Results 1 to 10 of about 16,490 (139)
Discover Oncology, 2023 Objective To explore the DPP4 expression changes and functions in ovarian cancer (OV), as well as the regulation mechanism for DDP4. Methods GEPIA2, GSE18520, GSE26712 and UALCAN were used to analyze differences in DPP4 expression between OV tumors and ...
Zhao-Wei Gao, Xia-Nan Wu, Ke Dong
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DPP4 as a Potential Candidate in Cardiovascular Disease
Journal of Inflammation Research, 2022 Si-Yu Chen,1,* Xiang-Quan Kong,1,2,* Ke-Fan Zhang,3,* Shuai Luo,1 Feng Wang,1 Jun-Jie Zhang1,2 1Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, People’s Republic of China; 2Department of Cardiology ...
Jun-Jie Zhang
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Frontiers in Endocrinology, 2019 Background: Increase in circulating dipeptidyl peptidase-4 (DPP4) activity and levels has been reported to associate both with hyperglycemia and obesity.
Jit Sarkar, Titli Nargis, Sujoy Ghosh
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Frontiers in Immunology, 2015 Dipeptidyl peptidase 4 (DPP4) is a glycoprotein of 110 kDa, which is ubiquitously expressed on the surface of a variety of cells. This exopeptidase selectively cleaves N-terminal dipeptides from a variety of substrates, including cytokines, growth ...
Jürgen Eckel
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Molecules, 2020 Proteases catalyse irreversible posttranslational modifications that often alter a biological function of the substrate. The protease dipeptidyl peptidase 4 (DPP4) is a pharmacological target in type 2 diabetes therapy primarily because it inactivates ...
Cecy R Xi +2 more
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Identification and validation of DPP4 in predicting the prognosis of clear cell RCC [PDF]
Discover OncologyDipeptidyl peptidase-4 (DPP4) has been implicated in tumor progression, yet its role in clear cell renal cell carcinoma (KIRC) remains poorly understood. This study aimed to comprehensively investigate the expression profile, prognostic significance, and
Min Luo, Peifeng Li
doaj +2 more sources
Prognostic and Therapeutic Significance of DPP4 in SMARCA4-Deficient Non–Small Cell Lung Cancer [PDF]
Technology in Cancer Research & TreatmentIntroduction SMARCA4-deficient NSCLC is an aggressive subtype lacking robust biomarkers and therapeutic targets. To define the expression pattern and clinical significance of DPP4 in SMARCA4-dNSCLC and explore whether DPP4 may represent a therapeutic ...
Chaopeng Chen +8 more
doaj +2 more sources
Elevated hepatic DPP4 activity promotes insulin resistance and non-alcoholic fatty liver disease
Molecular Metabolism, 2017 Objective: Increased hepatic expression of dipeptidyl peptidase 4 (DPP4) is associated with non-alcoholic fatty liver disease (NAFLD). Whether this is causative for the development of NAFLD is not yet clarified.
Christian Baumeier +2 more
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KLK5 induces shedding of DPP4 from circulatory Th17 cells in type 2 diabetes
Molecular Metabolism, 2017 Objective: Increasing plasma levels and activity of dipeptidyl peptidase-4 (DPP4 or CD26) are associated with rapid progression of metabolic syndrome to overt type 2 diabetes mellitus (T2DM).
Titli Nargis +2 more
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Dual-source DPP4 drives intestinal fibrosis in Crohn’s disease: synergistic therapeutic targeting of host and microbiota pathways [PDF]
Gut MicrobesCrohn’s disease (CD), a chronic inflammatory bowel disorder, often progresses to intestinal fibrosis and stricture, yet no effective anti-fibrotic treatments exist.
Jiajia Li +6 more
doaj +2 more sources