Results 31 to 40 of about 18,006 (203)
Selenium in Oncology: From Chemistry to Clinics
Molecules, 2009 The essential trace element selenium, which is a crucial cofactor in the most important endogenous antioxidative systems of the human body, is attracting more and more the attention of both laypersons and expert groups. The interest of oncologists mainly
Oliver Micke +4 more
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Cytoprotection by prostaglandins
Gastroenterology, 1979 Prostaglandins (PG) are a group of ZO-carbon oxy- genated fatty acids that are present in most mamma- lian cells and tissues. Approximately 20 of these chemicals have been identified in tissues and body fluids, whereas hundreds have been synthesized as analogs or derivatives of the natural PG.
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau +11 more
wiley +1 more source
NRF2 signaling in cytoprotection and metabolism
British Journal of Pharmacology, 2023 The KEAP1-NRF2 system plays a central role in cytoprotection and defense mechanisms against oxidative stress. Because KEAP1 serves as a biosensor for electrophiles by using its reactive thiols and because NRF2 is a transcriptional factor regulating genes involved in the sulfur-mediated redox reactions, the KEAP1-NRF2 system has been regarded as a ...
Shohei Murakami +4 more
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Advanced Science, EarlyView.This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan +17 more
wiley +1 more source
Role of the Sterol Regulatory Element Binding Protein Pathway in Tumorigenesis
Frontiers in Oncology, 2020 Metabolic changes are a major feature of tumors, including various metabolic forms, such as energy, lipid, and amino acid metabolism. Sterol regulatory element binding proteins (SREBPs) are important modules in regulating lipid metabolism and play an ...
Tao Jiang, Guangji Zhang, Zhaohuan Lou
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Advanced Science, EarlyView.HLP‐SeNPs, a Lysimachia christinae polysaccharide‐modified selenium nanoparticle, treat kidney stones by downregulating TOMM22 expression, which reduces PINK1 translocation into mitochondria and promotes its retention on the outer mitochondrial membrane.
Junyi Yang +10 more
wiley +1 more source
Marine Drugs, 2017 Sargassum muticum is a brown seaweed with strong potential to be used as a functional food ingredient, mainly due to its antioxidant properties. It is widely used in traditional oriental medicine for the treatment of numerous diseases.
Susete Pinteus +7 more
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A mechanism for prostaglandin cytoprotection
Journal of British Surgery, 1980 Abstract Topical 16,16-dimethyl (dm) prostaglandin E2 produces an alkaline secretion from the canine stomach. This study attempts to assess whether this prostaglandin-induced secretion might have a cytoprotective role. Chambered ex vivo perfused wedges of canine stomach were divided into equal halves: a control and test side.
J M, McGreevy, F G, Moody
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Advanced Science, EarlyView.CeO2‐x/Pt single‐atom nano‐island is constructed via low‐temperature reduction, featuring abundant oxygen vacancies and an island–sea structure. It delivers outstanding multi‐enzyme‐mimetic activity and ROS‐scavenging efficiency. Density functional theory reveals optimized electronic structures and reaction pathways.
Yang Zhu +12 more
wiley +1 more source