Results 121 to 130 of about 32,508 (252)

Islet cell autoantigen 69 kD (ICA69). Molecular cloning and characterization of a novel diabetes-associated autoantigen.

, 1993
We have identified a novel 69-kD peptide autoantigen (ICA69) associated with insulin-dependent diabetes mellitus (IDDM) by screening a human islet lambda gt11 cDNA expression library with cytoplasmic islet cell antibody positive sera from relatives of
Babu, S, Castano, L, Prochazka, M, Leiter, E H, Naggert, J, Buelow, R, Pietropaolo, M   +6 more
core   +1 more source

PSC‐DM: A Validated Clinical Diagnostic Model for Distinguishing Primary From Secondary Sclerosing Cholangitis

Liver International, Volume 46, Issue 11, November 2026.
ABSTRACT Background and Aims Primary sclerosing cholangitis (PSC) is a rare, progressive cholangiopathy for which diagnosis remains challenging because of the absence of disease‐specific markers and the presence of secondary causes of sclerosing cholangitis (SSC) that closely mimic its clinical presentation. Diagnostic uncertainty can delay appropriate
Miki Scaravaglio, Rodrigo V. Motta, Laura Cristoferi, Cesare Maino, Alberto Marini, Eugenia Nofit, Eugenia Pesatori, Camilla Gallo, Francesca Bolis, Daphne D'Amato, Armando Curto, Federica Malinverno, Alessio Gerussi, Raffaella Viganò, Mauro Viganò, Stephen J. Rossi, Kris V. Kowdley, Pietro Invernizzi, Alessandra Nardi, Marco Carbone, Emma L. Culver   +20 more
wiley   +1 more source

From Marginal to Central: Marginal Zone‐like B Cells as Critical Targets in Cladribine‐Treated Multiple Sclerosis

Annals of Neurology, Volume 100, Issue 4, Page 808-823, October 2026.
Objective Multiple sclerosis (MS) is a chronic autoimmune disease where B cells play a central pathogenic role. Cladribine, an oral therapy, provides durable benefits by reshaping lymphocyte populations, yet its specific long‐term impact on distinct B‐cell subsets is not fully understood.
Marta Pirronello, Mario Picozza, Gisella Guerrera, Silvia Corbisiero, Andrea Misiti, Roberta C. Placido, Alice Verdiani, Lorenzo de Marco, Manolo Sambucci, Elena Olivieri, Daniela F. Angelini, Esmeralda Quartuccio, Luca Prosperini, Carla Tortorella, Maria C. Buscarinu, Valeria Zancan, Francesca de Masi, Marco Salvetti, Claudio Gasperini, Giovanna Borsellino, Luca Battistini   +20 more
wiley   +1 more source

Cathepsin S dominates autoantigen processing in human thymic dendritic cells

, 2012
The interaction of developing thymocytes with peptide-MHC complexes on thymic antigen presenting cells (APC) is crucial for T cell development, both for positive selection of "useful" thymocytes as well as negative selection of autoreactive thymocytes to
Reich, Michael, Kalbacher, Hubert, Thomas Rückrich, Tolosa, Eva, Michael Reich, Arthur Melms, Stoeckle, Christina, Hubert Kalbacher, Timo Burster, Eva Tolosa, Driessen, Christoph, Christoph Driessen, Stöckle, Christina, Paula Quecke, Melms, Arthur, Quecke, Paula, Burster, Timo, Weber, Ekkehard, Christina Stoeckle, Rückrich, Thomas, Ekkehard Weber   +20 more
core   +1 more source

Anti‐Carbamylated Protein Antibodies Stabilize Carbamylated Histone H3 to Promote Synovial Activation and Neutrophil Extracellular Trap‐Mediated Bone Loss in Rheumatoid Arthritis

Arthritis &Rheumatology, Volume 78, Issue 10, Page 2074-2081, October 2026.
Objective Carbamylation, a nonenzymatic post‐translational modification, contributes to rheumatoid arthritis (RA) pathogenesis. Anti‐carbamylated protein antibodies (anti‐CarP) occur in around 50% of patients with RA and associate with greater joint damage. Neutrophil extracellular traps (NETs) are a major source of carbamylated autoantigens. We sought
Shuichiro Nakabo, Norio Hanata, Eduardo Patino‐Martinez, Ronald Holewinski, Ana Barrera‐Vargas, Javier Merayo‐Chalico, Scott A. Coonrod, David A. Fox, Mariana J. Kaplan, Carmelo Carmona‐Rivera   +9 more
wiley   +1 more source

Establishment of a Keratin 14/17-Induced Antigen-Specific Psoriasis-like Mouse Model

Biology
Psoriasis is a chronic inflammatory autoimmune skin disease significantly impairing the patients’ quality of life. Keratin (K)14 and K17 are abnormally expressed in psoriasis patients and considered to be potential autoantigens triggering this disease ...
Lanying Wang, Yulu Tang, Wenjing Li, Pengcheng Zhu, Wenjing Jia, Hao Liu, Yuanfang Ma, Guimei Wang, Ruiling Liu, Qingguo Ruan, Shijun J. Zheng   +10 more
doaj   +1 more source

Immune cells in the pathogenesis of abdominal aortic aneurysm: Roles, regulation and targeted interventions

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
This review provides a comprehensive overview of how macrophages, neutrophils, T cells and other immune cells infiltrate the aortic wall, undergo phenotypic shifts and interact with one another in abdominal aortic aneurysm (AAA). Background Abdominal aortic aneurysm (AAA) is a lethal degenerative vascular disease with no approved clinical drugs. Immune
Junqi Peng, Hanqing Zhang, Yun Wu, Song Chen   +3 more
wiley   +1 more source

Regulatory T cells in autoimmune diseases: biological mechanisms, clinical translation, and translational challenges

Frontiers in Immunology
Autoimmune diseases (ADs) are a group of inflammatory disorders triggered by aberrant immune responses against autoantigens and the breakdown of immune tolerance.
Jingchang Li, Jingchang Li, Jia Pang, Jia Pang, Peipei Wu, Enmei Wang, Enmei Wang, Shijun J. Zheng, Shijun J. Zheng, Qingguo Ruan, Qingguo Ruan, Ruiling Liu, Ruiling Liu   +12 more
doaj   +1 more source

Markers of Systemic Metabolic Dysfunction in Vitiligo and Their Potential Role in Disease Pathogenesis: A Narrative Review

Health Science Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Vitiligo is a chronic autoimmune disease characterized by the progressive destruction of melanocytes, resulting in depigmented skin macules. While traditionally viewed as a cutaneous disorder driven by a specific CD8+ T cell‐mediated interferon‐γ (IFN‐γ) signature, emerging research suggests that vitiligo may be a systemic condition
Federica Papaccio, Simona Scano, Barbara Bellei   +2 more
wiley   +1 more source

Acute Neurological Manifestations in COVID‐19 Are Associated With Complement Activation and Glia‐Promoted Neuroinflammation

Journal of Medical Virology, Volume 98, Issue 10, October 2026.
ABSTRACT Pathophysiological mechanisms of neurological manifestations in COVID‐19 are not fully known yet. In this case‐control study, proteomic analysis was used to characterize cerebrospinal fluid (CSF) samples from COVID‐19 patients with acute neurological manifestations primarily categorized as: isolated refractory headache (n = 12), encephalopathy
Nicole Lardini Freitas, Yago Côrtes Pinheiro Gomes, Fábio César Sousa Nogueira, Juliana Echevarria‐Lima, João Victor Carvalho Deus, Carlos Otávio Brandão, Cristiane Nascimento Soares, Marcus Tulius Teixeira Silva, Otávio Melo Espíndola   +8 more
wiley   +1 more source