Results 41 to 50 of about 19,701 (225)

DPP4 activity in plasma.

, 2020
A and B: DPP4 activity in plasma from patients with AAA compared with age-matched controls; with diabetic patients and controls included (A) and excluded (B). C: DPP4 activity in the thrombus-covered wall.
Moritz Lindquist Liljeqvist (4576801), Malin Kronqvist (6822239), Joy Roy (3439511), Christina Villard (8350929), Mariette Lengquist (571206), Rebecka Hultgren (6743690), Linnea Eriksson (8350926)   +6 more
core   +1 more source

Ramachandran plots of DPP4 structure upon mutagenesis using MolProbity web server.

, 2021
(a) DPP4-WT, (b) DPP4-N229I, (c) DPP4-K267N, (d) DPP4-K267E, (e) DPP4-T288P, (f) DPP4-L294V and (g) DPP4-I295L. (TIF)
Latifa Anga (11565427), Jalal Nourlil (3159525), Abdellah Faouzi (238666), Anass Abbad (11565424), Nadia Iounes (11565430)   +4 more
core   +1 more source

Increased Plasma Dipeptidyl Peptidase-4 (DPP4) Activity Is an Obesity-Independent Parameter for Glycemic Deregulation in Type 2 Diabetes Patients

Frontiers in Endocrinology, 2019
Background: Increase in circulating dipeptidyl peptidase-4 (DPP4) activity and levels has been reported to associate both with hyperglycemia and obesity.
Jit Sarkar, Jit Sarkar, Jit Sarkar, Titli Nargis, Om Tantia, Sujoy Ghosh, Partha Chakrabarti, Partha Chakrabarti   +7 more
doaj   +1 more source

Plasma levels of DPP4 activity and sDPP4 are dissociated from inflammation in mice and humans

Nature Communications, 2020
DPP4 inhibitors are used for the treatment of diabetes, but the impact of DPP4 activity and soluble DPP4 on development of diabetes-associated inflammation remains uncertain.
Laurie L. Baggio, Elodie M. Varin, Jacqueline A. Koehler, Xiemin Cao, Yuliya Lokhnygina, Susanna R. Stevens, Rury R. Holman, Daniel J. Drucker   +7 more
doaj   +1 more source

High mobility group box 1 contributes to wound healing induced by inhibition of dipeptidylpeptidase 4 in cultured keratinocytes

Frontiers in Pharmacology, 2015
Dipeptidyl peptidase 4 (DPP4) is expressed in various tissues, including the skin, and DPP4 inhibitors, that are currently used for the treatment of diabetes, may be effective also for complications of diabetes that affect the skin. To assess the role of
Tiziana eSinagra, Sara eMerlo, Simona Federica Spampinato, Rocco eDe Pasquale, Maria Angela eSortino   +4 more
doaj   +1 more source

Hepatocyte-derived DPP4 regulates portal GLP-1 bioactivity, modulates glucose production, and when absent influences NAFLD progression

JCI Insight, 2023
Elevated circulating dipeptidyl peptidase-4 (DPP4) is a biomarker for liver disease, but its involvement in gluconeogenesis and metabolic associated fatty liver disease progression remains unclear. Here, we identified that DPP4 in hepatocytes but not TEK
Natasha A. Trzaskalski, Branka Vulesevic, My-Anh Nguyen, Natasha Jeraj, Evgenia Fadzeyeva, Nadya M. Morrow, Cassandra A.A. Locatelli, Nicole Travis, Antonio A. Hanson, Julia R.C. Nunes, Conor O’Dwyer, Jelske N. van der Veen, Ilka Lorenzen-Schmidt, Rick Seymour, Serena M. Pulente, Andrew C. Clément, Angela M. Crawley, René L. Jacobs, Mary-Anne Doyle, Curtis L. Cooper, Kyoung-Han Kim, Morgan D. Fullerton, Erin E. Mulvihill   +22 more
doaj   +1 more source

Saxagliptin Cardiotoxicity in Chronic Heart Failure: The Role of DPP4 in the Regulation of Neuropeptide Tone

Biomedicines, 2022
Dipeptidyl-peptidase-4 (DPP4) inhibitors are novel medicines for diabetes. The SAVOR-TIMI-53 clinical trial revealed increased heart-failure-associated hospitalization in saxagliptin-treated patients. Although this side effect could limit therapeutic use,
Imre Vörös, Zsófia Onódi, Viktória Éva Tóth, Tamás G. Gergely, Éva Sághy, Anikó Görbe, Ágnes Kemény, Przemyslaw Leszek, Zsuzsanna Helyes, Péter Ferdinandy, Zoltán V. Varga   +10 more
doaj   +1 more source

DPP4 expression in normal aorta and AAA.

, 2020
A: Normal DPP4 gene expression in different tissues, data from the genotype-tissue expression (GTEx) database, in which genome-wide gene expression is available from different disease-free tissues of hundreds of human donors.
Moritz Lindquist Liljeqvist (4576801), Malin Kronqvist (6822239), Joy Roy (3439511), Christina Villard (8350929), Mariette Lengquist (571206), Rebecka Hultgren (6743690), Linnea Eriksson (8350926)   +6 more
core   +1 more source

Exploring structural dynamics of the MERS-CoV receptor DPP4 and mutant DPP4 receptors

Journal of Biomolecular Structure and Dynamics, 2020
Mouse DPP4 (mDPP4) receptor is not a functional receptor for MERS-CoV while human DPP4 (hDPP4) is, despite the high similarities between hDPP4 and mDPP4 receptors. The variability of DPP4 receptors against MERS-CoV is not fully investigated, especially conformational and structural differences. Therefore, investigating the conformational differences of
openaire   +2 more sources

Dipeptidyl peptidase 4 expression is not associated with an activated fibroblast phenotype in idiopathic pulmonary fibrosis

Frontiers in Pharmacology, 2022
Dipeptidyl peptidase 4 (DPP4) has been proposed as a marker for activated fibroblasts in fibrotic disease. We aimed to investigate whether a profibrotic DPP4 phenotype is present in lung tissue from patients with idiopathic pulmonary fibrosis (IPF).
Måns Kadefors, Frida Berlin, Marie Wildt, Göran Dellgren, Sara Rolandsson Enes, Anders Aspberg, Gunilla Westergren-Thorsson   +6 more
doaj   +1 more source