Results 71 to 80 of about 29,540 (247)
Characteristics and specificity of luciferase-SSc autoantigen constructs.
, 2019 Characteristics and specificity of luciferase-SSc autoantigen constructs.
Jess D. Edison (162221) +8 more
core +1 more source
Chimeric autoantibody receptor T cells specifically eliminate Graves’ Disease autoreactive B cells
Frontiers in ImmunologyIntroductionChimeric antigen receptor (CAR) T cells have recently become an important treatment for hematological cancers by efficiently eliminating B cells.
Abigail Cheever +6 more
doaj +1 more source
The nature of autoantigens [PDF]
Memórias do Instituto Oswaldo Cruz, 1987 1. Autoimmunity in deisease is driven by autoantigen; 2. Cell surface molecules may stimulate autoreactive T-helpers if call II MHC is expressed; special factors may predispose to the ease of class II induction; 3. Soluble autoantigens may be focussed by primed B-cells and processed for presentation to T-cell; 4.
Roitt, Ivan M., Cooke, Anne
openaire +3 more sources
Arthritis &Rheumatology, EarlyView.Objective Anti‐homocitrullinated protein/peptide antibodies are specific to rheumatoid arthritis (RA) and predictive of worse prognosis, suggesting a pathogenic role for autoreactivity to homocitrullinated peptides (HomoCitP). However, T cell responses to HomoCitP remain largely unexplored.
Sofya Ulanova +6 more
wiley +1 more source
Autoantigen microarrays for multiplex characterization of autoantibody responses.
, 2002 We constructed miniaturized autoantigen arrays to perform large-scale multiplex characterization of autoantibody responses directed against structurally diverse autoantigens, using submicroliter quantities of clinical samples.
Hirschberg, D.L. +19 more
core +1 more source
14-3-3ζ-A Novel Immunogen Promotes Inflammatory Cytokine Production
Frontiers in Immunology, 2019 The presence of autoantibodies against 14-3-3ζ in human autoimmune diseases indicates its antigenic function. However, neither the cause nor the consequence of this newly-identified antigenic function of 14-3-3ζ protein is known.
Jenna McGowan +3 more
doaj +1 more source
The Structure of Thyroid Autoantigens
Autoimmunity, 1990 There are three distinct and well characterized thyroid autoantigens-thyroglobulin (Tg), thyroid peroxidase (microsomal antigen/TPO) and the TSH receptor. Auto-antibodies to the TSH receptor are responsible for hyperthyroidism in Graves' disease whereas antibodies to TPO and Tg are associated with the hypothyroidism of Hashimoto's disease and primary ...
J, Furmaniak, B R, Smith
openaire +2 more sources
Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications
Barrier Immunity, EarlyView.A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu +9 more
wiley +1 more source
The CYP2D6 animal model: how to induce autoimmune hepatitis in mice
, 2012 Autoimmune hepatitis is a rare but life threatening autoimmune disease of the liver of unknown etiology1,2. In the past many attempts have been made to generate an animal model that reflects the characteristics of the human disease 3-5.
Christen, Urs +2 more
core +1 more source
PDB: 1ADQ, human IgM RH in complex with autoantigen IgG (312K, 39°C, 100 ns)
, 2023 Human IgM RH in complex with autoantigen IgG (312K, 39°C, 100 ns).
Stan, Razvan
core +1 more source