Results 1 to 10 of about 19,701 (225)
Frontiers in Immunology, 2015 Dipeptidyl peptidase 4 (DPP4) is a glycoprotein of 110 kDa, which is ubiquitously expressed on the surface of a variety of cells. This exopeptidase selectively cleaves N-terminal dipeptides from a variety of substrates, including cytokines, growth ...
Jürgen Eckel
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A Novel Purification Procedure for Active Recombinant Human DPP4 and the Inability of DPP4 to Bind SARS-CoV-2 [PDF]
Molecules, 2020 Proteases catalyse irreversible posttranslational modifications that often alter a biological function of the substrate. The protease dipeptidyl peptidase 4 (DPP4) is a pharmacological target in type 2 diabetes therapy primarily because it inactivates ...
Joel Mackay +2 more
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DPP4 as a Potential Candidate in Cardiovascular Disease
Journal of Inflammation Research, 2022 Si-Yu Chen,1,* Xiang-Quan Kong,1,2,* Ke-Fan Zhang,3,* Shuai Luo,1 Feng Wang,1 Jun-Jie Zhang1,2 1Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, People’s Republic of China; 2Department of Cardiology ...
Jun-Jie Zhang
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CD26/DPP4 - a potential biomarker and target for cancer therapy [PDF]
Pharmacology & Therapeutics, 2019 CD26/dipeptidyl peptidase (DPP)4 is a membrane-bound protein found in many cell types of the body, and a soluble form is present in body fluids. There is longstanding evidence that various primary tumors and also metastases express CD26/DPP4 to a variable extent. By cleaving dipeptides from peptides with a proline or alanine in the penultimate position
Gwendolyn Vliegen +2 more
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Elevated hepatic DPP4 activity promotes insulin resistance and non-alcoholic fatty liver disease
Molecular Metabolism, 2017 Objective: Increased hepatic expression of dipeptidyl peptidase 4 (DPP4) is associated with non-alcoholic fatty liver disease (NAFLD). Whether this is causative for the development of NAFLD is not yet clarified.
Norbert Stefan +2 more
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The Roles of Dipeptidyl Peptidase 4 (DPP4) and DPP4 Inhibitors in Different Lung Diseases: New Evidence [PDF]
Frontiers in Pharmacology, 2021 CD26/Dipeptidyl peptidase 4 (DPP4) is a type II transmembrane glycoprotein that is widely expressed in various organs and cells. It can also exist in body fluids in a soluble form. DPP4 participates in various physiological and pathological processes by regulating energy metabolism, inflammation, and immune function.
Hong Fan, Dongguang Wang
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DPP4 Activity, Hyperinsulinemia, and Atherosclerosis
Journal of Clinical Endocrinology and Metabolism, 2021 Abstract Context Obesity and type 2 diabetes are associated with chronic hyperinsulinemia, elevated plasma levels of dipeptidyl peptidase-4 (DPP4), and a pro-atherosclerotic milieu. Evidence Acquisition PubMed search of the term ...
Zhenqi Liu, Kaitlin Love
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Significance of circulatory DPP4 activity in metabolic diseases [PDF]
IUBMB Life, 2018 AbstractDipeptidyl peptidase 4 (DPP4), also known as CD26 is a type II transmembrane protein that is released from the cell membrane in a nonclassical secretory mechanism. This exopeptidase selectively degrades varieties of substrates including incretin hormones, growth factors, and cytokines.
Partha Chakrabarti, Titli Nargis
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Identification and validation of DPP4 in predicting the prognosis of clear cell RCC [PDF]
Discover OncologyDipeptidyl peptidase-4 (DPP4) has been implicated in tumor progression, yet its role in clear cell renal cell carcinoma (KIRC) remains poorly understood. This study aimed to comprehensively investigate the expression profile, prognostic significance, and
Min Luo, Peifeng Li
doaj +2 more sources
KLK5 induces shedding of DPP4 from circulatory Th17 cells in type 2 diabetes
Molecular Metabolism, 2017 Objective: Increasing plasma levels and activity of dipeptidyl peptidase-4 (DPP4 or CD26) are associated with rapid progression of metabolic syndrome to overt type 2 diabetes mellitus (T2DM).
Krishna Kumar +2 more
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