Results 81 to 90 of about 32,508 (252)

Antigen Loading (e.g., Glutamic Acid Decarboxylase 65) of Tolerogenic DCs (tolDCs) Reduces Their Capacity to Prevent Diabetes in the Non-Obese Diabetes (NOD)-Severe Combined Immunodeficiency Model of Adoptive Cotransfer of Diabetes As Well As in NOD Mice

Frontiers in Immunology, 2018
Tolerogenic DCs (tolDCs) are being researched as a promising intervention strategy also in autoimmune diseases including type 1 diabetes (T1D). T1D is a T-cell-mediated, organ-specific disease with several well-defined and rather specific autoantigens, i.
David P. Funda, Jaroslav Goliáš, Tomáš Hudcovic, Hana Kozáková, Radek Špíšek, Radek Špíšek, Lenka Palová-Jelínková, Lenka Palová-Jelínková   +7 more
doaj   +1 more source

The Structure of Thyroid Autoantigens

Autoimmunity, 1990
There are three distinct and well characterized thyroid autoantigens-thyroglobulin (Tg), thyroid peroxidase (microsomal antigen/TPO) and the TSH receptor. Auto-antibodies to the TSH receptor are responsible for hyperthyroidism in Graves' disease whereas antibodies to TPO and Tg are associated with the hypothyroidism of Hashimoto's disease and primary ...
J, Furmaniak, B R, Smith
openaire   +2 more sources

Integrative proteomic profiling of extracellular vesicle‐enriched preparations with machine learning identifies disease activity‐associated signatures linked to adverse pregnancy outcomes in systemic lupus erythematosus

VIEW, EarlyView.
Integrating cross‐cohort extracellular vesicle proteomics with machine learning identifies a simplified protein signature (AGT, FETUB, SPP2, and FCN3) for adverse pregnancy outcome risk stratification in systemic lupus erythematosus, enabling precise disease‐activity discrimination beyond routine clinical assessment.
Weiwei Shi, Xipei Huang, Wutao Chen, Wen Di, Lin Huang, You Wang   +5 more
wiley   +1 more source

Post-Aire maturation of thymic medullary epithelial cells involves selective expression of keratinocyte-specific autoantigens

Frontiers in Immunology, 2012
The autoimmune regulator (Aire)-directed ectopic expression of tissue-specific antigens (TSAs) by mature medullary thymic epithelial cells (mTECs) has been viewed as an essential mechanism in the induction of central tolerance.
Xiaoping eWang, Martti eLaan, Rudolf eBichele, Kai eKisand, Hamish S Scott, Hamish S Scott, Pärt ePeterson   +6 more
doaj   +1 more source

Differential Effects of Dupilumab in a Patient With Localized Heat Urticaria, Delayed Solar Urticaria, and Symptomatic Dermographism

The Journal of Dermatology, EarlyView.
ABSTRACT Physical urticaria is a subtype of chronic inducible urticaria characterized by wheals and/or angioedema triggered by physical stimuli. We report a refractory case of combined localized heat urticaria, delayed solar urticaria, and symptomatic dermographism in a 16‐year‐old girl.
Shuta Yoshitani, Shinichi Moriwaki, Atsushi Fukunaga   +2 more
wiley   +1 more source

PDB: 1ADQ, human IgM RH in complex with autoantigen IgG (310K, 37°C, 100 ns)

, 2023
Human IgM RH in complex with autoantigen IgG (310K, 37°C, 100 ns).
Stan, Razvan
core   +1 more source

CD8+-T Cells With Specificity for a Model Antigen in Cardiomyocytes Can Become Activated After Transverse Aortic Constriction but Do Not Accelerate Progression to Heart Failure

Frontiers in Immunology, 2018
Heart failure due to pressure overload is frequently associated with inflammation. In addition to inflammatory responses of the innate immune system, autoimmune reactions of the adaptive immune system appear to be triggered in subgroups of patients with ...
Carina Gröschel, Carina Gröschel, André Sasse, Sebastian Monecke, Sebastian Monecke, Charlotte Röhrborn, Leslie Elsner, Michael Didié, Michael Didié, Michael Didié, Verena Reupke, Gertrude Bunt, Andrew H. Lichtman, Karl Toischer, Karl Toischer, Wolfram-Hubertus Zimmermann, Wolfram-Hubertus Zimmermann, Gerd Hasenfuß, Gerd Hasenfuß, Ralf Dressel, Ralf Dressel   +20 more
doaj   +1 more source

Lupus Panniculitis Immunoprofiling Reveals a Cytotoxic, Type 1‐Skewed T‐Cell Response With Signs of Metabolic Alteration

Allergy, EarlyView.
Imaging mass cytometry shows lupus panniculitis lesions are dominated by cytotoxic and skin‐homing T cells with abundant macrophages and B‐cell aggregates. Spatial neighborhood analysis reveals organized leukocyte architecture, including B‐cell proximity to naïve T cells and M1 macrophages to cytotoxic T cells.
Milad Ameri, Reihane Ziadlou, Stephan Traidl, Milena Sokolowska, Emmanuel Contassot, Nick Li, Maija Kiuru, Isabel Kolm, Werner Kempf, Emanual Maverakis, Cezmi Akdis, Marie‐Charlotte Brüggen   +11 more
wiley   +1 more source

Diacerein Disrupts Testicular Homeostasis: The Essential Role of Basal Cytokines in Maintaining Sertoli Cell Integrity and the Immune Microenvironment

Andrology, EarlyView.
ABSTRACT Background Pro‐inflammatory cytokines, TNF and IL‐1B, are essential for testicular homeostasis. Diacerein, an anti‐inflammatory drug, inhibits these cytokines, impairing M2 macrophages and Leydig cells (LCs). However, its impact on Sertoli cells (SCs) and M1 (CD68) macrophages remains unknown.
Elide Loise Freitas de Jesus, André Acácio Souza da Silva, Olumide Stephen Akinsomisoye, Erick J. R. Silva, Paulo Sérgio Cerri, Salmo Azambuja de Oliveira, Estela Sasso‐Cerri   +6 more
wiley   +1 more source

Desmoglein-1 is a minor autoantigen in dogs with pemphigus foliaceus

, 2006
The majority of human patients with pemphigus foliaceus (PF) have circulating IgG autoantibodies that target conformational epitopes on the desmosomal cadherin desmoglein-1 (dsg1).
Prisayanh, Phillip, Dunston, Stanley M, Suter, Maja M, Simon J. Warren, Gregg A. Dean, Thierry Olivry, Phillip Prisayanh, Müller, Eliane J, Elizabeth M. Lennon, Rachel S. Brown, LaVoy, Alora, Alora LaVoy, Stanley M. Dunston, Lennon, Elizabeth M, Eliane J. Müller, Brown, Rachel S, Olivry, Thierry, Dean, Gregg A, Maja M. Suter, Warren, Simon J   +19 more
core   +1 more source