Results 31 to 40 of about 16,540 (179)
DPP4 deficiency preserved cardiac function in abdominal aortic banding rats. [PDF]
PLoS ONE, 2014 Dipeptidyl peptidase-4 (DPP4) enzyme inhibition has been reported to increase plasma glucagon-like peptide-1 (GLP-1) level for controlling postprandial glucose concentration. A prominent GLP-1 level in DPP4-deficient rats contributed to the resistance of
Hui-Chun Ku, Ming-Jai Su
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DPP4 (dipeptidyl-peptidase 4) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2013 Review on DPP4 (dipeptidyl-peptidase 4), with data on DNA, on the protein encoded, and where the gene is implicated.
Ohnuma, K, Morimoto, C
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Plasma levels of DPP4 activity and sDPP4 are dissociated from inflammation in mice and humans
Nature Communications, 2020 DPP4 inhibitors are used for the treatment of diabetes, but the impact of DPP4 activity and soluble DPP4 on development of diabetes-associated inflammation remains uncertain.
Laurie L. Baggio +7 more
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Oxidized LDL upregulates macrophage DPP4 expression via TLR4/TRIF/CD36 pathwaysResearch in context
EBioMedicine, 2019 Background: We and others have shown that dipeptidyl peptidase-IV (DPP4) expression is increased in obesity/atherosclerosis and is positively correlated with atherosclerotic burden.
Xiaoquan Rao +9 more
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Frontiers in Pharmacology, 2022 Dipeptidyl peptidase 4 (DPP4) has been proposed as a marker for activated fibroblasts in fibrotic disease. We aimed to investigate whether a profibrotic DPP4 phenotype is present in lung tissue from patients with idiopathic pulmonary fibrosis (IPF).
Måns Kadefors +6 more
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Exploring structural dynamics of the MERS-CoV receptor DPP4 and mutant DPP4 receptors
Journal of Biomolecular Structure and Dynamics, 2020 Mouse DPP4 (mDPP4) receptor is not a functional receptor for MERS-CoV while human DPP4 (hDPP4) is, despite the high similarities between hDPP4 and mDPP4 receptors. The variability of DPP4 receptors against MERS-CoV is not fully investigated, especially conformational and structural differences. Therefore, investigating the conformational differences of
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Biomedicines, 2022 Dipeptidyl-peptidase-4 (DPP4) inhibitors are novel medicines for diabetes. The SAVOR-TIMI-53 clinical trial revealed increased heart-failure-associated hospitalization in saxagliptin-treated patients. Although this side effect could limit therapeutic use,
Imre Vörös +10 more
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The regulatory role of DPP4 in atherosclerotic disease
Cardiovascular Diabetology, 2017 The increasing prevalence of atherosclerosis has become a worldwide health concern. Although significant progress has been made in the understanding of atherosclerosis pathogenesis, the underlying mechanisms are not fully understood. Recent studies suggest dipeptidyl peptidase-4 (DPP4), a regulator of inflammation and metabolism, may be involved in the
Lihua Duan +4 more
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Chemoproteomic identification of a DPP4 homolog in Bacteroides thetaiotaomicron
Nature Chemical Biology, 2023 Serine hydrolases play important roles in signaling and human metabolism, yet little is known about their functions in gut commensal bacteria. Using bioinformatics and chemoproteomics, we identify serine hydrolases in the gut commensal Bacteroides thetaiotaomicron that are specific to the Bacteroidetes phylum.
Laura J. Keller +16 more
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Frontiers in Oncology, 2021 Metabolic reprogramming could promote cellular adaptation in response to chemotherapeutic drugs in cancer cells. Herein, we aimed to characterize the metabolomic profiles regulated by Dipeptidyl Peptidase 4 (DPP4) in methotrexate (MTX)-resistant ...
Weijie Yuan +4 more
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