Results 31 to 40 of about 31,874 (246)
A Randomized, Double-Blinded, Phase II Trial of Gemcitabine and Nab-Paclitaxel Plus Apatorsen or Placebo in Patients with Metastatic Pancreatic Cancer: The RAINIER Trial. [PDF]
, 2017 Lessons learnedThe addition of the heat shock protein 27 (Hsp27)-targeting antisense oligonucleotide, apatorsen, to a standard first-line chemotherapy regimen did not result in improved survival in unselected patients with metastatic pancreatic cancer ...
Al-Hazzouri, Ahmed +14 more
core +1 more source
Medisan, 2022 Introduction: The oxidative stress can affect the biological membranes of different cellular types in the organism, which has been evidenced in the damages to the tissues and organs of patients with COVID-19, reason why the recent investigations are ...
Yoandra Mora Tassé +3 more
doaj
Morphological Characteristics of the Lung during Lipopolysaccharide and Perfluorane Inhalation
Общая реаниматология, 2015 The use of perfluorane for the cytoprotection of lung structures in gram-negative lung infections has been inadequately studied. Objective: to experimentally reveal the pattern of morphological changes in the lung during combined inhalation of ...
A. M. Golubev +3 more
doaj +1 more source
NRF2 regulates HER1 signaling pathway to modulate the sensitivity of ovarian cancer cells to lapatinib and erlotinib [PDF]
, 2017 NF-E2-related factor 2 (NRF2) regulates the transcription of a battery of metabolic and cytoprotective genes. NRF2 and epidermal growth factor receptors (EGFRs/HERs) are regulators of cellular proliferation and determinants of cancer initiation and ...
Bown, James L. +5 more
core +6 more sources
Вестник анестезиологии и реаниматологии, 2017 The changes of the intracellular potentials by the action of sevoflurane were studied for the diagnostic intact neurons of the isolated cerebrospinal axis of the Planorbarius corneus using intracellular electrodes.
A. I. Vislobokov +3 more
doaj +1 more source
Antioxidants, 2019 The proliferation and motile activity of prostate epithelial (Pnt2) and cancer cells (DU-145; PC-3) in the presence of bioavailable compounds from green coffee beans (GCB), wholemeal wheat bread (WMWB), and its GCB-fortified variant were analyzed.
Urszula Gawlik-Dziki +6 more
doaj +1 more source
Antioxidants, 2022 Dimethyl fumarate (DMF) is a well-known activator of Nrf2 (NF-E2-related factor 2), used in the treatment of psoriasis and multiple sclerosis. The mechanism of action consists in the modification of the cysteine residues on the Nrf2-inhibitor Keap1, thus
Federico Manai, Marialaura Amadio
doaj +1 more source
Flavonoids and Mitochondria: Activation of Cytoprotective Pathways?
Molecules, 2020 A large number of diverse mechanisms that lead to cytoprotection have been described to date. Perhaps, not surprisingly, the role of mitochondria in these phenomena is notable. In addition to being metabolic centers, due to their role in cell catabolism,
Anna Kicinska, Wieslawa Jarmuszkiewicz
doaj +1 more source
Features of therapeutic correction of GERD: focus on cytoprotection (with a clinical case)
Медицинский совет, 2022 Тo date, the possible links of the pathogenesis of this disease have been well studied and described, which predetermine certain approaches to the treatment of various variants of gastroesophageal reflux disease (GERD).
I. G. Pakhomova
doaj +1 more source
Estrogen Protects the Female Heart from Ischemia/Reperfusion Injury through Manganese Superoxide Dismutase Phosphorylation by Mitochondrial p38β at Threonine 79 and Serine 106. [PDF]
, 2016 A collective body of evidence indicates that estrogen protects the heart from myocardial ischemia/reperfusion (I/R) injury, but the underlying mechanism remains incompletely understood. We have previously delineated a novel mechanism of how 17β-estradiol
Kim, Jin Kyung, Liu, Han, Luo, Tao
core +1 more source