Results 21 to 30 of about 16,540 (179)

Unraveling DPP4 Receptor Interactions with SARS-CoV-2 Variants and MERS-CoV: Insights into Pulmonary Disorders via Immunoinformatics and Molecular Dynamics

Viruses, 2023
Human coronaviruses like MERS CoV are known to utilize dipeptidyl peptidase 4 (DPP4), apart from angiotensin-converting enzyme 2(ACE2) as a potential co-receptor for viral cell entry.
Arpan Narayan Roy, Aayatti Mallick Gupta, Deboshmita Banerjee, Jaydeb Chakrabarti, Pongali B. Raghavendra   +4 more
doaj   +1 more source

The role of dipeptidyl peptidase 4 (DPP4) in the preservation of renal function: DPP4 involvement in hemoglobin expression [PDF]

Journal of Endocrinology, 2014
In a previous study, we demonstrated that dipeptidyl peptidase 4 (DPP4)-deficient rats were susceptible to reduced glomerular filtration rate as a result of streptozotocin (STZ)-induced diabetes. Therefore, we proposed that DPP4 might be responsible for the preservation of renal function. In this study, to verify the role of DPP4 in the preservation of
Youichi, Sato, Takanobu, Kamada, Aiko, Yamauchi   +2 more
openaire   +2 more sources

Dysregulation of DPP4-CXCL12 Balance by TGF-β1/SMAD Pathway Promotes CXCR4+ Inflammatory Cell Infiltration in Keloid Scars

Journal of Inflammation Research, 2021
ZongAn Chen,1,* Zhen Gao,1,* LingLing Xia,1 XiaoQing Wang,2,* LiMing Lu,3,* XiaoLi Wu1,* 1Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai ...
Chen Z, Gao Z, Xia L, Wang X, Lu L, Wu X
doaj  

Potency, selectivity and prolonged binding of saxagliptin to DPP4: maintenance of DPP4 inhibition by saxagliptin in vitro and ex vivo when compared to a rapidly-dissociating DPP4 inhibitor [PDF]

BMC Pharmacology, 2012
Abstract Background Dipeptidylpeptidase 4 (DPP4) inhibitors have clinical benefit in patients with type 2 diabetes mellitus by increasing levels of glucose-lowering incretin hormones, such as glucagon-like peptide -1 (GLP-1), a peptide with a short half life that is secreted for approximately 1 hour following a meal ...
Wang, Aiying, Dorso, Charles, Kopcho, Lisa, Locke, Gregory, Langish, Robert, Harstad, Eric, Shipkova, Petia, Marcinkeviciene, Jovita, Hamann, Lawrence, Kirby, Mark S   +9 more
openaire   +2 more sources

A Clinical Study on the Association of Sodium-Glucose Cotransporter 2 Inhibitors and Acute Kidney Injury Among Diabetic Chinese Population

Diabetes, Metabolic Syndrome and Obesity, 2021
Lianglan Shen,* Hongli Yang,* Xingxing Fang, Huaxing Huang, Wubin Yao, Dongmei Chen, Yan Shen Department of Nephrology, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu, 226001, People’s Republic of China*These authors ...
Shen L, Yang H, Fang X, Huang H, Yao W, Chen D, Shen Y   +6 more
doaj  

Dipeptidyl peptidase IV inhibitor-associated bullous pemphigoid: a recently recognized autoimmune blistering disease with unique clinical, immunological and genetic characteristics

Immunological Medicine, 2019
Bullous pemphigoid (BP) is an organ-specific autoantibody-mediated autoimmune blistering skin disorder that tends to affect the elderly. Tense blister formation associated with itchy urticarial erythema is clinically observed in BP, and subepidermal ...
Wataru Nishie
doaj   +1 more source

DPP4 inhibitors promote biological functions of human endothelial progenitor cells by targeting the SDF-1/CXCR4 signaling pathway [PDF]

Archives of Biological Sciences, 2016
Dipeptidyl peptidase 4 (DPP4) inhibitors(oral hypoglycemic agents)have beneficial effects during the early stages of diabetes. In this study, we evaluated the role of DPP4inhibitorsonthe biological functions of cultured human endothelial ...
Liu Feng, Huang Guo-Dong, Tang Jia-Zhen, Peng Yu-Huan   +3 more
doaj   +1 more source

The Multiple Biological Functions of Dipeptidyl Peptidase-4 in Bone Metabolism

Frontiers in Endocrinology, 2022
Dipeptidyl peptidase-4 (DPP4) is a ubiquitously occurring protease involved in various physiological and pathological processes ranging from glucose homeostasis, immunoregulation, inflammation to tumorigenesis.
Qiu Yang, Qiu Yang, Bing Fu, Dan Luo, Haibo Wang, Hongyi Cao, Xiang Chen, Li Tian, Xijie Yu   +8 more
doaj   +1 more source

Hepatocyte-derived DPP4 regulates portal GLP-1 bioactivity, modulates glucose production, and when absent influences NAFLD progression

JCI Insight, 2023
Elevated circulating dipeptidyl peptidase-4 (DPP4) is a biomarker for liver disease, but its involvement in gluconeogenesis and metabolic associated fatty liver disease progression remains unclear. Here, we identified that DPP4 in hepatocytes but not TEK
Natasha A. Trzaskalski, Branka Vulesevic, My-Anh Nguyen, Natasha Jeraj, Evgenia Fadzeyeva, Nadya M. Morrow, Cassandra A.A. Locatelli, Nicole Travis, Antonio A. Hanson, Julia R.C. Nunes, Conor O’Dwyer, Jelske N. van der Veen, Ilka Lorenzen-Schmidt, Rick Seymour, Serena M. Pulente, Andrew C. Clément, Angela M. Crawley, René L. Jacobs, Mary-Anne Doyle, Curtis L. Cooper, Kyoung-Han Kim, Morgan D. Fullerton, Erin E. Mulvihill   +22 more
doaj   +1 more source

High mobility group box 1 contributes to wound healing induced by inhibition of dipeptidylpeptidase 4 in cultured keratinocytes

Frontiers in Pharmacology, 2015
Dipeptidyl peptidase 4 (DPP4) is expressed in various tissues, including the skin, and DPP4 inhibitors, that are currently used for the treatment of diabetes, may be effective also for complications of diabetes that affect the skin. To assess the role of
Tiziana eSinagra, Sara eMerlo, Simona Federica Spampinato, Rocco eDe Pasquale, Maria Angela eSortino   +4 more
doaj   +1 more source