Results 51 to 60 of about 22,691 (239)
Cytoprotection by prostaglandins
Gastroenterology, 1979 Prostaglandins (PG) are a group of ZO-carbon oxy- genated fatty acids that are present in most mamma- lian cells and tissues. Approximately 20 of these chemicals have been identified in tissues and body fluids, whereas hundreds have been synthesized as analogs or derivatives of the natural PG.
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Role of the Sterol Regulatory Element Binding Protein Pathway in Tumorigenesis
Frontiers in Oncology, 2020 Metabolic changes are a major feature of tumors, including various metabolic forms, such as energy, lipid, and amino acid metabolism. Sterol regulatory element binding proteins (SREBPs) are important modules in regulating lipid metabolism and play an ...
Tao Jiang, Guangji Zhang, Zhaohuan Lou
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Advanced Science, EarlyView.A thermo‐responsive rectal delivery platform integrating probiotic‐derived extracellular vesicles within a hyaluronic acid‐based copolymer enables localized and sustained therapy for ulcerative colitis. The formulation effectively suppresses inflammation, promotes macrophage polarization toward a regenerative phenotype, restores epithelial barrier ...
Ayushi Mairal +5 more
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Adaptive cytoprotection in the small intestine: role of mucus
, 1993 Gastric mucosal injury induced by strong irritants can be dramatically reduced by pretreating the mucosa with mild forms of the same irritant. This phenomenon has been termed "adaptive cytoprotection." The aim of the present study was to use in vivo and
G. Cepinskas +2 more
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A mechanism for prostaglandin cytoprotection
Journal of British Surgery, 1980 Abstract Topical 16,16-dimethyl (dm) prostaglandin E2 produces an alkaline secretion from the canine stomach. This study attempts to assess whether this prostaglandin-induced secretion might have a cytoprotective role. Chambered ex vivo perfused wedges of canine stomach were divided into equal halves: a control and test side.
J M, McGreevy, F G, Moody
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Marine Drugs, 2017 Sargassum muticum is a brown seaweed with strong potential to be used as a functional food ingredient, mainly due to its antioxidant properties. It is widely used in traditional oriental medicine for the treatment of numerous diseases.
Susete Pinteus +7 more
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Advanced Science, EarlyView.Through AI‐assisted screening from FDA‐approved API to overcome the limitations of bacterial osteomyelitis treatment, glycyrrhizic acid and simvastatin are identified as a multifunctional combination capable of self‐assembling into mechanism‐targeting nanocrystals that effectively neutralize reactive oxygen species, suppress M1 macrophage polarization,
Yu Han +11 more
wiley +1 more source
Advanced Science, EarlyView.CFP/PC@MnO2 hydrogel integrates ROS scavenging, oxygen delivery, oxidative stress reduction, immunomodulation, and photothermal antibacterial properties. The incorporation of PC@MnO2 NPs endows the hydrogel with multiple functional advantages tailored to the pathological microenvironment of diabetic wounds, including efficient ROS clearance, mitigation
Zhi Xu +9 more
wiley +1 more source
Cytoprotective roles for autophagy
Current Opinion in Cell Biology, 2010 Macroautophagy (referred to as autophagy in this review) is a genetically regulated bulk degradation program conserved from yeast to humans, in which cytoplasmic substrates, such as damaged organelles and long-lived proteins, are delivered to lysosomes for degradation.
Moreau, Kevin +2 more
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Gastrointestinal Cytoprotection by PPAR Ligands [PDF]
PPAR Research, 2010 Peroxisome proliferator-activated receptor (PPAR) is a nuclear receptor that is known to play a central role in lipid metabolism and insulin sensitivity as well as inflammation and cell proliferation. According to the results obtained from studies on several animal models of gastrointestinal inflammation, PPAR has been implicated in the regulation of ...
Yuji Naito +2 more
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