Results 51 to 60 of about 31,874 (246)

Role of the Sterol Regulatory Element Binding Protein Pathway in Tumorigenesis

Frontiers in Oncology, 2020
Metabolic changes are a major feature of tumors, including various metabolic forms, such as energy, lipid, and amino acid metabolism. Sterol regulatory element binding proteins (SREBPs) are important modules in regulating lipid metabolism and play an ...
Tao Jiang, Guangji Zhang, Zhaohuan Lou
doaj   +1 more source

Quantitative analysis of NRF2 pathway reveals key elements of the regulatory circuits underlying antioxidant response and proliferation of ovarian cancer cells [PDF]

, 2014
Cells are constantly exposed to Reactive Oxygen Species (ROS) produced both endogenously to meet physiological requirements and from exogenous sources.
Bown, James, Deeni, Yusuf, Goltsov, Alexey, Harrison, David J., Khalil, Hilal S., Langdon, Simon P.   +5 more
core   +4 more sources

QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study

Advanced Science, EarlyView.
The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda, Ada Bernaus Vives, Michał Wojciechowski, Dinh Quoc Huy Pham, Mateusz Chwastyk, Mario Vallejo, Anna Novials, Douglas V. Laurents, Mariano Carrión‐Vázquez   +8 more
wiley   +1 more source

An Insight into Sargassum muticum Cytoprotective Mechanisms against Oxidative Stress on a Human Cell In Vitro Model

Marine Drugs, 2017
Sargassum muticum is a brown seaweed with strong potential to be used as a functional food ingredient, mainly due to its antioxidant properties. It is widely used in traditional oriental medicine for the treatment of numerous diseases.
Susete Pinteus, Marco F. L. Lemos, Joana Silva, Celso Alves, Agnieszka Neugebauer, Rafaela Freitas, Adriana Duarte, Rui Pedrosa   +7 more
doaj   +1 more source

Cytoprotection by prostaglandins

Gastroenterology, 1979
Prostaglandins (PG) are a group of ZO-carbon oxy- genated fatty acids that are present in most mamma- lian cells and tissues. Approximately 20 of these chemicals have been identified in tissues and body fluids, whereas hundreds have been synthesized as analogs or derivatives of the natural PG.
openaire   +3 more sources

PACAP neuropeptide promotes Hepatocellular Protection via CREB-KLF4 dependent autophagy in mouse liver Ischemia Reperfusion Injury. [PDF]

, 2020
Organ ischemia reperfusion injury (IRI), associated with acute hepatocyte death, remains an unresolved problem in clinical orthotopic liver transplantation (OLT).
Busuttil, Ronald W, Gao, Feng, Ji, Haofeng, Kupiec-Weglinski, Jerzy W, Liu, Yuanxing, Shen, Xiu-da, Xue, Zhengze, Zhang, Cheng, Zhang, Yu, Zheng, Shusen   +9 more
core  

The cardiomyocyte "redox rheostat": Redox signalling via the AMPK-mTOR axis and regulation of gene and protein expression balancing survival and death. [PDF]

, 2019
Reactive oxygen species (ROS) play a key role in development of heart failure but, at a cellular level, their effects range from cytoprotection to induction of cell death.
Clerk, A, Handa, BS, Lay, K, Markou, T, Meijles, DN, Patel, R, Rostron, KA, Sugden, PH, Wong, B, Zoumpoulidou, G   +9 more
core   +3 more sources

Neutrophil‐Driven Cascade‐Targeted Nanocarriers Restore Mitochondrial Homeostasis to Ameliorate Renal Ischemia–Reperfusion Injury

Advanced Science, EarlyView.
A neutrophil‐mediated dual‐targeting liposome (NKN‐LNP) is developed to treat renal ischemia–reperfusion injury. The system enables spatiotemporally controlled delivery of NMN to injured tubules via MMP‐2/9 activation and KIM1 recognition, restoring mitochondrial function through NAD+‐SIRT3 signaling and preventing the transition from acute kidney ...
Hangbin Ma, Yang Li, Shen Lin, Feifan Chu, Gaozhan Ren, Yinhui Mao, Mingzhi Wu, Yuning Ma, Qiwei Ji, Zujie Chen, Jinzhong Ji, Mingxin Sun, Yongpeng Xu, Xiaoli Sun, Longguang Tang, Hao Zhou   +15 more
wiley   +1 more source

Mitochondrial Enzymes Mimetic Ultrasmall Palladium Nanozymes Prevent Senescence and Neurodegeneration Through Metabolic Reprogramming

Advanced Science, EarlyView.
Simply constructed polyvinylpyrrolidone (PVP) modified palladium nanoparticles (PdP NPs) as cytochrome c oxidase (CcO) and superoxide dismutase (SOD) mimic are promising multifunctional nanoreactors to boost mitochondrial respiration chain function and refine homeostasis via regulation of mitochondrial dynamics and proteostasis sensor UPRmt, which ...
Wenshu Cong, Haiming Jing, Zinan Li, Wenjing Zhang, Nan Zhang, Yingqiu Xie, Shan Gao, Yuanyu Huang, Junyu Ning   +8 more
wiley   +1 more source

Crosstalk between NRF2 and HIPK2 shapes cytoprotective responses [PDF]

, 2017
Homeodomain interacting protein kinase-2 (HIPK2) is a member of the HIPK family of stress-responsive kinases that modulates cell growth, apoptosis, proliferation and development.
A Garufi, A Jain, A Singh, A T Dinkova-Kostova, AI Rojo, BN Chorley, C Giachino, C Lobry, C Rinaldo, C Sanchez, D Malhotra, DW Choi, E Gresko, EJ Ann, F Faul, F Radtke, G D'Orazi, G Wei, GM DeNicola, GP Dotto, H Deshmukh, H Koseki, H Sasaki, H Satoh, HJ Prochaska, HJ Schulten, I Dauth, IM Munoz, J D Hayes, J Pi, J Sjolund, JD Hayes, K Hailemariam, K Imberg-Kazdan, K Isono, K Isono, K Itoh, K Itoh, K Itoh, L de la Vega, L de la Vega, L de la Vega, L de la Vega, L Torrente, LM Solis, M McMahon, M Winter, MA Al-Beiti, MA Calzado, MJ Canet, MO Kelleher, MS Lawrence, OH Lee, P Cabello, P Rada, QK Li, R Moreno, R Puca, S Berber, S Chowdhry, S Dayalan Naidu, S Giraud, S Homma, S Iacovelli, S Kalra, T Honda, T Honda, T Nguyen, T Ohta, T Shibata, T Shibata, TG Hofmann, TG Hofmann, V Lapin, VP Kelly, VV Saul, W Du, Y Aikawa, Y Akaike, Y Jin, Y Kawamoto, Y Mitsuishi, Y Shang, YR Kim, ZA Kemmerer   +84 more
core   +2 more sources