Results 1 to 10 of about 17,887 (202)
Mitochondria and Cytoprotection
Biochemistry Research International, 2012 no ...
Brenner, Catherine +2 more
openaire +5 more sources
Cell Stress & Chaperones, 2000 In vitro and ex vivo tissue models provide a useful level of biological organization for cytoprotection studies positioned between cultured cells and intact animals. We have used 2 such models, primary tissue cultures of winter flounder renal secretory epithelium and ex vivo preparations of rat intestinal tissues, the latter to access the ...
L E, Hightower +7 more
openaire +3 more sources
Liver cytoprotection by prostaglandins
Pharmacology & Therapeutics, 1993 During the last decade intensive work on the relationships between the liver and the arachidonic acid cascade has greatly expanded our knowledge of this area of research. The liver has emerged as the major organ participating in the degradation and elimination of arachidonate products of systemic origin.
Quiroga, Jorge, Prieto, Jesus
openaire +2 more sources
NRF2 signaling in cytoprotection and metabolism
British Journal of Pharmacology, 2023 The KEAP1-NRF2 system plays a central role in cytoprotection and defense mechanisms against oxidative stress. Because KEAP1 serves as a biosensor for electrophiles by using its reactive thiols and because NRF2 is a transcriptional factor regulating genes involved in the sulfur-mediated redox reactions, the KEAP1-NRF2 system has been regarded as a ...
Shohei Murakami +4 more
openaire +2 more sources
Cytoprotection by prostaglandins
Gastroenterology, 1979 Prostaglandins (PG) are a group of ZO-carbon oxy- genated fatty acids that are present in most mamma- lian cells and tissues. Approximately 20 of these chemicals have been identified in tissues and body fluids, whereas hundreds have been synthesized as analogs or derivatives of the natural PG.
openaire +3 more sources
A mechanism for prostaglandin cytoprotection
Journal of British Surgery, 1980 Abstract Topical 16,16-dimethyl (dm) prostaglandin E2 produces an alkaline secretion from the canine stomach. This study attempts to assess whether this prostaglandin-induced secretion might have a cytoprotective role. Chambered ex vivo perfused wedges of canine stomach were divided into equal halves: a control and test side.
J M, McGreevy, F G, Moody
openaire +2 more sources
Phloretin cytoprotection and toxicity
Chemico-Biological Interactions, 2018 Phloretin (Phl) is a dihydrochalcone flavonoid with significant cytoprotective properties; e.g., free radical trapping, electrophile scavenging. Based on this, it has been suggested that Phl might be useful in the treatment of pathogenic processes and prevention of drug toxicities.
Brian C. Geohagen +4 more
openaire +3 more sources
Gastrointestinal Cytoprotection by PPAR Ligands [PDF]
PPAR Research, 2010 Peroxisome proliferator-activated receptor (PPAR) is a nuclear receptor that is known to play a central role in lipid metabolism and insulin sensitivity as well as inflammation and cell proliferation. According to the results obtained from studies on several animal models of gastrointestinal inflammation, PPAR has been implicated in the regulation of ...
Yuji Naito +2 more
openaire +3 more sources
Cytoprotective roles for autophagy
Current Opinion in Cell Biology, 2010 Macroautophagy (referred to as autophagy in this review) is a genetically regulated bulk degradation program conserved from yeast to humans, in which cytoplasmic substrates, such as damaged organelles and long-lived proteins, are delivered to lysosomes for degradation.
Moreau, Kevin +2 more
openaire +2 more sources
Adenosine, Oxidative Stress and Cytoprotection
Japanese Journal of Pharmacology, 2001 Adenosine, a metabolite of ATP, serves a number of important physiological roles in the body. These actions contribute to sedation, bradycardia, vasorelaxation, inhibition of lipolysis and regulation of the immune system and are mediated, in part, through activation of three distinct adenosine receptor (AR) subtypes.
Ramkumar, Vickram +2 more
openaire +3 more sources