Results 101 to 110 of about 29,540 (247)

Cardiovascular toxicity from immune checkpoint inhibitor therapy: an inflammatory continuum

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitor (ICI) therapy has markedly improved outcomes in advanced malignancies but has also revealed a distinct spectrum of cardiovascular immune‐related adverse events. Myocarditis represents the most severe manifestation, while non‐inflammatory left ventricular dysfunction and vascular inflammation have emerged as additional ...
Fabrice Reyes, Florian Buehning, Tobias Lerchner, Julia Vogel, Raluca I. Mincu, Matthias Totzeck, Tienush Rassaf, Lars Michel   +7 more
wiley   +1 more source

Cold plasma treatment for oral lichen planus: a retrospective case collection and proposal of a new clinical score

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and objectives Oral lichen planus (OLP) is a chronic autoimmune mucosal disease with malignant potential and limited treatment options. This study evaluated the long‐term efficacy and safety of cold atmospheric plasma (CAP) therapy in therapy‐refractory OLP and introduced the novel Lichen Planus Severity Score (LPSS).
Christian Seebauer, Hans‐Robert Metelmann, Mohamed Falougy, Wolfram Kaduk, Lasse Kremer, Georg Daeschlein   +5 more
wiley   +1 more source

Anti‐Integrin αvβ6 Autoantibodies as Diagnostic and Monitoring Biomarkers for Pediatric‐Onset Primary Sclerosing Cholangitis

Hepatology Research, EarlyView.
Levels of anti‐integrin αvβ6 antibodies were significantly higher in pediatric‐onset primary sclerosing cholangitis (PSC) than in autoimmune hepatitis (AIH) and may reflect disease activity. These antibodies may serve as a novel biomarker for distinguishing PSC from AIH and for monitoring disease progression.
Yukako Maeda, Shuichiro Umetsu, Eitaro Hiejima, Mitsuyoshi Suzuki, Itaru Iwama, Takeshi Kimura, Sonoko Kondo, Ayano Inui, Hiroki Kondou, Tatsuya Okamoto, Takashi Ito, Hiroyuki Shirahase, Kazushi Izawa, Takahiro Yasumi, Takeshi Kuwada, Masahiro Shiokawa, Hiroshi Seno, Junko Takita   +17 more
wiley   +1 more source

Positive rate of autoantibodies observed in CSF validation cohort with focused autoantigen microarrays.

, 2016
Positive rate of autoantibodies observed in CSF validation cohort with focused autoantigen microarrays.
Wei Huang (36889), Fengchun Zhang (309978), Lin Wu (153444), Xuan Zhang (56049), Chaojun Hu (687165), Guang Song (733747), Qiang Shan (195130), Heng Zhu (50460), Yongzhe Li (528191), Hua Chen (43790), Ping Li (31981)   +10 more
core   +1 more source

Tissue Resident Memory Cells: Friend or Foe?

Immunology, EarlyView.
Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude, Jude E. Uzonna, Janilyn Arsenio   +2 more
wiley   +1 more source

Identification of Hnrph3 as an autoantigen for acute anterior uveitis

, 2011
Acute anterior uveitis (AAU) is the most common form of autoimmune uveitis in the eye with few known autoantigens. Identification of autoantigens will improve our understanding of the molecular mechanisms and capability for disease diagnosis.
Caberoy, Nora B, Feuer, William J, Li, Wei, Nora B. Caberoy, Wei Li, Kim, Youngbae, Davis, Janet L, Youngbae Kim, Janet L. Davis, Alvarado, Gabriela, Gabriela Alvarado, William J. Feuer   +11 more
core   +1 more source

The Transcription Factor EGR2 Plays a Central Role in the Expansion and Function of TCRαβ+CD4−CD8− Double Negative T Cells in lpr Lupus Mice

Immunology, EarlyView.
The highly expanded TCRβ+ DNT cells in autoimmune‐prone B6/lpr mice are phenotypically and functionally different from the TCRβ+DNT cells of normal B6 mice. Conditional Egr2 deletion in B6/lpr mice not only reduces TCRβ+ DNT cell numbers but also tends to correct the phenotypic and functional abnormalities of DNT cells in B6/lpr mice. In addition, Egr2
Rujuan Dai, Zhuang Wang, Bettina Heid, Christopher M. Reilly, S. Ansar Ahmed   +4 more
wiley   +1 more source

Transfer of hematopoietic stem cells encoding autoantigen prevents autoimmune diabetes

, 2003
Bone marrow or hematopoietic stem cell transplantation is a potential treatment for autoimmune disease. The clinical application of this approach is, however, limited by the risks associated with allogeneic transplantation.
Steptoe, Raymond J., Ritchie, Janine M., Harrison, Leonard C., Janine M. Ritchie, Leonard C. Harrison, Raymond J. Steptoe   +5 more
core   +1 more source

Pathophysiology and emerging treatments for dermographic, cholinergic and cold urticaria

Journal of the European Academy of Dermatology and Venereology, EarlyView.
This review illustrates key proposed mast cell‐mediated activation pathways in dermographic, cholinergic and cold urticaria, highlighting IgE‐dependent and ‐independent mechanisms. These pathways are increasingly targeted by emerging drugs, aiming to interrupt mast cell activation and mediator release, offering more precise, mechanism‐based treatment ...
Mojca Bizjak‐Suran, Matjaž Fležar, Manuel Pedro Pereira   +2 more
wiley   +1 more source

Autoimmunity and Periodontitis

Journal of Periodontal Research, EarlyView.
In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga, Vivek Thumbigere‐Math, Mark C. Herzberg   +2 more
wiley   +1 more source