Results 111 to 120 of about 261,882 (142)

Stable Gastric Pentadecapeptide BPC 157 and NO-System

2023
Stable gastric pentadecapeptide BPC 157 is known with very safe profile when used to be in ulcerative colitis and now multiple sclerosis trial, lethal dose (LD1) not achieved. Its pleiotropic beneficial effects were largely combined with its particular modulatory effect on NO-system functions, providing that BPC 157 may counteract adverse effect of ...
Sikirić, Predrag, Boban Blagaić, Alenka, Tvrdeić, Ante, Krezić, Ivan, Gojković, Slaven, Žižek, Helena, Sikirić, Sunčana, Štrbe, Sanja, Smoday, Ivan Maria, Lovrić, Eva, Škrtić, Anita, Seiwerth, Sven   +11 more
openaire   +2 more sources

Pentadecapeptide BPC 157 and the esophagocutaneous fistula healing therapy

European Journal of Pharmacology, 2013
Esophagocutaneous fistulas are a failure of the NO-system, due to NO-synthase blockage by the NOS-blocker L-NAME consequently counteracted by l-arginine and gastric pentadecapeptide BPC 157 (l-arginine
Cesarec, Vedran, Becejac, Tomislav, Misic, Marija, Djakovic, Zeljko, Olujic, Danijela, Drmic, Domagoj, Brcic, Luka, Rokotov, Dinko Stancic, Seiwerth, Sven, Sikiric, Predrag   +9 more
openaire   +2 more sources

Fistulas Healing. Stable Gastric Pentadecapeptide BPC 157 Therapy

Current Pharmaceutical Design, 2020
This review is focused on the healing of fistulas and stable gastric pentadecapeptide BPC 157. Assuming that the healing of the various wounds is essential also for the gastrointestinal fistulas healing, the healing effect on fistulas in rats, consistently noted with the stable gastric pentadecapeptide BPC 157, may raise several interesting ...
Robert Klicek, Ivan Krezić, Katarina Kašnik Kovač   +2 more
exaly   +3 more sources

Toxicity by NSAIDs. Counteraction by Stable Gastric Pentadecapeptide BPC 157

Current Pharmaceutical Design, 2012
Stable gastric pentadecapeptide BPC 157 is an anti-ulcer peptidergic agent, proven in clinical trials to be both safe in inflammatory bowel disease (PL-10, PLD-116, PL 14736) and wound healing, stable in human gastric juice, with no toxicity being reported. Recently, we claim that BPC 157 may be used as an antidote against NSAIDs. We focused on BPC 157
Sikirić, Predrag, Seiwerth, Sven, Ručman, Rudolf, Turković, Branko, Stančić-Rokotov, Dinko, Brčić, Luka, Sever, Marko, Kliček, Robert, Radić, Božo, Drmić, Domagoj, Ilić, Spomenko, Kolenc, Danijela, Aralica, Gorana, Safić, Hana, Šuran, Jelena, Rak, Davor, Džidić, Senka, Vrčić, Hrvoje, Sebečić, Božidar   +18 more
openaire   +3 more sources

Effects of BPC 157 on the healing of corneal lesions.

1997
The expariments suggest that BPC 157 and ranitidine have beneficial effect on the healing of corneal lesions.
Nasić, Mirjana, Ćurković, Tihomir, Seiwerth, Sven, Sikirić, Predrag, Štambuk, Nikola, Konjevoda, Paško   +5 more
openaire   +3 more sources

Gastric Pentadecapeptide BPC 157 and Short Bowel Syndrome in Rats

Digestive Diseases and Sciences, 2008
The gastric pentadecapeptide BPC 157, which was shown to be safe as an antiulcer peptide in trials for inflammatory bowel disease (PL14736, Pliva), successfully healed intestinal anastomosis and fistula in rat. Therefore, we studied for 4 weeks rats with escalating short bowel syndrome and progressive weight loss after small bowel resection from fourth
Sever, Marko, Kliček, Robert, Radić, Božo, Brčić, Luka, Zoričić, Ivan, Drmić, Domagoj, Ivica, Mihovil, Barišić, Ivan, Ilić, Spomenko, Berkopić, Lidija, Boban Blagaić, Alenka, Ćorić, Marijana, Kolenc, Danijela, Vrčić, Hrvoje, Anić, Tomislav, Seiwerth, Sven, Sikirić, Predrag   +16 more
openaire   +4 more sources

Focus on Ulcerative Colitis: Stable Gastric Pentadecapeptide BPC 157

Current Medicinal Chemistry, 2012
Stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, M.W. 1419) may be the new drug stable in human gastric juice, effective both in the upper and lower GI tract, and free of side effects. BPC 157, in addition to an antiulcer effect efficient in therapy of inflammatory bowel disease (IBD) (PL 14736) so far only tested in clinical phase II, has a ...
P, Sikiric, S, Seiwerth, R, Rucman, B, Turkovic, D S, Rokotov, L, Brcic, M, Sever, R, Klicek, B, Radic, D, Drmic, S, Ilic, D, Kolenc, V, Stambolija, Z, Zoricic, H, Vrcic, B, Sebecic   +15 more
openaire   +2 more sources

Peptide therapy with pentadecapeptide BPC 157 in traumatic nerve injury

Regulatory Peptides, 2010
We focused on the healing of rat transected sciatic nerve and improvement made by stable gastric pentadecapeptide BPC 157 (10 microg, 10ng/kg) applied shortly after injury (i) intraperitoneally/intragastrically/locally, at the site of anastomosis, or after (ii) non-anastomozed nerve tubing (7 mm nerve segment resected) directly into the tube ...
Gjurašin, Miroslav, Miklić, Pavle, Župančić, Božidar, Perović, Darko, Žarković, Kamelija, Brčić, Luka, Kolenc, Danijela, Radić, Božo, Seiwerth, Sven, Sikirić, Predrag   +9 more
openaire   +2 more sources

Antiinflammatory effect of BPC 157 on experimental periodontitis in rats.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2009
The pentadecapeptide BPC 157 has been shown to have anti-inflammatory and wound healing effects on multiple target tissues and organs. The purpose of the present study was to investigate the effect of BPC 157 on inflammation and bone resorption in experimental periodontitis in rats.
Kerémi, B., Lohinai, Z., Komora, P., Duhaj, S., Borsi, K., Jobbágy-óvári, G., Kálló, K., Székely, A.D., Fazekas, A., Dobó-Nagy, C., Sikirić, Predrag, Varga, G.   +11 more
openaire   +2 more sources

Traumatic brain injury in mice and pentadecapeptide BPC 157 effect

Regulatory Peptides, 2010
Gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, an anti-ulcer peptide, efficient in inflammatory bowel disease trials (PL 14736), no toxicity reported, improved muscle crush injury. After an induced traumatic brain injury (TBI) in mice by a falling weight, BPC 157 regimens (10.0microg, 10.0ng/kgi.p.) demonstrated a marked attenuation of damage with ...
Tudor, Mario, Jandrić, Ivan, Marović, Anton, Gjurašin, Miroslav, Perović, Darko, Radić, Božo, Boban Blagaić, Alenka, Kolenc, Danijela, Brčić, Luka, Žarković, Kamelija, Seiwerth, Sven, Sikirić, Predrag   +11 more
openaire   +3 more sources