Results 61 to 70 of about 32,508 (252)

Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice [PDF]

, 2015
Background & AimsIt is well-known that the liver can induce immune tolerance, yet this knowledge could, thus far, not be translated into effective treatments for autoimmune diseases. We have previously shown that liver sinusoidal endothelial cells (LSECs)
Reimer, Rudolph, Huber, Samuel, Freund, Barbara, Salmen, Sunhild C., Schramm, Christoph, Lüth, Stefan, Korn, Thomas, Schwinge, Dorothee, Christoph Schramm, Harald Ittrich, Samuel Huber, Waurisch, Christian, Johannes Herkel, Wraith, David C, Rudolph Reimer, Heine, Markus, Heeren, Joerg, Lohse, Ansgar W, Christian Waurisch, Wraith, David C., Alexander Eychmüller, Eychmüller, Alexander, Bruns, Oliver T, David C. Wraith, Salmen, Sunhild C, Ittrich, Harald, Bruns, Oliver T., Stefan Lüth, Lohse, Ansgar W., Dorothee Schwinge, Joerg Heeren, Weller, Horst, Peter Nielsen, Thomas Korn, Markus Heine, Carambia, Antonella, Herkel, Johannes, Antonella Carambia, Sunhild C. Salmen, Horst Weller, Ansgar W. Lohse, Barbara Freund, Oliver T. Bruns, Nielsen, Peter   +43 more
core   +2 more sources

Intranasal sensitization model of alopecia areata using pertussis toxin as adjuvant

Frontiers in Immunology
BackgroundNasopharyngeal Bordetella pertussis (BP) colonization is common, with about 5% of individuals having PCR evidence of subclinical BP infection on nasal swab, even in countries with high vaccination rates. BP secretes pertussis toxin (PTx).
Yuying Liu, Jasmin Freeborn, Beanna Okeugo, Shabba A. Armbrister, Zeina M. Saleh, Ana Beatriz Fadhel Alvarez, Thomas K. Hoang, Evelyn S. Park, John William Lindsey, Ronald P. Rapini, Steven Glazer, Keith Rubin, Jon Marc Rhoads   +12 more
doaj   +1 more source

Homocitrullinated Peptides Drive Pro‐Inflammatory T Cell Responses in a Humanized Mouse Model of Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Anti‐homocitrullinated protein/peptide antibodies are specific to rheumatoid arthritis (RA) and predictive of worse prognosis, suggesting a pathogenic role for autoreactivity to homocitrullinated peptides (HomoCitP). However, T cell responses to HomoCitP remain largely unexplored.
Sofya Ulanova, Jaspreet Kaur, Gabrielle Buckley, S. M. Mansour Haeryfar, Lisa Cameron, Ewa Cairns, Lillian Barra   +6 more
wiley   +1 more source

Anti-PGK1 antibodies in immuno-related pancytopenia

Hematology
Objective Phosphoglycerate kinase 1 (PGK1) was previously screened as a possible autoantigen for IRP, this study further investigates the value of PGK1 autoantibodies in the diagnosis of IRP and their correlation with other clinical indicators.Method ...
Shanfeng Hao, Yang Zhang, Na Xiao, Rong Fu, Zonghong Shao   +4 more
doaj   +1 more source

Anti–Carbamylated Fibrinogen Autoantibodies of IgG and IgA Isotypes Contribute to a Better Prognostic Stratification in Very Early Rheumatoid Arthritis: Data From the French National ESPOIR Cohort

Arthritis &Rheumatology, EarlyView.
Objective The aim of this study was to investigate the prevalence and longitudinal evolution of anti–carbamylated fibrinogen antibodies (ACa‐Fib) of IgG and IgA isotypes in early rheumatoid arthritis (RA) and determine whether these antibodies provide additional diagnostic and prognostic information beyond anti–cyclic citrullinated peptide (anti‐CCP ...
Pauline Brevet, Olivia Guérin, Léna Le Goaréguer, Élisa Halbourg, Marie‐Laure Golinski, Sophie Candon, Olivier Boyer, Thierry Lequerré, Thierry Schaeverbeke, Valérie Devauchelle‐Pensec, Olivier Vittecoq, Manuel Fréret   +11 more
wiley   +1 more source

Characteristics and specificity of luciferase-SSc autoantigen constructs.

, 2019
Characteristics and specificity of luciferase-SSc autoantigen constructs.
Jess D. Edison (162221), James B. Hughes (6508712), Stephen W. Olson (6508715), Dustin J. Little (622868), Rodger S. Stitt (6508706), Peter D. Burbelo (135490), Wayne T. Bailey (6508709), Meryl Waldman (6508703), Sarah M. Gordon (6508700)   +8 more
core   +1 more source

Unbiased autoantibody screening using nucleic acid protein programmable array in pediatric autoimmune neuropsychiatric disorder associated with streptococcal infections

Frontiers in Behavioral Neuroscience
IntroductionPediatric autoimmune neuropsychiatric disorder associated with streptococcal infections (PANDAS) is characterized by the abrupt onset of obsessive-compulsive disorder and/or tics, along with other neuropsychiatric symptoms in children, in the
Jelena Eremija, Michael Daines, Sydney Rice, Juliette C. Madan, Juliette C. Madan, Susan Swedo, Fayez K. Ghishan, Pawel R. Kiela, Pawel R. Kiela   +8 more
doaj   +1 more source

Cancer in Systemic Sclerosis: Clinical Associations and Prognostic Impact From the EUSTAR Registry

Arthritis &Rheumatology, EarlyView.
Objective Cancer represents a major cause of death in systemic sclerosis (SSc). Established risk factors are limited to specific subsets, particularly early diffuse anti‐RNA polymerase III (POLR3)–positive disease, needing further exploration. Methods We performed a nested case‐control study within the European Scleroderma Trials and Research group ...
Antonio Tonutti, Francesca Motta, Liala Moschetti, Cosimo Bruni, Carina Mihai, Claudia Iannone, Maria Rosa Pellico, Stefano Stano, Stefano Erba, Claudia Barison, Eleonora Pazzi, Andrea Benini, Beatrice Moccaldi, Kurszán Jász Dávid, Ágnes Ágoston‐Szabó, Beatrice Gabrielli, Francesca Nava, Dóra Tari, Francesca Romana Di Ciommo, Yuri Sasaki, Gonçalo Boleto, Radim Bečvář, Alejandro Brigante, Britta Maurer, Massimiliano Limonta, Rahma A. Elziaty, Fabiola Atzeni, Lilian Maria López Núñez, Roberta Foti, Francesco Benvenuti, Brigitte Granel, Elena Rezus, Leila Caillault, Sophie Blaise, Cristiana Sieiro Santos, Fabio Cacciapaglia, Roberto Giacomelli, Rossella De Angelis, Serena Guiducci, Duygu Temiz Karadag, Gabriella Szűcs, Luca Idolazzi, Gábor Kumánovics, Florenzo Iannone, Maurizio Cutolo, Gianluca Moroncini, Valeria Riccieri, Nicoletta Del Papa, Elisabetta Zanatta, Oliver Distler, Masataka Kuwana, Carlo Selmi, Maria De Santis   +52 more
wiley   +1 more source

Research progress on the pathogenesis of Graves’ ophthalmopathy: Based on immunity, noncoding RNA and exosomes

Frontiers in Immunology, 2022
Graves’ ophthalmopathy (GO), also known as thyroid-associated ophthalmopathy, is a common potentially vision-threatening organ-specific autoimmune disease and the most common extrathyroidal manifestation of Graves’ disease.
Jingyi Zheng, Jingyi Zheng, Honghong Duan, Sufang You, Sufang You, Bo Liang, Yuping Chen, Yuping Chen, Huibin Huang   +8 more
doaj   +1 more source

Treatment‐driven peripheral blood transcriptomic remodelling and baseline predictors of ESSDAI and STAR response to B‐cell therapy in Sjögren's disease

Arthritis &Rheumatology, Accepted Article.
Objective To characterise whole‐blood transcriptomic profiles in adults with active Sjögren's disease (SjD) treated with anti‐CD20 or BlyS/BAFF inhibition, identify markers of clinical response, and define inflammatory pathways linked to non‐response. Methods Whole‐blood RNA sequencing was performed at baseline and week‐24 in participants (n=43) from a
Aimen Ibrahim, Junjie Peng, Eileen Tian, Lucia Martin‐Gutierrez, John Casement, Kyle Thompson, Wan‐Fai Ng, André van Maurik, Elizabeth C Jury, Coziana Ciurtin   +9 more
wiley   +1 more source