Results 61 to 70 of about 29,540 (247)

Anti‐Carbamylated Protein Antibodies Stabilize Carbamylated Histone H3 to Promote Synovial Activation and Neutrophil Extracellular Trap‐Mediated Bone Loss in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Carbamylation, a nonenzymatic post‐translational modification, contributes to rheumatoid arthritis (RA) pathogenesis. Anti‐carbamylated protein antibodies (anti‐CarP) occur in around 50% of patients with RA and associate with greater joint damage. Neutrophil extracellular traps (NETs) are a major source of carbamylated autoantigens. We sought
Shuichiro Nakabo, Norio Hanata, Eduardo Patino‐Martinez, Ronald Holewinski, Ana Barrera‐Vargas, Javier Merayo‐Chalico, Scott A. Coonrod, David A. Fox, Mariana J. Kaplan, Carmelo Carmona‐Rivera   +9 more
wiley   +1 more source

Reduced Competitiveness of Autoantigen-Engaged B Cells due to Increased Dependence on BAFF

, 2004
Peripheral autoantigen binding B cells are poorly competitive with naive B cells for survival and undergo rapid cell death. However, in monoclonal Ig-transgenic mice lacking competitor B cells, autoantigen binding B cells can survive for extended periods.
Ying Xu, Robin Lesley, Jason G Cyster, Shu, Hong-Bing, Cyster, Jason G, Hong-Bing Shu, Donna M Hess, Kalled, Susan L, Susan L Kalled, Schwab, Susan R, Hess, Donna M, Lesley, Robin, Xu, Ying, Susan R Schwab   +13 more
core   +1 more source

Anti-PGK1 antibodies in immuno-related pancytopenia

Hematology
Objective Phosphoglycerate kinase 1 (PGK1) was previously screened as a possible autoantigen for IRP, this study further investigates the value of PGK1 autoantibodies in the diagnosis of IRP and their correlation with other clinical indicators.Method ...
Shanfeng Hao, Yang Zhang, Na Xiao, Rong Fu, Zonghong Shao   +4 more
doaj   +1 more source

Immune Complexes Shape the Pathogenicity of Autoantibodies in Systemic Autoimmune Diseases: Insights From an FcγRIIIA‐Reporter Assay

Arthritis &Rheumatology, EarlyView.
Objective Immune complexes (ICs), formed by autoantigen and autoantibody, play a pathogenic role in systemic autoimmune diseases through stimulation of Fcγ receptors (FcγR). However, studies investigating bioactivity of circulating ICs across various diseases remain limited.
Koji Suzuki, Masaru Takeshita, Yuki Imai, Hiroyuki Fukui, Kazunori Furuhashi, Kotaro Matsumoto, Jun Kikuchi, Keiko Yoshimoto, Yuko Kaneko   +8 more
wiley   +1 more source

Unbiased autoantibody screening using nucleic acid protein programmable array in pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections

Frontiers in Behavioral Neuroscience
IntroductionPediatric autoimmune neuropsychiatric disorder associated with streptococcal infections (PANDAS) is characterized by the abrupt onset of obsessive-compulsive disorder and/or tics, along with other neuropsychiatric symptoms in children, in the
Jelena Eremija, Michael Daines, Sydney Rice, Juliette C. Madan, Juliette C. Madan, Susan Swedo, Fayez K. Ghishan, Pawel R. Kiela, Pawel R. Kiela   +8 more
doaj   +1 more source

Clock Genes Regulate Ca2+ Signaling and Mitochondrial Bioenergetics to Inhibit Sjögren Disease

Arthritis &Rheumatology, EarlyView.
Objective Although Ca2+ signaling and metabolism have been identified as key determinants for the development of Sjögren disease (SjD), the intricate connection between them and salivary gland physiology remains poorly understood. Methods Fluorescence‐based Ca2+ imaging, RNA sequencing, and mitochondrial activity were used to investigate the effects of
Viktor R. Drel, Manigandan Venkatesan, Rahul S. Jasrotia, Yuyang Sun, Viviane Nascimento da Conceicao, Neelanjan Vishnu, Shankara N. Varadarajan, Venugopal R. Bovilla, Rajender K. Motiani, Shobhan Gaddameedhi, Bibhuti B. Mishra, Muniswamy Madesh, Brij B. Singh   +12 more
wiley   +1 more source

Glycoproteins as targets of autoantibodies in CNS inflammation: MOG and more [PDF]

, 2012
B cells and antibodies constitute an important element in different inflammatory diseases of the central nervous system (CNS). Autoantibodies can serve as a biomarker to identify disease subgroups and may in addition contribute to the pathogenic process.
Mayer, Marie Cathrin, Meinl, Edgar, Marie Cathrin Mayer, Edgar Meinl, Meinl, E., Mayer, M.   +5 more
core   +1 more source

PDB: 1ADQ, human IgM RH in complex with autoantigen IgG (310K, 37°C, 100 ns)

, 2023
Human IgM RH in complex with autoantigen IgG (310K, 37°C, 100 ns).
Stan, Razvan
core   +1 more source

Antigen presentation, autoantigens and immune regulation in multiple sclerosis and other autoimmune diseases

Frontiers in Immunology, 2015
Antigen presentation is in the center of the immune system, both in host defence against pathogens, but also when the system is unbalanced and autoimmune diseases like multiple sclerosis (MS) develop.
Christine eRiedhammer, Robert eWeissert
doaj   +1 more source

Autoreactivity vs autoimmunity: characteristics of autoantigen‐specific CD4 T‐cells in rheumatoid arthritis and health.

Arthritis &Rheumatology, Accepted Article.
Background CD4 T cells specific for citrullinated (cit)‐peptides are key players in RA immunopathogenesis. Characterising these cells and identifying features of healthy and RA‐associated autoreactivity will provide valuable insight into disease mechanisms and form the basis of immune state biomarkers to facilitate the next generation of RA treatments.
James A. Stanway, Daniel Peters, Helen Waller, Jeremy Lakey, Henrique De Paula Lemos, Kristian Williams, Abbie Degnan, Julie Diboll, Abdul Mannan Baru, David Tough, Arthur G. Pratt, Catharien M.U. Hilkens, Amy E. Anderson, John D. Isaacs   +13 more
wiley   +1 more source