Boning up on DPP4, DPP4 substrates, and DPP4-adipokine interactions: Logical reasoning and known facts about bone related effects of DPP4 inhibitors [PDF]
Bone, 2016 Dipeptidyl peptidase 4 (DPP4) is a conserved exopeptidase with an important function in protein regulation. The activity of DPP4, an enzyme which can either be anchored to the plasma membrane or circulate free in the extracellular compartment, affects the glucose metabolism, cellular signaling, migration and differentiation, oxidative stress and the ...
Lorenzo Glorie +2 more
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DPP4 deficiency preserved cardiac function in abdominal aortic banding rats. [PDF]
PLoS ONE, 2014 Dipeptidyl peptidase-4 (DPP4) enzyme inhibition has been reported to increase plasma glucagon-like peptide-1 (GLP-1) level for controlling postprandial glucose concentration. A prominent GLP-1 level in DPP4-deficient rats contributed to the resistance of
Hui-Chun Ku, Ming-Jai Su
doaj +3 more sources
DPP4 (dipeptidyl-peptidase 4) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2013 Review on DPP4 (dipeptidyl-peptidase 4), with data on DNA, on the protein encoded, and where the gene is implicated.
Ohnuma, K, Morimoto, C
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DPP4 rs17574 polymorphism and elevated DPP4 levels linked to fatty liver in subclinical atherosclerosis: GEA study findings [PDF]
Biomolecules & BiomedicineDipeptidyl peptidase-4 (DPP4) concentrations are known to correlate with nonalcoholic fatty liver (FL), which is also associated with subclinical atherosclerosis (SA).
Gilberto Vargas-Alarcón +6 more
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A poor prognosis in human hepatocellular carcinoma is associated with low expression of DPP4 [PDF]
Brazilian Journal of Medical and Biological Research, 2020 This study aimed to explore the prognostic role of dipeptidyl peptidase 4 (DPP4) expression in hepatocellular carcinoma (HCC). DPP4 expression was measured in formalin-fixed paraffin-embedded specimens that were gathered from 327 HCC patients ...
Hao Yu +4 more
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Oxidized LDL upregulates macrophage DPP4 expression via TLR4/TRIF/CD36 pathwaysResearch in context
EBioMedicine, 2019 Background: We and others have shown that dipeptidyl peptidase-IV (DPP4) expression is increased in obesity/atherosclerosis and is positively correlated with atherosclerotic burden.
Xiaoquan Rao +9 more
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The regulatory role of DPP4 in atherosclerotic disease
Cardiovascular Diabetology, 2017 The increasing prevalence of atherosclerosis has become a worldwide health concern. Although significant progress has been made in the understanding of atherosclerosis pathogenesis, the underlying mechanisms are not fully understood. Recent studies suggest dipeptidyl peptidase-4 (DPP4), a regulator of inflammation and metabolism, may be involved in the
Lihua Duan +4 more
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Adaptive Evolution of MERS-CoV to Species Variation in DPP4 [PDF]
Cell Reports, 2018 (Uploaded by Plazi for the Bat Literature Project) Middle East Respiratory Syndrome Coronavirus (MERS-CoV) likely originated in bats and passed to humans through dromedary camels; however, the genetic mechanisms underlying cross-species adaptation remain poorly understood.
Michael Letko +8 more
core +8 more sources
Low DPP4 expression and activity in multiple sclerosis
Clinical Immunology, 2014 Multiple sclerosis (MS) is a prototypic Th1/Th17 chronic autoimmune disease of the central nervous system. Dipeptidyl peptidase 4 (DPP4 or CD26) is a multifunctional molecule involved in autoimmune diseases' pathophysiology. We sought to integrate disparate pieces of data and analyze the plasma levels of sDPP4, DPP activity and DPP4 surface expression ...
Tejera-Alhambra, Marta +7 more
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Association of DPP4 with esophageal stricture progression and the Hippo-YAP pathway. [PDF]
Animal Model Exp MedThis study establishes a comprehensive translational platform for esophageal stricture (ES) research by integrating a novel rat model with clinically relevant porcine validation. This study identifies DPP4 as a gene of interest associated with ES following endoscopic submucosal dissection, demonstrating that prophylactic DPP4 inhibition attenuates ...
Wu R +5 more
europepmc +2 more sources