Results 101 to 110 of about 830 (135)

BPC 157: The counteraction of succinylcholine, hyperkalemia, and arrhythmias

European Journal of Pharmacology, 2016
After the demonstration of its life-saving effect in severe hyperkalemia and the recovery of skeletal muscle after injury, pentadecapeptide BPC 157 has been shown to attenuate the local paralytic effect induced by succinylcholine, in addition to systemic muscle disability (and consequent muscle damage).
Sandra Uzun, Sven Seiwerth, Predrag Sikiric   +2 more
exaly   +4 more sources

Stable gastric pentadecapeptide BPC 157 and bupivacaine

European Journal of Pharmacology, 2016
Bupivacaine toxicity following accidental overdose still lacks therapeutic solution. However, there are major arguments for testing BPC 157 against bupivacaine toxicity in vivo in rats, in particular, and then finally, in vitro. These are: the lack of any known BPC 157 toxicity, a lifesaving effect via the mitigation of arrhythmias in rats underwent ...
Dean Strinic, Martina Lovric Bencic, Sandra Uzun   +2 more
exaly   +4 more sources

BPC 157's effect on healing

Journal of Physiology-Paris, 1997
The 15 amino acid agent BPC 157, showing a wide range of organoprotective action in different experimental models, was used in our experiments in order to establish its influence on different elements connected with the healing process. Elements thought to be of greatest importance in the process of healing are formation of granulation tissue ...
Seiwerth, Sven, Sikirić, Predrag, Grabarević, Željko, Zoričić, Ivan, Hanževački, Miro, Ljubanović, Danica, Ćorić, Vedran, Konjevoda, Paško, Petek, Marijan, Ručman, Rudolf, Turković, Branko, Perović, Darko, Mikuš, Darko, Jandrijević, Stipe, Medvidović, M., Tadić, Tamara, Romac, Branka, Kos, Josip, Perić, Josip, Kolega, Marko   +19 more
openaire   +4 more sources

BPC 157 and Blood Vessels

Current Pharmaceutical Design, 2014
This review focuses on the described effects of BPC 157 on blood vessels after different types of damage, and elucidate by investigating different aspects of vascular response to injury (endothelium damage, clotting, thrombosis, vasoconstriction, vasodilatation, vasculoneogenesis and edema formation) especially in connection to the healing processes ...
Seiwerth, Sven, Brčić, Luka, Batelja Vuletić, Lovorka, Kolenc, Danijela, Aralica, Gorana, Mišić, Marija, Zenko, Anita, Drmić, Domagoj, Rucman, Rudolf, Sikirić, Pradrag   +9 more
openaire   +2 more sources

Pentadecapeptide BPC 157 and the esophagocutaneous fistula healing therapy

European Journal of Pharmacology, 2013
Esophagocutaneous fistulas are a failure of the NO-system, due to NO-synthase blockage by the NOS-blocker L-NAME consequently counteracted by l-arginine and gastric pentadecapeptide BPC 157 (l-arginine
Domagoj Drmic, Sven Seiwerth, Predrag Sikiric   +2 more
exaly   +3 more sources

Fistulas Healing. Stable Gastric Pentadecapeptide BPC 157 Therapy

Current Pharmaceutical Design, 2020
This review is focused on the healing of fistulas and stable gastric pentadecapeptide BPC 157. Assuming that the healing of the various wounds is essential also for the gastrointestinal fistulas healing, the healing effect on fistulas in rats, consistently noted with the stable gastric pentadecapeptide BPC 157, may raise several interesting ...
Robert Klicek, Ivan Krezić, Katarina Kasnik Kovac   +2 more
exaly   +3 more sources

Stable Gastric Pentadecapeptide BPC 157-NO-system Relation

Current Pharmaceutical Design, 2014
We reviewed stable gastric pentadecapeptide BPC 157-NO-system-relation, its close participation in Moncada's (maintained vascular integrity, platelets control) homeostatic healing response of NO-system to injury. Namely, BPC 157's particular healing effect also affects all events after vascular integrity loss (dependent on circumstances, it reduces ...
Sikirić, Predrag, Seiwerth, Sven, Ručman, Rudolf, Turković, Branko, Stančić - Rokotov, Dinko, Brčić, Luka, Sever, Marko, Kliček, Robert, Radić, Božo, Drmić, Domagoj, Ilić, Spomenko, Kolenc, Danijela, Aralica, Gorana, Stupnišek, Marijana, Šuran, Jelena, Barišić, Ivan, Džidić, Senka, Vrčić, Hrvoje, Šebečić, Božidar   +18 more
openaire   +4 more sources

Stable Gastric Pentadecapeptide BPC 157 and NO-System

2023
Stable gastric pentadecapeptide BPC 157 is known with very safe profile when used to be in ulcerative colitis and now multiple sclerosis trial, lethal dose (LD1) not achieved. Its pleiotropic beneficial effects were largely combined with its particular modulatory effect on NO-system functions, providing that BPC 157 may counteract adverse effect of ...
Predrag Sikiric, Domagoj Drmic, Alenka Boban Blagaic, Ante Tvrdeic, Ivan Krezic, Slaven Gojkovic, Helena Zizek, Suncana Sikiric, Sanja Strbe, Ivan Marija Smoday, Eva Lovric, Anita Skrtic, Sven Seiwerth   +12 more
openaire   +2 more sources

Toxicity by NSAIDs. Counteraction by Stable Gastric Pentadecapeptide BPC 157

Current Pharmaceutical Design, 2012
Stable gastric pentadecapeptide BPC 157 is an anti-ulcer peptidergic agent, proven in clinical trials to be both safe in inflammatory bowel disease (PL-10, PLD-116, PL 14736) and wound healing, stable in human gastric juice, with no toxicity being reported. Recently, we claim that BPC 157 may be used as an antidote against NSAIDs. We focused on BPC 157
Sikirić, Predrag, Seiwerth, Sven, Ručman, Rudolf, Turković, Branko, Stančić-Rokotov, Dinko, Brčić, Luka, Sever, Marko, Kliček, Robert, Radić, Božo, Drmić, Domagoj, Ilić, Spomenko, Kolenc, Danijela, Aralica, Gorana, Safić, Hana, Šuran, Jelena, Rak, Davor, Džidić, Senka, Vrčić, Hrvoje, Sebečić, Božidar   +18 more
openaire   +2 more sources

Effects of BPC 157 on the healing of corneal lesions.

1997
The expariments suggest that BPC 157 and ranitidine have beneficial effect on the healing of corneal lesions.
Nasić, Mirjana, Ćurković, Tihomir, Seiwerth, Sven, Sikirić, Predrag, Štambuk, Nikola, Konjevoda, Paško   +5 more
openaire   +3 more sources