Viruses, 2023 Human coronaviruses like MERS CoV are known to utilize dipeptidyl peptidase 4 (DPP4), apart from angiotensin-converting enzyme 2(ACE2) as a potential co-receptor for viral cell entry.
Arpan Narayan Roy +4 more
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The role of dipeptidyl peptidase 4 (DPP4) in the preservation of renal function: DPP4 involvement in hemoglobin expression [PDF]
Journal of Endocrinology, 2014 In a previous study, we demonstrated that dipeptidyl peptidase 4 (DPP4)-deficient rats were susceptible to reduced glomerular filtration rate as a result of streptozotocin (STZ)-induced diabetes. Therefore, we proposed that DPP4 might be responsible for the preservation of renal function.
Youichi, Sato +2 more
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Journal of Inflammation Research, 2021 ZongAn Chen,1,* Zhen Gao,1,* LingLing Xia,1 XiaoQing Wang,2,* LiMing Lu,3,* XiaoLi Wu1,* 1Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai ...
Chen Z, Gao Z, Xia L, Wang X, Lu L, Wu X
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بررسی اثر انواع تمرینات مقاومتی، استقامتی پیوسته و تناوبی بر سطوح DPP4 و NRG1 در زنان دارای اضافه وزن [PDF]
Majallah-i Dānishkadah-i Pizishkī-i Dānishgāh-i ̒ Ulūm-i Pizishkī-i Mashhad.مقدمه: اضافه وزن و چاقی از مشکلات عمده بهداشتی در جهان ماشینی و کم تحرک امروزی به حساب می آید که سلامت قشر وسیعی از جوامع را تهدید می کند. هدف از این پژوهش بررسی تاثیر هشت هفته تمرینات مقاومتی ، استقامتی پیوسته و اینتروال بر شاخصهای DPP4 و NRG1 در زنان ...
لیلا نوری آئین +4 more
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Integrative In Silico Profiling of Major Phytochemicals From a Sclerocarya birrea-Nauclea latifolia-Piper longum Mixture: Docking, Molecular Dynamics, ADMET, and Ligand-Based Target Prediction on Shared Pathways in Type 2 Diabetes Mellitus and Alzheimer's Disease. [PDF]
ChemistryOpenWhich major phytochemical from the Sclerocarya birrea–Nauclea latifolia–Piper longum mixture engages shared targets across the T2DM–AD axis? Integrated docking, triplicate 100‐ns molecular dynamics, post‐MD MM‐GBSA, and ADMET/target prediction prioritize QR‐PME, which forms stable GSK3β and TACE complexes with binding energy estimates comparable to ...
Tientcheu JPD, İstifli ES.
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Potency, selectivity and prolonged binding of saxagliptin to DPP4: maintenance of DPP4 inhibition by saxagliptin in vitro and ex vivo when compared to a rapidly-dissociating DPP4 inhibitor [PDF]
BMC Pharmacology, 2012 Abstract Background Dipeptidylpeptidase 4 (DPP4) inhibitors have clinical benefit in patients with type 2 diabetes mellitus by increasing levels of glucose-lowering incretin hormones, such as glucagon-like peptide -1 (GLP-1), a peptide with a short half life that is secreted for approximately 1 hour following a meal ...
Wang, Aiying +9 more
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Diabetes, Metabolic Syndrome and Obesity, 2021 Lianglan Shen,* Hongli Yang,* Xingxing Fang, Huaxing Huang, Wubin Yao, Dongmei Chen, Yan Shen Department of Nephrology, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu, 226001, People’s Republic of China*These authors ...
Shen L +6 more
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The Multiple Biological Functions of Dipeptidyl Peptidase-4 in Bone Metabolism
Frontiers in Endocrinology, 2022 Dipeptidyl peptidase-4 (DPP4) is a ubiquitously occurring protease involved in various physiological and pathological processes ranging from glucose homeostasis, immunoregulation, inflammation to tumorigenesis.
Qiu Yang +8 more
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Immunological Medicine, 2019 Bullous pemphigoid (BP) is an organ-specific autoantibody-mediated autoimmune blistering skin disorder that tends to affect the elderly. Tense blister formation associated with itchy urticarial erythema is clinically observed in BP, and subepidermal ...
Wataru Nishie
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DPP4 inhibitors promote biological functions of human endothelial progenitor cells by targeting the SDF-1/CXCR4 signaling pathway [PDF]
Archives of Biological Sciences, 2016 Dipeptidyl peptidase 4 (DPP4) inhibitors(oral hypoglycemic agents)have beneficial effects during the early stages of diabetes. In this study, we evaluated the role of DPP4inhibitorsonthe biological functions of cultured human endothelial ...
Liu Feng +3 more
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