Results 121 to 130 of about 29,540 (247)

CAR‐T Cells in Ulcerative Colitis: The Renaissance of B‐Cell Targeted Therapy in UC

JCC Plus, Volume 1, Issue 4, July 2026.
ABSTRACT A recent New England Journal of Medicine report described the first successful use of anti‐CD19 CAR‐T cell therapy in a patient with multirefractory ulcerative colitis (UC). This exceptional case provides striking proof of concept that B cells and plasma cells can act as key pathogenic drivers in UC.
Zlata Chkolnaia, Mathieu Uzzan, Walter Reinisch   +2 more
wiley   +1 more source

Proinsulin-Loaded Nanoparticles Suppress Insulitis and Induce Temporary Diabetes Remission

Cells
Autoimmune type 1 diabetes (T1D) results from the failure of the physiologic regulatory mechanisms that are designed to maintain immune tolerance to pancreatic beta cells.
Maeva Agapoff, Chloé Dubreil, Emmanuelle Waeckel-Énée, Frédéric Geinguenaud, Valérie Manceau, Julien Diana, Barbara Bertocci, Laurence Motte, Peter van Endert   +8 more
doaj   +1 more source

Thymus and Leishmania at the Crossroads: Autoimmunity and Cancer

Immunology, Volume 178, Issue 3, Page 377-386, July 2026.
Conceptual ‘Crossroads Model’ linking Leishmania, thymic infection and immune dysregulation: an integrative model is proposed in which Leishmania infection disrupts thymic architecture and stromal–thymocyte interactions. These alterations converge to promote defective tolerance, increased autoimmune risk and a microenvironment permissive to malignant ...
Alef Batista Bezerra Barros, Gabriel Augusto Leite, Arthur Gomes de Andrade, Maria Danielma dos Santos Reis, Luiz Henrique Agra Cavalcante‐Silva, Marvin Paulo Lins   +5 more
wiley   +1 more source

Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection

, 2009
Autoimmune hepatitis (AIH) is a chronic liver disease of unknown etiology, characterized by a loss of tolerance against hepatocytes leading to the progressive destruction of hepatic parenchyma and cirrhosis. Clinical signs for AIH are interface hepatitis
Holdener, Martin
core  

Anisoosmotic regulation of the Mi-2 autoantigen mRNA in H4IIE rat hepatoma cells and primary hepatocytes

, 1998
Using the differential display polymerase chain reaction (DDRT-PCR) a 169 bp cDNA product, which is 88.8% homologous to the human Mi-2β autoantigen, was identified in H4IIE rat hepatoma cells. At protein level 100% homology was found.
Ulrich Warskulat, Rainer Hammermann, Dieter Häussinger, Hammermann, Rainer, Häussinger, Dieter, Warskulat, Ulrich   +5 more
core   +1 more source

Unsupervised Flow Cytometry Reveals a Constant Shift Towards Activated CD4+ T Cell Subsets in APECED

Scandinavian Journal of Immunology, Volume 104, Issue 1, July 2026.
APECED is caused by mutations of AIRE that impair negative selection in the human thymus. Using our optimized unsupervised workflow, we reveal that APECED patients show increased activation of T cells and alterations to their Treg pool as well as a novel T cell population not found among healthy controls.
Joonatan Mattila, Nelli Heikkilä, Iivo Hetemäki, Joonatan Borchers, Outi Mäkitie, Saila Laakso, T Petteri Arstila   +6 more
wiley   +1 more source

Islet cell autoantigen 69 kD (ICA69). Molecular cloning and characterization of a novel diabetes-associated autoantigen.

, 1993
We have identified a novel 69-kD peptide autoantigen (ICA69) associated with insulin-dependent diabetes mellitus (IDDM) by screening a human islet lambda gt11 cDNA expression library with cytoplasmic islet cell antibody positive sera from relatives of
Babu, S, Castano, L, Prochazka, M, Leiter, E H, Naggert, J, Buelow, R, Pietropaolo, M   +6 more
core  

Commensal orthologs of the human autoantigen Ro60 as triggers of autoimmunity in lupus

, 2018
Commensal bacterial orthologs of the human autoantigen Ro60 may trigger cross-reactive T and B cells that initiate and sustain chronic autoimmunity in lupus.
Andrew L. Goodman, Sandra L. Wolin, Kevin Hughes, Michael Girardi, Stephen C. Renfroe, Soyeong Sim, Xinguo Chen, Marco Boccitto, Christina Kriegel, Carina Dehner, Julia Glanternik, Silvio M. Vieira, Teri M. Greiling, Karen H. Costenbader, Martin A. Kriegel, Daniel Zegarra Ruiz, Alonso J. Iñiguez, Xindi Chen, Patrick Degnan, William E. Ruff   +19 more
core   +1 more source

Bullous pemphigoid and mucous membrane pemphigoid humoral responses differ in reactivity towards BP180 midportion and BP230

Frontiers in Immunology
BackgroundBullous pemphigoid (BP) and mucous membrane pemphigoid (MMP) are rare autoimmune blistering disorders characterized by autoantibodies (autoAbs) targeting dermo-epidermal junction components such as BP180 and BP230.
Feliciana Mariotti, Anna Pira, Naomi De Luca, Anna Rita Giampetruzzi, Filomena Russo, Amilcare Cerri, Giulia Gasparini, Giulia Gasparini, Emanuele Cozzani, Emanuele Cozzani, Angelo V. Marzano, Angelo V. Marzano, Emiliano Antiga, Marzia Caproni, Pietro Quaglino, Marco Carrozzo, Biagio Didona, Giovanni Di Zenzo   +17 more
doaj   +1 more source

Activation of interferon regulatory factor-3 via toll-like receptor 3 and immunomodulatory functions detected in A549 lung epithelial cells exposed to misplaced U1-snRNA

, 2009
U1-snRNA is an integral part of the U1 ribonucleoprotein pivotal for pre-mRNA splicing. Toll-like receptor (TLR) signaling has recently been associated with immunoregulatory capacities of U1-snRNA.
Pfeilschifter, Josef (Prof. Dr.), Sadik, Christian David, Bachmann, Malte, Mühl, Heiko   +3 more
core   +1 more source