshaping lymphocyte populations, yet its specific long‐term impact on distinct B‐cell subsets is not fully understood.
Marta Pirronello, Mario Picozza, Gisella Guerrera, Silvia Corbisiero, Andrea Misiti, Roberta C. Placido, Alice Verdiani, Lorenzo de Marco, Manolo Sambucci, Elena Olivieri, Daniela F. Angelini, Esmeralda Quartuccio, Luca Prosperini, Carla Tortorella, Maria C. Buscarinu, Valeria Zancan, Francesca de Masi, Marco Salvetti, Claudio Gasperini, Giovanna Borsellino, Luca Battistini   +20 more
wiley   +1 more source

Molecular characteristics of the Goodpasture autoantigen

, 1993
Molecular characteristics of the Goodpasture autoantigen. Goodpasture syndrome is an autoimmune disease causing rapidly progressive glomerulonephritis and pulmonary hemorrhage.
Kalluri, Raghuram, Reeders, Stephen T., Hudson, Billy G., Noelken, Milton E., Mariyama, Mariko, Gunwar, Sripad   +5 more
core   +1 more source

Intralymphatic glutamic acid decarboxylase administration in type 1 diabetes patients induced a distinctive early immune response in patients with DR3DQ2 haplotype

Frontiers in Immunology, 2023
GAD-alum given into lymph nodes to Type 1 diabetes (T1D) patients participating in a multicenter, randomized, placebo-controlled double-blind study seemed to have a positive effect for patients with DR3DQ2 haplotype, who showed better preservation of C ...
Sara Puente-Marin, Fabrícia Dietrich, Peter Achenbach, Peter Achenbach, Hugo Barcenilla, Johnny Ludvigsson, Johnny Ludvigsson, Rosaura Casas   +7 more
doaj   +1 more source

Ribonucleoprotein complexes as autoantigens [PDF]

Current Opinion in Immunology, 1995
Many intracellular proteins and nucleic acids, that are involved in important biosynthetic pathways, are targeted by autoantibodies occurring spontaneously in the sera of patients with systemic autoimmune diseases. Frequently, the autoantigens are assembled into multicomponent complexes containing both nucleic acid(s) and proteins.
Venrooij, W.J. van, Pruijn, G.J.M.
openaire   +3 more sources

Interleukin‐2 Deprived State of Regulatory T cells and Their Recovery by Low‐Dose Interleukin‐2 in Patients With Inflammatory Myopathies

Arthritis &Rheumatology, EarlyView.
Objective Regeneration and expansion of Treg by low‐dose interleukin‐2 (IL‐2) therapy is considered a potential treatment strategy for a wide range of autoimmune diseases. To provide a pathophysiologically‐based rationale for low‐dose IL‐2 therapy, we investigated whether reversible defects in the Treg–IL‐2 axis emerge in inflammatory myopathies ...
Justus Ohmes, Luisa R. Monne, Sara Comdühr, Fynn Gerlach, Hanna Grasshoff, Alexander Dübbers, Antje Müller, Alexander Scheffold, Gabriela Riemekasten, Reza Akbarzadeh, Jens Y. Humrich   +10 more
wiley   +1 more source

Analysis of the interaction with the hepatitis C virus mRNA reveals an alternative mode of RNA recognition by the human La protein [PDF]

, 2011
23.04.14 KB.
Stephen Curry, Stephen J. Smerdon, Tam T. T. Bui, Kelly, Geoff, Drake, AF, Simon Pennell, Kotik-Kogan, O, Martino, Luigi, Pennell, Simon, Smerdon, Stephen J., Alex F. Drake, Conte, MR, Geoff Kelly, Kotik-Kogan, Olga, Bui, TTT, Smerdon, SJ, Bui, Tam T. T.; id_orcid, Martino, L, Pennell, S, Curry, Stephen, Conte, Maria R.; id_orcid, Kelly, G, Curry, S, Olga Kotik-Kogan, Drake, Alex F., Luigi Martino, Maria R. Conte   +26 more
core   +1 more source

Intranasal sensitization model of alopecia areata using pertussis toxin as adjuvant

Frontiers in Immunology
BackgroundNasopharyngeal Bordetella pertussis (BP) colonization is common, with about 5% of individuals having PCR evidence of subclinical BP infection on nasal swab, even in countries with high vaccination rates. BP secretes pertussis toxin (PTx).
Yuying Liu, Jasmin Freeborn, Beanna Okeugo, Shabba A. Armbrister, Zeina M. Saleh, Ana Beatriz Fadhel Alvarez, Thomas K. Hoang, Evelyn S. Park, John William Lindsey, Ronald P. Rapini, Steven Glazer, Keith Rubin, Jon Marc Rhoads   +12 more
doaj   +1 more source

Glutamic Acid Decarboxylase Injection Into Lymph Nodes: Beta Cell Function and Immune Responses in Recent Onset Type 1 Diabetes Patients

Frontiers in Immunology, 2020
In spite of intensive treatment Type 1 diabetes leads to serious complications. Preservation of residual beta cell function makes the disease milder, facilitates treatment, prevents complications and increase survival.
Rosaura Casas, Fabrícia Dietrich, Hugo Barcenilla, Beatriz Tavira, Jeanette Wahlberg, Jeanette Wahlberg, Peter Achenbach, Johnny Ludvigsson, Johnny Ludvigsson   +8 more
doaj   +1 more source

Ars2‐containing bispecific, Fab‐ and IgG1‐format BAR‐bodies to target DLBCL cells

eJHaem, 2023
Despite recent advances in the therapy of diffuse large B‐cell lymphoma, not otherwise specified (DLBCL), around 30% of patients develop refractory disease or relapse after first‐line treatment. Recently, Ars2 was reported as the auto‐antigenic target of
Maximilian Kiefer, Lorenz Thurner, Theresa Bock, Onur Cetin, Igor Kos, Vadim Lesan, Dominic Kaddu‐Mulindwa, Joerg Thomas Bittenbring, Natalie Fadle, Evi Regitz, Markus Hoth, Frank Neumann, Klaus‐Dieter Preuss, Michael Pfreundschuh, Konstantinos Christofyllakis, Moritz Bewarder   +15 more
doaj   +1 more source

HLA-DR3 restricted environmental epitopes from the bacterium Clostridium tetani have T cell cross-reactivity to the SLE-related autoantigen SmD

Frontiers in Immunology, 2022
HLA-DR3 (DR3) is one of the dominant HLA-DR alleles associated with systemic lupus erythematosus (SLE) susceptibility. Our previous studies showed multiple intramolecular DR3 restricted T cell epitopes in the Smith D (SmD) protein, from which we ...
Zhenhuan Zhao, Zhenhuan Zhao, Ashley N. Anderson, Carol C. Kannapell, Carol C. Kannapell, William W. Kwok, Felicia Gaskin, Shu Man Fu, Shu Man Fu   +8 more
doaj   +1 more source