Results 21 to 30 of about 19,701 (225)

Glucose metabolism disorders associated with COVID-19: clinical and morphological study

Сахарный диабет, 2023
BACKGROUND. Glucose metabolism disorders (GMD) were detected both in acute and in post-COVID, however, its pathogenic aspects remain unclear.AIM. To analyze the occurrence of GMD in post-COVID patients who have had moderate and severe COVID-19 without ...
T. L. Karonova, A. A. Mikhailova, D. I. Lagutina, O. M. Vorobeva, D. O. Grigoreva, K. A. Sterkhova, V. A. Malko, A. G. Mikheeva, A. T. Chernikova, L. B. Mitrofanova, E. V. Shlyakhto   +10 more
doaj   +1 more source

DPP4 Regulates the Th17/IL-17 Axis and Accelerates Epithelial Mesenchymal Transition to Promote Ovalbumin-Induced Asthma in Female C57BL/6J Mice

Frontiers in Bioscience-Landmark, 2023
Background: Dipeptidyl peptidase-4 (DPP4) is a transmembrane glycoprotein, prevalent across a variety of tissues and cells and can be foundin a solubilised in peripheral blood.
Linqiao Li, Feixiang Ling, Rou Li, Yan Jiang, Haiyan Long, Bo Xiao, Jingjie Wu, Zhiheng Long, Libing Ma   +8 more
doaj   +1 more source

DPP4-Truncated CXCL12 Alters CXCR4/ACKR3 Signaling, Osteogenic Cell Differentiation, Migration, and Senescence

, 2022
Bone marrow skeletal stem cells (SSCs) secrete many cytokines including stromal derived factor-1 or CXCL12, which influences cell proliferation, migration, and differentiation.
Xing-ming Shi (5651545), Alexandra Aguilar-Pérez (14254194), Maggie M. Calkins (14254191), Maribeth Johnson (282723), Meghan E. McGee-Lawrence (11145861), Michael B. Dwinell (8627076), William D. Hill (14254206), Nada H. Eisa (14254182), Louis M. Luttrell (408469), Galina Kondrikova (14254188), Joe B. Blumer (14254203), Sudharsan Periyasamy-Thandavan (14254185), Dmitry Kondrikov (447343), Jie Chen (5892), Charles Reitman (14254197), John D. McCorvy (1416910), Ahmed M. Elmansi (14254179), Kyler S. Crawford (14254200), Brian F. Volkman (502457)   +18 more
core   +2 more sources

Reduced humidity induces skin barrier dysfunction and secretion of dipeptidyl peptidase-4 (DPP-4) in a skin-equivalent model [PDF]

Archives of Biological Sciences, 2019
Seasonal changes can affect the physiological condition of the skin and cause various cutaneous disorders. The skin barrier function tends to worsen during winter when humidity is lower compared to other seasons.
Lee Sung Hoon, Bae Il-Hong, Marinho Paulo A., Lee Chang Seok, Lee Jongsung   +4 more
doaj   +1 more source

Molecular Docking of Compounds in Moringa oleifera Lam with Dipeptidyl Peptidase-4 Receptors as Antidiabetic Candidates

Jurnal Farmasi dan Ilmu Kefarmasian Indonesia, 2021
Background: Diabetes mellitus (DM) type 2 is a metabolic disorder that needs special attention because it can damage several organs if the severity increases. One of the treatments for diabetes mellitus (DM) type 2 is by inhibiting Dipeptidyl peptidase 4
Indah Permata Rendi, Gabriella Josephine Maranata, Hasna Chaerunisa, Nurulita Nugrahaeni, Siti Sarah Alfathonah   +4 more
doaj   +1 more source

Sitagliptin: a potential drug for the treatment of COVID-19?

Acta Pharmaceutica, 2021
Recently, an outbreak of a fatal coronavirus, SARS-CoV-2, has emerged from China and is rapidly spreading worldwide. Possible interaction of SARS-CoV-2 with DPP4 peptidase may partly contribute to the viral pathogenesis.
Bardaweel Sanaa K., Hajjo Rima, Sabbah Dima A.   +2 more
doaj   +1 more source

DPP4 in Cardiometabolic Disease [PDF]

Circulation Research, 2015
The discovery of incretin-based medications represents a major therapeutic advance in the pharmacological management of type 2 diabetes mellitus (T2DM), as these agents avoid hypoglycemia, weight gain, and simplify the management of T2DM. Dipeptidyl peptidase-4 (CD26, DPP4) inhibitors are the most widely used incretin-based therapy for the treatment of
Jixin, Zhong, Andrei, Maiseyeu, Stephen N, Davis, Sanjay, Rajagopalan   +3 more
openaire   +2 more sources

Down-regulation of DPP4 by TGFβ1/miR29a-3p inhibited proliferation and promoted migration of ovarian cancer cells

Discover Oncology, 2023
Objective To explore the DPP4 expression changes and functions in ovarian cancer (OV), as well as the regulation mechanism for DDP4. Methods GEPIA2, GSE18520, GSE26712 and UALCAN were used to analyze differences in DPP4 expression between OV tumors and ...
Chong Liu, Zhao-Wei Gao, Ying-Qi Liu, Lan Yang, Xia-Nan Wu, Ke Dong, Xiao-Ming Zhu   +6 more
doaj   +1 more source

Emerging Role of Dipeptidyl Peptidase-4 in Autoimmune Disease

Frontiers in Immunology, 2022
Dipeptidyl-peptidase IV (DPP4), originally identified as an aminopeptidase in 1960s, is an ubiquitously expressed protease presented as either a membrane-bound or soluble form.
Jie Huang, Xinxin Liu, Yingying Wei, Xinlu Li, Shupei Gao, Lingli Dong, Xiaoquan Rao, Jixin Zhong   +7 more
doaj   +1 more source

DPP4 Is a Potential Prognostic Marker of Thyroid Carcinoma and a Target for Immunotherapy

International Journal of Endocrinology, 2022
DPP4 (dipeptidyl peptidase 4) is expressed in many cancers, but the relationship between DPP4 and thyroid carcinoma (THCA) is incompletely understood. We aim to explore the expression of DPP4 in THCA and the correlation between DPP4 expression with the ...
Xiaoqian Gao, Yali Le, Chenchen Geng, Zhen Jiang, Guanghui Zhao, Ping Zhang   +5 more
doaj   +1 more source